Posted by admin on Oct 31, 2019 in |
Diabetes mellitus is a lasting metabolic disability regarding enhance etiology and permanent degenerating complications. Sexual abnormalities (Hypogonadism, infertility, etc.) are outfit a two of the discombobulate ingenious stringency of diabetes mellitus. Different hypoglycemic agents are used to control diabetes mellitus, but very few formulations are available to treat secondary complications. Results of the present study establish the anti-diabetic properties of Camellia sinensis and its impact on the male reproductive systems of the streptozotocin-induced diabetic male...
Read More
Posted by admin on Oct 31, 2019 in |
Quality by Design (QbD) has become an important concept for the pharmaceutical industry, and ICH recommends this concept through the Guideline Q8 (R2) wherein if the method is proved to be rugged and robust within the limits of a Design Space then approval may be requested for such a Design Space, and the method does not need redevelopment, revalidation, and reapproval during transfers, thereby saving significant time and resources. In this study, the QbD approach was used to develop a reverse-phase–high-performance liquid chromatography (RP–HPLC) method that could be applied for the estimation of several antibacterial agents of the fluoroquinolone group. The method was applied to five selected fluoroquinolones, namely, ciprofloxacin, levofloxacin, norfloxacin, moxifloxacin, and ofloxacin. The method developed used C18 column of make Phenomenex (250 mm × 4.6 mm, 5 μm) with mobile phase comprising of methanol and phosphate buffer (pH 3.0) in the proportion 70:30 at a flow rate of 1.25 ml/min and detection was carried out using a PDA detector at 294 nm. The method while being...
Read More
Posted by admin on Oct 31, 2019 in |
A novel coordination complex of 2-aminobenzonitrile (ABN) and octanoate ion (OC) with Cu(II) metal ion has been prepared by using microwave irradiation. The molecular formula and the geometry of the complex have been deduced from elemental analysis, molar conductance, magnetic moment, electronic spectra, FT- IR spectra, cyclic voltammetry, thermal analysis and EPR spectra. The molar conductance value indicates that the complex is non-electrolyte (1:0) type. The electronic spectrum and the magnetic moment indicate the geometry of the complex is octahedral. FT-IR spectra show that 2-aminobenzonitrile is coordinated to the metal ion in a bidentate and octanoate ion in a monodentate manner. The metal-ligand covalency of Cu(II) complex has been arrived at from EPR spectrum. The antimicrobial activities of ligands and their Cu(II) complex were studied against the microorganisms, viz., staphylococcus aureus, streptococcus, Klebsiella, pseudomonas aeruginosa, salmonella typhi, Enterobacter, E. coli, C. albicans, Aspergillus flavus and Aspergillus niger by agar – well diffusion method. The complex shows potential activity against the bacteria and fungi as compared to the free ligands....
Read More
Posted by admin on Oct 31, 2019 in |
The powder date palm cake is sold in coffee and confectionary shops in the central region of the Kingdom of Saudi Arabia, where it is used as a hot drink in the form of decoction. It is alleged by users in the local community in Saudi Arabia to improve fertility. The date palm cake is the roasted grounded seeds of the date palm (Phoenix dactylifera L.). The objective of this study is to evaluate the potential protective effect of the date palm extracts against nickel chloride-induced infertility in male mice. The effects of nickel compounds on reproduction in rodent models are well documented. The method adopted is the injection of nickel chloride (10 mg/kg) intra-peritoneal to induce infertility in male mice. The chloroform and ethyl acetate extracts were used to assess their protective effects. Sperm abnormalities and testicular histopathology were evaluated. The results showed that the administration of chloroform extract enhanced the sperm count and reduced sperm abnormalities. Moreover, the abnormalities induced by nickel chloride were restored to a...
Read More
Posted by admin on Sep 30, 2019 in |
The leading factor restraining the intensification of herd reproduction is endometritis. The article states that the microflora of cow uterine exudate in chronic purulent-catarrhal endometritis is represented by Staphylococcus aureus, Escherichia coli, Proteus vulgaris, Citrobacter freundii, Streptococcus faecalis, Streptococcus faecium, as well as anaerobes and group С Streptococci. The drug “Mitreс” showed the greatest effectiveness of suppressing the growth of the majority of isolated strains of microorganisms. Its zone of growth inhibition was as follows: Streptococcus faecium – 31 ± 2.06 mm, Citrobacter freundii – 30 ± 0.00 mm, anaerobes – 29 ± 0.00 mm, Proteus vulgaris – 28.5 ± 1.72 mm, Escherichia coli – 27.0 ± 1.45 mm; group C Streptococci– 27.32 ± 2.12 mm; Staphylococcus aureus strains- 25.5 ± 1.66 mm; Streptococcus faecalis– 25.0 ± 1.12 mm. The recovery of cows with chronic purulent-catarrhal endometritis after applying “Tilozinocarum” was 80%, “Endometramag-T” showed 90%, and mitrec demonstrated 100% recovery. During the 90 days of observation of the experimental group of cows injected with the drug “Sepranol” fertilization occurred...
Read More
