Posted by admin on Dec 31, 2023 in |
Medicinal plants are enriched with biological substances that are proven to be a direct or indirect source of modern drugs. The relevance of the exploration of new natural reservoirs of pharmaceutical potential has increased immensely after COVID-19. The present study deals with the extraction of flavonoids from selected plants i.e. Ricinus communis, Euphorbia hirta and Croton bonplandinum from the family Euporbiaceae by following conventional and non-conventional techniques. The conventional and non-conventional method includes Soxhlet extraction and Ultrasonic Assisted Extraction, respectively. Significant and comparable results were obtained for the ultrasonic technique in terms of the total quantity of extracts. The quantity of total flavonoid extract from the root, stem of Ricinus communis and stem, fruit, and root of croton bonplandinum is much greater in UAE (4.8mg/gdw and 36.9mg/gdw, respectively; 8.9mg/gdw, 60.5 g/gdw, 10.7 mg/gdw respectively) than Soxhlet method (0.95 mg/gdw and 4.8 mg/gdw respectively; 0.99 mg/gdw, 13.54 mg/gdw and 1.29 mg/gdw, respectively). The higher quantity of total flavonoids was recorded to be more for all extracts of Euphorbia hirta by...
Read More
Posted by admin on Jan 18, 2023 in |
Phytosomes is vesicular drug delivery system in which phytoconstituents of herb extract surround and are bound by lipid. Hexadecanoic acid is the phytoconstituents of Nigella sativa oil. Hexadecanoic acid is hydrophobic and possesses less solubility and permeability. The study aims to formulate, optimize, and evaluation of hexadecanoic acid phytosomal gel for anti-fungal activity hexadecanoic acid loaded phytosomes were prepared using Thin film hydration method and were optimized using factorial design (32) using Design-expert® software (Version 7.0.0, Stat-Ease Inc., Minneapolis, USA) different formulations were prepared. Two different independent variables were used, which include: Amount of Soya lecithin (X1), amount of cholesterol (X2) and the responses are particles size determination (Y1), and entrapment efficiency (Y2). The optimized formulation of hexadecanoic acid phytosomes was incorporated into a Carbapol 934 gel base and 1.5% of hexadecanoic acid phytosomal gel was prepared which was evaluated for drug content, pH, Spreadability, viscosity and in-vitro drug release. The prepared hexadecanoic acid phytosomes had a maximize EE% was found to be (72.23%), particle size was found to...
Read More
Posted by admin on Dec 31, 2022 in |
Nutraceutical is a word obtained from Nutrition and Pharmaceuticals. Nutrients are a feed constituent that helps to support the life of human beings or animals. Pharmaceutical components are non-toxic food constituents, including prevention and treatment of disease. They commonly inhabit the disorders associated with oxidative stress, for instance, cardiovascular disease, Diabetes, and Hypertension. Nutraceuticals possess substantial importance because of their expected safety and possible nutritional and therapeutic effects. Hypertension is the most frequent risk factor for cardiovascular disease involving coronary heart disease and stroke. There is a crucial role in utilizing single and integral nutraceutical supplements, vitamins, antioxidants, and minerals in the treatment of hypertension. These food supplements rein huge demand because they are less toxic and have long life treatment with dietary food. We have done a face-to-face survey on 33 medical stores. The survey results found that the most demanding nutraceutical is Mactotal, and the least demanding nutraceuticals are Beryl tone and Allvell-Z graph seed extract. The survey study also shows a list of Nutraceuticals that are...
Read More
Posted by admin on Dec 31, 2022 in |
In the present study, phytochemical and pharmacological properties of species of F. benjamina have been discussed. The phytochemical and pharmacological properties correlate with various active constituents of the plant. Ficus belongs to the Moraceae family, found in Asia and Australia, and widely distributed in tropical and subtropical areas, including more than 800 species. The genus Ficus constitutes a major tree group with numerous chemical constituents of promising medicinal value. Morphological characteristics of the plant show that it is a fast-growing plant and moderate to high-temperature conditions are more favorable for the fast growth of the plant. A microscopical study has shown the existence of various cells. Different plant parts have been extracted using different solvents and many bioactive compounds, chiefly stigmasterol, quercetin, cinnamic acid, lactose, naringenin, caffeic acid extracted, and isolated from roots, fruits, leaves and barks. Ficus benjamina is used by distinct native population groups in many ways as its bark, leaves, roots, fruits, and stem shows various therapeutic uses. Additionally, the stem and bark latex also shows...
Read More
Posted by admin on Dec 31, 2022 in |
A facile, highly efficient, simple, and convenient method for synthesizing 2, 4, 5-trisubstituted imidazole derivatives from the condensation of various substituted benzaldehyde, benzil, and ammonium acetate by using a catalytic amount of PEG-SOCl in the presence of water at room temperature or under microwave irradiation. PEG-SOCl is an effective heterogeneous catalyst and easy to separate. We have investigated that PEG-SOCl catalytic system was excellent recycled and reused three times without any loss of catalytic activity. PEG-SOCl act as a green catalyst, low-cost, non-volatile, non-hazardous, environmental friendly catalyst, and water is a green solvent reaction carried out at room temperature or under microwave radiation method shows greater advantages because it has contributed in the green chemistry aspects. The prepared catalyst was analyzed by analytical methods such as infrared spectrum (IR), X-Ray diffraction pattern (XRD), thermo-gravimetric analysis (TGA), and BET surface analysis. Spectroscopic techniques identified the synthesized pure product (1j), including infra-red (IR) spectrum, 1H and 13C NMR spectrum and Mass (LC-MS)...
Read More
