Posted by admin on Dec 31, 2019 in |
Analytical method for simultaneous estimation of Ertugliflozin (ERT) and Metformin hydrochloride (MET) was developed and validated by high-performance liquid chromatography (HPLC) as per ICH guidelines. The drugs were injected into the inertsil C18 (250 × 4.6 mm) maintained at room temp and wavelength 220 nm. The mobile phase consists of buffer (potassium dihydrogen pH 4.0) and methanol (65:35 v/v). The flow rate is maintained at 1.0 mL/min. The calibration curve was linear and regression coefficient (R2) value was found to be 0.999 and concentration ranging from 1.5-4.5 µg/mL and 100-300 µg/mL for Ertugliflozin and Metformin hydrochloride respectively. The LOD and LOQ of the method were found 1.04 μg/mL, 9.61 µg/mL and 0.0007 µg/mL, 0.006 µg/mL for Ertugliflozin and Metformin HCl. The developed method was found to be simple, precise, specific, linear and accurate as validated as per USP and International Conference on Harmonization (ICH)...
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Posted by admin on Dec 31, 2019 in |
Arnebia benthamii (synonym – Microtomia benthamii) commonly known as Ratanjot or Laljari found in western Himalayan region and used as wound healer roots by local vaids and tribes. The roots of Arnebia benthamii contain a red dye that is used in various health disorders like fungal infection, inflammation, fever and coloring/flavoring agent in Indian curries. To estimate wound healing potential of root extract of Arnebia benthamii, percentage wound contraction, wound area, epithelization time, tensile strength and wound index were measured in 13 days of wound healing study. The results showed highly significant wound healing in excision as well as incision wound healing models (P<0.01). The Arnebia benthamii extract-treated wounds showed about 41% higher wound contraction rate and 44% increased tensile strength in comparison with negative control animals. The epithelization time decreased by 43% and wound index value decreased by 89% in comparison to negative control animals which indicated that methanolic root extract of Arnebia benthamii is very helpful in faster and high-quality wound healing (P <...
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Posted by admin on Dec 31, 2018 in |
Objective: To evaluate and compare pH and titrable acidity (TA) of various commonly consumed commercially available soft drinks. To evaluate and compare the weight of enamel dissolution and surface micro-hardness of the tooth after exposure to commonly consumed commercially available soft drinks. Methods: 60 human enamel specimens were randomly divided into 5 groups: Group 1: Kinley water (control), Group 2: Pepsi cola, Group 3: Urzza the liquid charger, Group 4: Tropicana orange delight, Group 5: Patanjali amla amrit. For the five solutions pH and TA was calculated. Each of the specimens were then pre-weighed and exposed to the soft drink for 14 days and weighed again. The mean weight difference was calculated for all of the samples. The same samples were subjected to the micro-hardness test (Vickers hardness number). Results: The pH of all the test drinks ranged from 2.55 to 3.74, which is far below critical pH. The pH and TA of carbonated drinks were statistically significantly lower than non-carbonated groups. Statistical analysis revealed that TA at 5.5...
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Posted by admin on Dec 31, 2018 in |
Atorvastatin alginate beads were prepared by ionic gelation method by using different curing agents and studied the different process variable like the effect of alginate concentration, the effect of rpm and curing agents on drug entrapment and to improve the bioavailability of the drug. The beads examined and qualified the all compatible studies. The amount of drug released in acidic medium was found to be less than alkaline medium and proved drug release is function of surrounding pH effect and beads prepared with aluminium chloride with physical mixture of sodium alginate and carbopol 934P at proportions of 3.3% produces more compacted, stabled and shows prolonged sustained release in comparison to barium chloride at same concentration of polymers. The size of beads, drug entrapment, and drug release depend upon variables like alginate concentration, type of curing agent, rpm, the valence of curing agent and addition of copolymer. The drug entrapment and physical stability will be improved by adding carbopol 934P along alginate polymer. DSC studies clarify Atorvastatin was dispersed in...
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Posted by admin on Dec 31, 2018 in |
The objective of this research was to develop a liquisolid (LS) formulation of dl-α tocopherol acetate with improved dissolution properties and evaluate its strength to excipient modifications as well as its stability. Microcrystalline cellulose (MCC) and sodium starch glycolate (SSG) was employed as carrier material and disintegrant respectively for preparing LS compacts. Colloidal silicon dioxide (CSD) was selected as coating materials. All the precompression parameters such as tapped density, bulk density, carr’s index, hausner’s ratio and angle of repose show the good flow properties of the formulation. UV and FTIR evaluated the physicochemical properties of the liquisolid system. All studies revealed that no interaction between drug and the carrier. The drug release rates of liquisolid compacts were specifically higher as compared to regular tablets. The specific surface areas of coating materials affected the flow properties of the blends, and the particle sizes of coating materials affected the dissolution rate. The selected formulation demonstrated stability for atleast 3 months. The F3 formulation is found to be the optimized formulation. The...
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