Posted by admin on Apr 30, 2025 in |
Medicinal plants play pivotal roles in novel drug discovery or combinatorial drug surveillance against emerging infectious diseases. This study aims to explore and compare the bactericidal and antibiotic modulating activities of stem barks of Gmelina arborea Roxb. and Oroxylum indicum (L.) Kurz against two pathogenic bacterial strains, i.e., Escherichia coli and Staphylococcus aureus. Methanolic stem bark extracts of G. arborea and O. indicum were subjected to phytochemical analysis, DPPH antioxidant assay, and varieties of antibacterial assays (disc diffusion, agar well diffusion, modified agar well diffusion, and bacterial cell viability), and the results were compared. Phytochemical analysis revealed that both plants had major bioactive compounds like alkaloids, terpenoids, phenol & tannins, steroids, glycosides, etc. G. arborea had a total phenol content (TPC) of 27.33±8.60 mg/g of Gallic Acid Equivalent (GAE) and a total flavonoid content (TFC) of 72.33±4.90mg/g of Rutin Equivalent (RE). At the same time, O. Indicum was calculated to have a TPC of 48.58±1.80 mg/g of GAE and TFC of 269±0.88mg/g of RE. Though both stem barks exhibited...
Read More
Posted by admin on Apr 30, 2025 in |
Water is an essential ingredient for all living things to exist on earth. Ancient Siddha texts suggest that soaking some therapeutic plants may purify water. The current study aims to assess the water quality after being soaked with Terminalia chebula (Kadukkai) and Terminalia bellerica (Thantrikkai). Three distinct pots containing two liters of drinking water each were taken from Chembaramapakkam Lake and designated as samples A, B, and C. As a control group, Sample A was left behind. In the same setting, 50g of Terminalia chebula is soaked for 6 hours in the sample B container, and 50g of Terminalia bellerica is soaked for 6 hours in the sample C container. All filtered samples were then subjected to elemental analysis, microbiological testing, and physical inspection as per the drinking water standard methodology. The water treated with Terminalia chebula and Terminalia bellerica had improved color, odor, pH, hardness, alkalinity, and conductivity within allowable bounds. Elemental analysis showed elevated calcium levels, NO2 below the detection limit, and Cl, SO4, and Fe within...
Read More
Posted by admin on Apr 30, 2025 in |
The research rigorously investigates the bioactive potential of Cynodon dactylon, specifically focusing on its antipyretic properties attributed to quercetin, a flavonoid compound. Cynodon dactylon, a perennial grass, has been traditionally used in various medicinal practices, prompting scientific inquiry into its pharmacological benefits. The study involved meticulous extraction and isolation of quercetin from Cynodon dactylon using advanced solvent extraction and chromatographic techniques. The purity and structure of the isolated compound were unequivocally confirmed through rigorous spectroscopic methods, including UV and NMR analyses, ensuring the absolute reliability of the isolated quercetin for subsequent pharmacological evaluations. An in vivo experimental model using pyrexia-induced rodents was employed to robustly assess the antipyretic activity of Cynodon dactylon extract and isolated quercetin, comparing their efficacy with standard antipyretic drugs. The results unequivocally indicated a significant reduction in elevated body temperature in the treated groups, conclusively demonstrating the remarkable effectiveness of Cynodon dactylon and its quercetin component in reducing fever. The study concludes that quercetin isolated from Cynodon dactylon exhibits notable antipyretic activity, unequivocally validating its...
Read More
Posted by admin on Apr 30, 2025 in |
This descriptive observational study was conducted at Government Medical College and Dr. Susheela Tiwari Memorial Government Hospital, Haldwani, Uttarakhand, to evaluate the seroprevalence and clinico-epidemiological profile of chronic Hepatitis B (HBV) and Hepatitis C (HCV) among patients. Over a two-year period, 7,149 outpatients were screened, identifying 38 HBV-positive cases (0.53%) and 141 HCV-positive cases (1.97%). Patients were assessed using detailed clinical evaluations, laboratory tests, and imaging studies, with data analyzed through SPSS. The majority of patients with HCV presented with advanced liver disease, as evidenced by higher rates of ascites (13.97%), jaundice (11.73%), and elevated urea levels (p=0.03), while HBV patients exhibited significantly higher serum bilirubin (p=0.005) and SGOT levels (p=0.0057). Sociodemographic analysis revealed no significant differences in age, gender, or education between groups, but geographic patterns showed HBV predominance in Nainital (63.2%) and HCV dominance in Udham Singh Nagar (27.7%) and Bijnor (29.1%). These findings underscore the urgent need for targeted interventions, including awareness campaigns, preventive measures, and region-specific healthcare strategies, to reduce the burden of viral hepatitis...
Read More
Posted by admin on Apr 30, 2025 in |
The renal system helps in the urinary excretion of drugs in unchanged form or metabolites. Since a majority of the drugs are eliminated by the kidneys, impairment in renal function can lead to drug accumulation, toxicity, and therapeutic failure. As a result, patients with impaired renal function require careful dose modifications. The purpose of this study was to determine the most frequently prescribed dose-unadjusted antibiotic and to assess the appropriateness and rationality of antibiotic dose adjustments in patients with Chronic Kidney Disease (CKD). Additionally, the study aimed to pinpoint the factors contributing to incorrect dosing adjustments. A retrospective observational study was conducted from December 2022 to November 2023 and medical records of the study subjects admitted to the nephrology department of Mallige Medical Centre, Bengaluru, were reviewed for antibiotic prescriptions. This study included 651 participants in total, with a p < 0.05 level for statistical significance. The findings showed that 35 different antibiotics were prescribed to patients with CKD, with 71.42% (25/35) requiring renal dose adjustments. Notably, 51% (332/651)...
Read More
