Posted by admin on Dec 31, 2016 in |
Plant extract-mediated biosynthesis of nanoparticles has proven to be a novel, rapid, cost-effective, non-toxic and eco-friendly method. For the first time, biological material in the form of aqueous extract of Annona muricata fruit (AMF) was successfully utilized for the synthesis of silver nanoparticles (AgNPs). The various parameters such as metal ion concentration, volume of the extract, temperature, reaction time and pH influencing nanoparticle synthesis have also been optimized. The structural and elemental components of the synthesized AgNPs were characterized. The UV-vis spectra gave surface plasmon resonance peak at 421nm. Fourier transform infrared spectroscopy (FTIR) revealed capping of nanoparticles with plant constituents. X-ray diffraction (XRD) demonstrated a face-centered crystalline nature with an average size of 19 nm. Field Emission scanning electron microscopy (FESEM) showed their spherical shape and the presence of elemental silver were determined by Energy Dispersive X-ray spectroscopy (EDX). Further, assessment of the antioxidant activity, total phenolic content and photocatalytic property of biogenic silver nanoparticles attest to their utility for several biomedical and industrial...
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Posted by admin on Dec 31, 2016 in |
The phytochemicals of various parts of the plants mainly the secondary metabolites are well known for its high potential therapeutic values such as antifungal, antibacterial, anti-inflammatory, anticancer, antiplasmodial, antioxidant, insecticidal etc. In the present investigation an attempt was made to analyze the various phytochemicals present in Artemisia nilagirica (Clarke) Pamp which is wide spread and commonly grown for its religious importance and fragrance through GC-MS. Methanolic leaf extract of the A.nilagirica (Clarke) Pamp revealed eight different compounds and the structures were predicted and recorded. The phytoconstituents of the target extract revealed high medicinal values in the pharmaceuticals industries. These compounds were separated by column chromatography for further authentication of the therapeutic...
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Posted by admin on Dec 31, 2016 in |
The present study was aimed to evaluate the anti-oxidative defence system of Hydnocarpus laurifolia in diabetic rats and its potential effect against the β-cell damage induced by oxidative stress. Hydnocarpus laurifolia is a plant which belongs to the family Flacourtiaceae. According to the Indian system of traditional medicine it is used in the treatment of diabetes mellitus. Also literature reveals that the plant possesses anti-inflammatory, anti-leprotic and anti-oxidant property. Type II diabetes was induced in Wistar rats (180-250 gms) by intra peritoneal injection of Streptozotocin (STZ) at 30 mg/kg body weight. Diabetic rats were orally administered with ethylacetate extract of H.laurifolia (EEHL) at two different doses of 100 and 300 mg/kg body weight. Serum glucose and insulin levels were determined. The in vivo anti-oxidant study was determined by evaluating enzymatic anti-oxidants such as Superoxide dismutase (SOD), Lipid peroxidase (LPO) and Catalase (CAT) in hepatic tissue of STZ induced diabetic rats.The MDA levels were depleted and SOD and CAT enzymes were restored in diabetic rats treated with EEHL at the...
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Posted by admin on Dec 31, 2016 in |
Bryophytes- the small, slow growing group of plants is stockroom of naturally occurring materials. They contain a high number of biologically active compounds, however their use as a natural fungicides is negligible. In the recent years bryophytes has emerged as a potential biopharming tool for production of complex biopharmaceutiticals. In order to evaluate potential use of bryophytes as an antifungal compounds their basic chemical contents and the secondary metabolite profile was determined. Among secondary metabolites flavonoids are a group of polyphenolic compounds, which are widely distributed throughout the plant kingdom. Flavonoids like Rutin and quercetin possess many biochemical effects. An HPLC method was developed for the estimation of quercetin from methanol extract of Philonotis revoluta bryophyte. The results of the phytochemical screening using different extracts revealed the presence of alkaloids, flavonoids, phenols, etc. in the moss plant and investigated against plant pathogenic fungi using different parameters. Results showed significant reduction in pathogenic...
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Posted by admin on Dec 31, 2016 in |
Reactive oxygen species (ROS) are inevitable by-products of cellular respiration. These are highly reactive chemical species derived from molecular oxygen (O2). These include the superoxide (O2−) and hydroxyl (HO−) free radicals as well as non-radical molecules such as hydrogen peroxide (H2O2). These act as both toxic and beneficial compounds, since they can be either harmful or helpful to the body. Redox regulation or controlled ROS generation is the net effect of a subtle balance between ROS generation and neutralization or utilization by cellular antioxidant systems. The most deleterious effect of ROS is “oxidative stress”. Oxidative stress plays a major part in the development of chronic and degenerative ailments such as cancer, arthritis, aging, autoimmune disorders, cardiovascular and neurodegenerative diseases. Several mechanism exists to counteract oxidative stress. This review provides a detailed overview of the influence of ROS on human pathophysiology and novel therapeutic strategies followed to treat ROS mediated diseases or...
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