Posted by admin on Sep 30, 2019 in |
Present work is aimed at development and characterization of phytosomes, novel drug delivery dosage form used to improve the bioavailability of the drug, containing ethanolic, aqueous, dichloromethane and ethyl acetate extract of Citrullus colocynthis to meet the need for better effectiveness and safety. Required phytosomal formulations were developed using different extracts of Citrullus colocynthis and phytosomes formed from the lecithin and cholesterol, then characterized. Characterization involved various parameters, such as Particle size determination, apparent solubility, entrapment efficiency, Scanning Electron Microscope, Fourier-Transform Infrared Spectroscopy, X-ray Diffraction (XRD), and dissolution study (in-vitro drug release). Particle size varied from 250 nm to 0.1 µm depending on the extract. The mean particle size of phytosomal complex of DCM extract of CC was scattered in a narrow range of 254 ± 20.0 nm, and polydispersity index was 0.857 ± 0.055, where phytosomal formulation of DCM extract shows better entrapment then other phytosomal formulation. Photomicrographs revealed that phytosomes were spherical in shape and uniform in...
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Posted by admin on Sep 30, 2019 in |
Metabolic syndrome is a group of several clinical conditions which is related to the prevalence of another disease such as cardiovascular disease, diabetes mellitus (DM) or increased fasting blood glucose level, visceral obesity, hypertension, etc. The major factor that affects the metabolic syndrome occurrence is diet composition.This research aimed to determine the influence of diet composition on metabolic syndrome prevalence. This study was performed using in-vivo method. The animal was divided into three groups, each administered a different composition of diet, which was high carbohydrate, high lipid, and high protein diet for 42 days. The parameters were body weight, HDL and triglyceride level, blood glucose level, and blood pressure. The results showed that each diet composition affected the glucose, HDL, triglyceride, and blood pressure level differently. The high-fat diet gave the most significant effect in HDL reducing and blood pressure elevation, while the high carbohydrate diet gave the most significant effect in blood glucose and triglyceride level elevation. It could be concluded that the lowest affecting food to metabolic...
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Posted by admin on Sep 30, 2019 in |
Cyclic imides such as succinimides, maleimides, phthalimide and their derivatives contain an imide ring and a general structure –CO-N(R)-CO- that confers hydrophobicity and neutral nature. Succinimide (pyrolidine 2,5-dione) is a synthetically versatile substrate used for the synthesis of heterocyclic compounds and as a raw material for drug synthesis. Derivatives of succinimide are of important biological and pharmaceutical uses such as antibacterial, antifungal, anticonvulsant, antitumor and antinociceptive. In spite of these activities, much of their action mechanisms at molecular and cellular levels remain to be elucidated. A new series of nickel(II) and copper(II) complexes of a new mannichbase1-((2,5-dioxopyrrolidin-1-yl)(4-methoxyphenyl) methyl) thiourea (LIGAND) have been synthesized. The structures of newly synthesized compounds have been explicated on the basis of elemental analysis, molar conductance, IR, UV-Visible, NMR, Mass, and Magnetic measurements. The binding of the copper sulfate complex of the ligand with calf thymus DNA has been investigated using absorption spectroscopy, fluorescence spectroscopy, and viscosity...
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Posted by admin on Sep 30, 2019 in |
Aim of the present study was to evaluate the antianxiety and antidepressant activity of Valeriana pyrolaefolia, a member of family Valerianaceae. The antianxiety and antidepressant activities of dichloromethane extract were evaluated using the elevated plus-maze model and porsolt’s despair swim test. The studies were conducted on lacca mice, and the test materials were administered per oral route. The dichloromethane extract of V. pyrolaefolia roots exhibited significant dose-dependent antianxiety activity at 400 mg/kg. The results were comparable to the standard diazepam (2 mg/kg). The extract also exhibited significant antidepressant activity at 400 mg/kg dose. The results were comparable to the standard imipramine (10 mg/kg). The TLC fingerprint profile of the bioactive extract was developed using precoated TLC plates of 0.2 mm thickness. Valtrate was used as a bioactive marker for developing TLC fingerprint profile. The solvent system comprising dichloromethane: ethyl methyl ketone (8: 2) was used for developing the TLC profile. The TL chromatogram showed valtrate as a major component of the...
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Posted by admin on Sep 30, 2019 in |
Metallic toxicity associated with Ayurvedic formulations like herbomineral preparation (Bhasma), especially because of heavy metals such as lead, has always been a matter of debate in the scientific community. Instead of that, ancient Ayurvedic literature reveals that sodhana process used for the preparation of such formulations, either decreases or eliminate the toxic effect of such heavy metals up to a negligible extent. But, the method for their standardization should be well defined. In present work, marketed lead preparation (Bhasma), In-house prepared lead preparation, and their corresponding micro/nano-particle have been evaluated for their physiochemical properties and toxicological impact. For the toxicity studies, instead of animals, two different methods like enzymatic inhibition and change in the growth pattern of yeast cells were explored to find out and establish the toxicity of such preparations. The results of the study reveal that sodhana process significantly effects to the physicochemical character of the metallic preparation and presence of heavy metals like lead effects to the activity of enzymes and growth pattern of the yeast...
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