Posted by admin on Dec 31, 2025 in |
The growing emphasis on sustainable agriculture has intensified interest in organic inputs such as Jeevamrutham, a traditional fermented formulation derived from cow dung, cow urine, jaggery, pulse flour, and soil. This study aimed to assess the effect of Jeevamrutham on the cultivation of Basella rubra L., a nutrient-rich leafy vegetable of the Basellaceae family. Field experiments were conducted to evaluate changes in soil nutrient status, irrigation water quality, physiological parameters, photosynthetic pigments, and biochemical constituents. Post-treatment soil analysis indicated notable increases in available nitrogen and phosphorus, while potassium showed moderate improvement. In contrast, certain micronutrients zinc, iron, manganese, copper and boron exhibited a slight decline, suggesting selective nutrient utilization. Water quality parameters, including pH, electrical conductivity, and dissolved salts, remained within acceptable limits for agricultural use, indicating no adverse environmental impact. Morphological observations revealed improved vine length, leaf number, and leaf area in treated plants. Biochemical assays demonstrated significant enhancement in chlorophyll a, chlorophyll b, total carotenoids, carbohydrate content, and protein levels, indicating improved photosynthetic efficiency and nutritional quality....
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Posted by admin on Dec 31, 2025 in |
A novel, robust, and sensitive high-performance liquid chromatography (HPLC) method was successfully developed and validated for the quantitative determination of (S)-(-)-amlodipine-o, o-di-p-toluoyl-D-tartrate, a crucial chiral intermediate in pharmaceutical synthesis. The analysis was carried out on a reversed-phase C18 column using a mobile phase comprising acetonitrile and phosphate buffer (pH 3.0) in a 60:40 (v/v) ratio, delivered at a flow rate of 1.0 mL/min. Detection was performed at 237 nm using a UV detector. Method validation followed ICH Q2(R1) guidelines and confirmed the approach’s linearity, accuracy, precision, specificity, robustness, and sensitivity. The method exhibited excellent linearity within the concentration range of 0.5–100 µg/mL, with a correlation coefficient (R2) of 0.9998. The limit of detection (LOD) and limit of quantification (LOQ) were found to be 0.15 µg/mL and 0.45 µg/mL, respectively. Precision results showed a relative standard deviation (RSD) of less than 1.5%, and recovery values ranged between 98.5% and 101.2%, indicating high accuracy. This validated HPLC method is well-suited for routine quality control and stability testing of (S)-(-)-amlodipine-o, o-di-p-toluoyl-D-tartrate in...
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Posted by admin on Dec 31, 2025 in |
Introduction: The elderly population has been defined as people who are older than 60 years. Essential Hypertension and Type 2 diabetes mellitus are rapidly emerging as public health problems among the geriatric population. WHO Core Drug Prescribing Indicators are used to measure Drug Utilization Patterns because it serve as the foundation for implementing changes to drug dispensing policies at the local and national levels. Irrational drug use can lead to adverse outcomes such as a decline in medication adherence, and the risk of drug-drug interactions, all of which can invariably lead to an increased risk of hospitalization, fatality rate, and healthcare costs. Objectives: To study the drug utilization patterns in Geriatric patients having Hypertension and Type 2 Diabetes Mellitus using WHO core drug prescribing indicators. Methods: This is an Observational, Cross-sectional study, data was collected in the Case record form from Medicine OPD. Geriatric Patients with HTN, Type-2DM both HTN and Type 2 DM were included in the study. This study found out Drug prescribing patterns using WHO core...
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Posted by admin on Dec 31, 2025 in |
Freshwater fish scales are an abundant and versatile source of high-quality gelatin, with benefits including improved thermal stability, reduced risk of endotoxic shock and zoonotic disease transmission. This work outlines characteristics of gelatin extracted from fish scale and its applicability in 3D bioprinting. The extracted gelatin has molecular weight ranging from 250-280 kDa and is >99% pure, with total impurity content <20ppm. A high bloom strength of 250g was obtained, demonstrating higher gelling ability under external stimuli. Proximate study shows encouraging biological characteristics; it is non-cytotoxic and devoid of any possible microorganisms, suggesting that it is suitable for biological applications. The gelatin also demonstrated cell viability of 146%, suggesting a favourable effect on cell growth. In-vivo studies showed no skin irritation or abnormal reactions after 72h of observation, confirming its potential use for biocompatible scaffold. Further, the study focused on optimizing synthesis of cross-linked gelatin to create an ink suitable for 3D bioprinting. Critical analysis was done on the optimized concentration range (5-20%) for the creation of ink as...
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Posted by admin on Dec 31, 2025 in |
Background: Female infertility is a substantial but sometimes disregarded factor in infertility in couples. The problem is made more difficult to resolve by social shame, cultural hurdles, and a dearth of thorough data on female infertility. Aims and Objectives: This study aimed to evaluate the current clinical practices, diagnostic approaches, and management strategies for female infertility among gynaecologists in India. Materials and Methods: A comprehensive survey was conducted during the 19th Annual Conference of the Indian Fertility Society (IFS), FERTIVISION-2023. A total of 1039 gynaecologists from various regions of India participated. The survey comprised 11 key questions on various aspects such as the percentage of female patients, common age, most common causes of infertility, prevalence of tubal factors, preferred ovulation induction drug in intrauterine insemination (IUI) cycles, the prevalence of polycystic ovarian syndrome (PCOS), and the preferred methods of ovulation tracking. Results: Amongst the participants, 38.80% (n=435) reported that 11-15% of their female patients faced fertility-related issues, the majority of women (39.3%) were in the 25–29 year age group....
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