Posted by admin on Oct 1, 2013 in |
Hyaluronic acid is an important naturally occurring polysaccharide present in extracellular matrices. The network-forming, viscoelastic and the charge characteristics of hyaluronic acid are important to many biochemical functions of living tissues. Its involvement in many diseases such as cancer, arthritis and osteoporosis, and the fact that it has specific protein receptors present on the cell surfaces, has given new impetus in drug design and synthesis of hyaluronic acid-drug conjugates. As a general arrangement, the review will focus on structure and conformation of hyaluronic acid, its chemistry and chemical methodologies that have led to a number of important hyaluronic-drug...
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Posted by admin on Oct 1, 2013 in |
Most of the traditional systems of medicines are effective but the need is just to validate them to assess the quality, quantity and purity of the drugs. To support the same a polyherbal Ayurvedic powdered formulation Shatavaryadi churna used as immunomodulator, galactagogue, aphrodisiac and rejuvenator was taken for pharmacognostical, physicochemical and elemental investigation. Shatavaryadi churna is the composition of five ingredients, i.e. powder of Asparagus racemosus Willd. tubers-1part, Tribulus terrestris Linn. fruits- 1 part, Mucuna pruriens (L.) DC seeds- 1 part, Withania somnifera Dunal. roots- 1 part and Chlorophytum tuberosum Baker bulbs- 1 part. Ingredients of the formulation, In-house formulation and Marketed formulation have been pharmacognostically, physicochemically and elementally characterized by microscopy, physical constant values and Energy Dispersive Spectroscopy. Selected parameters for the investigation were anatomical study; powder microscopy; Extractive values i.e. alcohol soluble, water soluble, chloroform soluble, ethyl acetate soluble and petroleum ether soluble; Ash values i.e. total ash, water insoluble ash, acid insoluble ash; moisture content value, foreign matter and elemental content. The set parameters were found...
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Posted by admin on Oct 1, 2013 in |
Introduction: Melatonin is a neuro-hormone secreted from the pineal gland and involved in various regulatory activities in body. Ever-increasing use of melatonin supplements and enlarging research evidences make the authors undertook the review to arrive at a qualitative conclusion whether melatonin supplements can act as potential treatment options or not. Methodology: A comprehensive search was undertaken in different electronic databases using various search terms. A total of 225 studies were identified including clinical research studies and basic experiments. Data were extracted individually from the studies and compiled in the end. Results: Melatonin has been used successfully in chronic insomnia and as an anti-oxidant in cancer and other age-related neuro-degenerative disorders, especially Alzheimer’s disease and Autistic disorders. Its evidences of use in other conditions remained insufficient and inconclusive. Conclusion: Melatonin therapy may be considered as efficacious and safe in insomnia and as an anti-oxidant; however, other roles needs to be evaluated in further...
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Posted by admin on Oct 1, 2013 in |
On the basis of various literature survey, imidazole derivatives show various activity such as antimicrobial, anti-inflammatory, analgesic, antitubercular, anticancer etc. The possible improvements in the activity can be further achieved by slight modifications in the substituents on the basic imidazole nucleus. Having structural similarity with histidine imidazole compound can bind with protein molecules with ease compared to the some other heterocyclic moieties. Thus imidazole offers better pharmacodynamic characteristics. Furthermore, some imidazole drugs, at high concentrations, could exert direct inhibitory effects on membranes, without interference with sterols and sterol esters. Various recent new drugs developments in imidazole derivatives show better effect and less toxicity. Prompted by the broad spectrum activities of 2, 4, 5- triphenylimidazole derivatives, it was decided to synthesize various 2, 4, 5-triphenyl-1-substituted imidazoles and to evaluate them for their pharmacological...
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Posted by admin on Oct 1, 2013 in |
A simple, accurate and rugged stability indicating UV Spectrophotometric method was developed using methanol as the solvent to determine Rizatriptan Benzoate content in pharmaceutical dosage forms. The UV Spectrophotometric method for Rizatriptan Benzoate was determined at λmax 278nm and the drug proved linear in the range of 10-80μg/ml, with a good correlation coefficient of 0.9997. Percentage purity was found to be 99.94% and an excellent mean recovery (98.65%-100.7%). The method was validated statistically and it can be employed for the routine analysis of Rizatriptan benzoate in marketed...
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