Posted by admin on Apr 30, 2025 in |
The synthesis of metal oxide nanoparticles has emerged as a burgeoning field of research due to its promising applications in advancing technological frontiers. Particularly, the utilization of biologically derived nanomaterials has gained significant traction within the realm of nanotechnology. Tamarindus indica plant extract has demonstrated efficacy as a viable precursor for the synthesis of silver nanoparticles. Tamarindus indica, being a locally abundant plant, boasts a rich composition of essential amino acids and vitamins. This investigation presents the biosynthesis of metal oxide nanoparticles using an aqueous extract derived from Tamarindus indica. The aqueous extract and resultant nanoparticles underwent comprehensive characterization techniques such as XRD, DLS, UV, SEM, and EDS. Additionally, this study delves into the antimicrobial properties of the synthesized compound. By minimum inhibitory concentration (MIC) and Agar diffusion method of the extract against various test organisms was conducted, with results indicating antimicrobial activity against both gram-positive and gram-negative bacteria as well as fungi. The efficacy of the antimicrobial effect was assessed by measuring the diameter of the inhibition zone....
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Posted by admin on Apr 30, 2025 in |
Background: Patients with respiratory diseases are frequently treated with inhaled corticosteroids (ICS) to lower the likelihood of exacerbations. Research to date indicates that ICS treatment has a significant impact on eosinophils counts, which is a phenomenon with wider consequences. Therefore, to maximize the benefits of ICS therapy, it is necessary to investigate the intricate interplay between ICS and eosinophils. Aim and Objective: Our research aimed to assess the influence of inhaled corticosteroids (ICS) on eosinophils counts, as well as the safety and adherence of ICS therapy. Materials and Methods: The single-centered prospective observational study was conducted over three months with 69 patients. The sociodemographic and clinical information were recorded. The ICS’s safety and adverse effects were evaluated using the Inhaled Corticosteroid Questionnaire (ICQ). The Morisky Medication-Taking Adherence Scale-MMAS (4-item) was used to evaluate the medication-taking behavior. Statistical significance was defined as a P < 0.05. Results: Of 69 patients, 42 were in the study arm (with ICS) and 27 in the control arm (without ICS). The mean age of the study arm was 55.2 years,...
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Posted by admin on Mar 31, 2025 in |
Levocetirizine Dihydrochloride is an orally active, non-sedative antihistamine drug. To determine the assay content of Levocetirizine Dihydrochloride drug substance, a very simple, accurate, specific, and precise UV-Spectrophotometric method has been built up as well as evaluated. The suggested method comprises dissolving Levocetirizine Dihydrochloride in distilled water and subjecting the consequential solution to UV Spectroscopic measurement. An absorption maximum was found to lie at about 230 nm and the measurements were carried out at this wavelength. Beer’s law was followed in the concentration range of 4 to 32 μg/ml. The linearity showed on the calibration curve between concentration and absorbance by the line equation of y = 0.0304x + 0.0002 (R² = 0.9997). Reproducibility by repeating methods as %RSD was found to be less than 2%. The results of the accuracy and precision were found very satisfactory and here the suggested method was statistically validated as per the ICH guidelines in terms of specificity, linearity, accuracy, precision and robustness. Validation studies have discovered that the method is simple, specific, rapid,...
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Posted by admin on Mar 31, 2025 in |
Postpartum hemorrhage (PPH) is one of the leading causes of maternal morbidity and mortality, ranking third after throm-boembolism and hypertensive disorders. The primary goal of this study was to determine the effectiveness of balloon tamponade in the prevention and treatment of postpartum hemorrhage. The principle of balloon tamponade is to apply direct pressure to the bleeding vessels of the placental area using the wall of an inflated balloon within the uterus. The basic study included both retrospective and prospective research. The retrospective study group (no balloon tamponade performed) consisted of 72 patients, of whom 34 delivered vaginally and 38 underwent cesarean section. The prospective study group (balloon tamponade performed) included 40 women (20 with vaginal deliveries and 20 with operative deliveries). The effectiveness of the treatment was assessed based on two criteria: the volume of blood loss and the number of hysterectomies performed. In our study, the effectiveness of balloon tamponade was found to be 95%, based on the complete cessation of bleeding and the reduction in the length...
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Posted by admin on Mar 31, 2025 in |
Introduction: Adverse events following immunisation (AEFI) are frequently underreported in India for numerous reasons, ultimately impacting the country’s immunisation program. The current study evaluates the knowledge, attitudes, and reporting practices (KAP) on vaccine vigilance among physicians in our hospital. Objectives: To find out various causes of Under-reporting of adverse events subsequent immunisation. Materials & Methods: Using a standard questionnaire, 200 doctors were interviewed. Responses were documented and analysed. Doctors had 37.8% knowledge while 68.9% had a good attitude but had poor reporting practices 34.6%. Results: Lack of knowledge, difficulty in filling reporting form, time constraints were the common causes for the under-reporting. Conclusion: Enhancing the perspective of AEFI, adequate training, and proactive involvement in reporting by healthcare practitioners could strengthen the nation’s vaccine surveillance...
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