Posted by admin on Dec 31, 2017 in |
Cefixime trihydrate belongs to third generation cephalosporin having poor water solubility. In the present study, nanocrystal suspensions of cefixime trihydrate were prepared with the objective of providing enhanced solubility and stability with reduced particle size and thus improving the bioavailability potential. Nanocrystal suspensions were prepared by high pressure homogenization technique and evaluated for particle size, polydispersity index, zeta potential, and drug release. 23 factorial design was used for the formulation designing purpose. Particles of average size 143.5nm having PDI of 0.269 were produced. Zeta potential was found to be -36.6mV and the formulation was found stable on the basis of results obtained from differential scanning calorimetry and scanning electron microscopy studies. The drug release and ex-vivo permeation studies revealed enhanced permeation of drug, as desired, indicating its potential for an attempt towards successful nanocrystal...
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Posted by admin on Dec 31, 2017 in |
The medicinal plants are the key source in the life of human beings. The present study was aimed to evaluate the preliminary phytochemistry, pharmacognostical and antimicrobial activity of Canthium coromandelicum fruit. The fruit showed the presence of secondary metabolites like flavonoids, steroids, tannins, phenol, sterols, cardiac glycoside and saponin glycoside in various extracts. The pharmacognostical analysis of C. coromandelicum was useful in the identification of authentic samples and recognizing adulterants. The various extracts of C. coromandelicum fruit has shown antimicrobial activity against eight bacterial strains including Gram negative, Gram-positive bacteria, and three fungal strains using agar well diffusion method. The methanolic extract showed the broad spectrum antimicrobial activity compared to petroleum ether and chloroform extracts. Chloroform extract showed high cytotoxicity value with low IC50 values. The antimicrobial studies proved that Canthium coromandelicum fruit has antimicrobial activity against the selected pathogens. The Brine Shrimp Lethality Assay is an excellent predictive tool for the toxic potential of plant extracts in...
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Posted by admin on Dec 31, 2016 in |
Proniosomes based drug delivery systems have potential as a significant drug carrier in a variety of therapeutic applications. The objective of the present study was to investigate in vitro sonophoretic transdermal delivery of Losartan Potassium (LP) across albino rat skin using proniosomal gel and its comparison with aquasonic gel. Proniosomes of LP were fabricated with L-a-lecithin (egg yolk), cholesterol and a non-ionic surfactant and confirmed using optical microscopy. Permeation experiments were performed using modified Franz Diffusion Cell along with ultrasound treatment (Frequency-1MHz; Intensity- 2.5 W/cm2; Duration of application- 30 min; Mode of application – Continuous and Pulsed). An in vitro skin permeation of LP with aquasonic gel was found superior than proniosomal gel using sonophoretic delivery. Using proniosomal gel, when ultrasound was applied in pulsed mode, LP transdermal flux and enhancement factor were 60.88 ± 6.2 μg/cm2/h and 5.31, respectively, 115.41 ± 5.01 μg/cm2/h and 10.07 those achieved using aquasonic ultrasound gel, respectively. Similar results were observed (better flux with aquasonic gel than proniosomal gel) using continuous mode of...
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Posted by admin on Dec 31, 2016 in |
Anti-diabetic activity of hydro-alcoholic extract of Chrysophyllum cainito frutis (CCE) was investigated against experimentally induced diabetics in rats using alloxan and streptozotocin (STZ). Acute toxicity study was performed and hydro-alcoholic extract of CCE was found to be safe at a dose of 2000 mg/kg bodyweight. Two doses 200 mg/kg and 400 mg/kg b.w p.o. of the CCE were subjected for the evaluation of anti-diabetic activity against the diabetic induced by alloxan (100 mg/kg, i.p) and STZ (50 mg/kg, i.p) in rats. Glibenclamide (5 mg/kg p.o) was served as standard in both the models. Fasting blood glucose, serum total cholesterol, serum triglycerides, lipid profile (HDL and LDL) and histopathology were evaluated in the study. Both the lower (200 mg/kg) and higher dose (400 mg/kg) of CCE showed a dose dependent significant decrease in blood glucose level, triglyceride, cholesterol levels and LDL and an increase in HDL in the treated diabetic rats when compared with diabetic control. Histopathology of pancreas showed regeneration of β-cells in extract treated diabetic rats. The results...
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Posted by admin on Dec 31, 2016 in |
Preeclampsia usually develops systemic hypertension, proteinuria, coagulation abnormalities and eclampsia develops when convulsions superimpose on the syndrome of preeclampsia. Disturbed renal functions with elevated blood urea and serum creatinine levels were reported in various studies but, elevations of serum uric acid levels are controversial. The aim of the current study is to determine the renal function Parameters such as blood urea, serum creatinine and serum uric acid levels in preeclampsia patients and to compare it with the normal pregnant women. 100 subjects were selected with 50 controls and 50 preeclampsia cases. Renal function parameters are estimated in preeclampsia cases and controls (normal pregnant women). Statistical analysis was done. The study may be concluded that the uric acid levels are elevated along with urea and creatinine in preeclampsia compared to normal pregnancy...
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