Posted by admin on Oct 31, 2025 in |
Background: Poor management of biomedical waste (BMW) poses severe health and environmental risks, especially during the COVID-19 pandemic that saw an excess of infectious waste. The Biomedical Waste Management Rules of 2016, subsequently amended in 2018, provide guidelines for safe disposal; however, there remain considerable gaps in knowledge among healthcare personnel. The present research assessed and improved their knowledge, attitude, and practice (KAP) about COVID-19-related BMW via a structured teaching program (STP) at a tertiary care hospital in Northern India. Methodology: The quasi-experimental one-group pre-test post-test design was utilized in 50 health workers. Pre- and post-intervention KAP scores were quantitatively measured, correlations be-tween demographic parameters such as age, education, and clinical experience were compared. Findings: A majority of the participants were aged 25–34, 56% of them had a master’s degree, and 14% had 6–10 years of experience. Pre-intervention scores were as follows: knowledge – 70.83%, attitude – 80.83%, practice – 67.08%. Post-intervention, the knowledge increased to 78.83%, the attitude improved to 84.16%, and practice decreased slightly to 65%. There...
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Posted by admin on Oct 31, 2025 in |
This study investigates the imaging characteristics of testicular tumors through the use of Doppler sonography, emphasizing its significance as a first-line, non-invasive diagnostic modality for the evaluation of testicular masses. Testicular tumors represent a significant clinical concern due to their potential malignancy and impact on male reproductive health. High-resolution ultrasonography combined with color and spectral Doppler imaging, offers comprehensive insights into both the morphological structure and vascularity of testicular lesions. This dual approach enhances the clinician’s ability to distinguish between benign and malignant pathologies. The study presents a detailed analysis of seven clinically suspected cases of testicular tumors, encompassing a range of histopathological types such as lymphoma, sex cord-stromal tumors, and various non-seminomatous germ cell tumors (including yolk sac tumors, embryonal carcinomas, teratomas, and mixed germ cell tumors), as well as seminomas. Sonographic features observed in malignant tumors include heterogeneous echotexture, increased internal vascularity, and the presence of retroperitoneal lymphadenopathy, which are key indicators of aggressive disease. The findings demonstrate that Doppler ultrasound is not only effective in the...
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Posted by admin on Oct 31, 2025 in |
In this study, a series of novel N-(2,4′-dioxospiro[indoline-3,2′-thiazolidin]-3′-yl) isonicotinamide derivatives (VIa-l) were synthesized by cyclizing N1- (2-mercaptoacetyl) isonicotinohydrazide with various 5,6,7-substituted isatins. Structural confirmation of the new compounds was achieved using IR, Mass, H1, and C13 NMR spectroscopy techniques. In-silico molecular docking studies were conducted to identify the binding affinity of the synthesized compounds to the COX-2 enzyme (PDB ID: 3LN1), using PyRx software. The compounds were evaluated for in-vitro and in-vivo anti-inflammatory and antioxidant activities. For the in-vitro anti-inflammatory study, Cayman’s COX (ovine) colorimetric inhibitor screening assay kit was utilized, while for the in-vivo anti-inflammatory activity, the carrageenan-induced rat paw edema method was employed. The in-vitro antioxidant activity of the new derivatives was determined using the DPPH assay method with ascorbic acid as a standard drug. Regarding docking, most compounds exhibited good binding affinity, equal to or greater than that of the standard. All derivatives demonstrated moderate to good anti-inflammatory activity both in-vitro and in-vivo. They showed mild to moderate antioxidant activity compared to ascorbic acid. In conclusion,...
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Posted by admin on Oct 31, 2025 in |
Alcohol dependence syndrome (ADS) is an important condition causing significant morbidity and mortality contributing to 20-30% of all hospital admissions in India. There are various pharmacological agents available that are equally effective in the treatment of ADS along with psychotherapy. Hence this study is conducted. This is a cross-sectional study conducted in the inpatient department of Psychiatry, Victoria hospital, Bangalore for a period of 4 months. 70 study participants diagnosed with alcohol dependence syndrome willing to give written informed consent were enrolled. Demographic profile and treatment details were noted in a pre-structured case proforma. Data was analyzed and represented using descriptive statistics. The mean age of study participants was 39.38 ± 10.59 years, with a male predominance (98.57%) and mean duration of alcohol dependence was found to be 6.55 ± 0.55 years. 73% of Study participants were diagnosed with ADS alone whereas 27% had ADS along with comorbidities such as psychosis, alcoholic hepatitis, seizures, delirium tremens, diabetes mellitus and hypertension which were treated accordingly. In this study a combination...
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Posted by admin on Oct 31, 2025 in |
Genitourinary tract infections (GUTIs) are a common health concern among females of reproductive age, with significant implications for reproductive and overall health. These infections can lead to complications such as Pelvic Inflammatory diseases, Pyelonephritis and Chronic kidney failure. Furthermore, this leads to poor social and economic impact, particularly in developing nations such as India. The study was conducted to assess the prevalence and drug utilization patterns in the treatment of GUTIs in this population. A cross-sectional analysis was conducted across a diverse cohort of 500 females aged 18-45 years visiting the tertiary care center in Lucknow, Uttar Pradesh, India. Data were collected on the frequency of GUTI symptoms, types of infections, commonly prescribed medications, and adherence to treatment regimens. The results indicate a high prevalence of urinary tract infections (UTIs) and bacterial vaginosis, with significant variability in drug prescription patterns. The results of the study highlighted the concerns regarding antibiotic overuse and resistance. Factors such as age, socioeconomic status, and comorbid conditions were found to influence both infection rates...
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