Posted by admin on Dec 31, 2023 in |
Background: Having a satisfaction assessment tool that is reliable and valid is paramount in patient satisfaction research. Objective: To develop an instrument to assess the satisfaction of HIV-infected persons covering different aspects of health service delivery in Nigerian HIV treatment hospitals. Materials and Methods: The questionnaire items were developed from literature as well as from key themes identified by Nigerian patients as been most important in the delivery of high-quality care as reported in a systematic review. The following factors were assessed: construct validity, factorial validity, reliability, face and content validity, and practicality. Bishop Shanahan Hospital Nsukka evaluated the instrument’s viability, and a tertiary healthcare facility validated it. Principal components and varimax rotation were utilized in factor analysis. Utilizing internal consistency and Cronbach’s alpha, reliability was examined. Spearman’s rho correlation was used to determine the convergence and discriminant validity. Results: A 10-item questionnaire was developed in a band score of 0-10 response options. ‘’0’’ indicates complete dissatisfaction and ‘’10’’ denotes complete satisfaction. Ninety questionnaires were collected for the pilot...
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Posted by admin on Dec 31, 2023 in |
Avian salmonellosis is a large group of acute or chronic diseases of birds caused by different species of the genus Salmonella. It is a problem of economic concern for all phases of the poultry industry, from production to marketing. The main aim of this study is to investigate the incidence of Salmonella species in the feed and environment of open-system poultry farms. A total of 46 samples were taken from six poultry farms, layers and broilers. The samples include poultry feed from feeders (23 samples) and litter (23 samples). Isolation of Salmonella was carried out in a selective classical medium (DCA) after enrichment in Selenite-F broth. Four Salmonella isolates represent 5% of total samples were recovered; three isolates (75%) from litter samples and one isolate (25%) recovered from water samples; no Salmonellae were recovered from feed samples. All isolates were identified at the species level using cultural characteristics and biochemical reactions. An antimicrobial sensitivity test for the four Salmonella isolates was carried out. Each isolate was tested to 10...
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Posted by admin on Dec 31, 2023 in |
CADD is a powerful method to discover possible therapeutic compounds in conventional drug discovery. It has now surpassed all other high-throughput screening options, commonly used in drug discovery and development. The creation and optimization of several clinically utilized medications have significantly advanced thanks to CADD, or computer-aided drug design. Computer-aided drug design can take one of two methods: (1) Ligand-based (Analogue based) or (2) Structure-based (Target Based). All of these methods rely on MM force fields to represent atomic-level interactions and define molecular shapes, energy, and motion. The two most common approaches to drug design are structure-based drug design and ligand-based drug design. We can learn about drug-receptor interactions from it. Structure-based drug design includes the discovery of binding sites as well as docking and stocking, virtual screening, compound selection, and lead optimization. Quantitative structure-activity relationships (QSAR), pharmacologic modeling and other processes are aspects of the structure-based drug design process. As can be seen, CADD assists in recognizing appropriate pharmacological properties and compatibility to get an advantage in pre-clinical...
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Posted by admin on Dec 31, 2023 in |
Introduction: This paper will provide an overview of the uses, advantages and disadvantages of using ChatGPT in the pharmacy. A new era of personalised and interactive learning is beginning in pharmaceutical education because of ChatGPT (Generative Pre-trained Transformer). Through the use of AI technology, ChatGPT provides adaptive tutoring that enables students to advance at their own speed and receive individualised guidance. Their understanding is improved, and it also encourages a more intense level of engagement. Methods: This study discuss how ChatGPT is very important in enhancing inclusion and accessibility in pharmaceutical education. It explore the incorporation of virtual simulations and practical training fills the gap between academic understanding and real-world application by giving students practical experience before they reach the workforce. It also addresses the importance of considering ethical issues, such as data privacy, bias correction, and finding the right balance between human engagement and technology when using AI in education. Results: The abstract highlights various studies that demonstrate the effective inclusion of ChatGPT in pharmaceutical education. Numerous studies...
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Posted by admin on Dec 31, 2023 in |
A simple, novel, precise, rapid, accurate, specific reverse phase high performance liquid chromatography (RP-HPLC) method for estimation of Teneligliptin hydrobromide hydrate and Dapagliflozin propanediol monohydrate API in marketed formulation was developed and validated. The separation was carried out on a Prontosil C18 (250 x 4.6 mm, 5 m) column using an acetonitrile: 3.5 pH Potassium dihydrogen phosphate buffer (60:40 v/v) mobile phase. The flow rate was 1 mL/min, and the UV detector was set to detect at 227 nm. Teneligliptin Hydrobromide Hydrate retained 2.37 min, while Dapagliflozin Propanediol Monohydrate retained 3.61 min. Teneligliptin hydrobromide hydrate revealed a linear response in the concentration range of 10-30ppm. In the concentration range of 5-15ppm, dapagliflozin propanediol monohydrate demonstrated a linear response. Teneligliptin hydrobromide hydrate and Dapagliflozin propanediol monohydrate had correlation coefficients (‘R2‘ value) of 0.999 and 0.992, respectively. Various validation parameters were used to validate the analysis results. Teneligliptin hydrobromide hydrate and Dapagliflozin propanediol monohydrate percentage recoveries vary from 98% to 101%. Both precision and robustness study found to have % RSD...
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