Posted by admin on Oct 1, 2012 in |
The parenteral administration route is the most effective and common form of delivery for active drug substances with poor bioavailability and the drugs with a narrow therapeutic index. Drug delivery technology that can reduce the total number of injection throughout the drug therapy period will be truly advantageous not only in terms of compliance, but also to improve the quality of the therapy and also may reduce the dosage frequency. Such reduction in frequency of drug dosing is achieved by the use of specific formulation technologies that guarantee the release of the active drug substance in a slow and predictable manner. The development of new injectable drug delivery system has received considerable attention over the past few years. A number of technological advances have been made in the area of parenteral drug delivery leading to the development of sophisticated systems that allow drug targeting and the sustained or controlled release of parenteral...
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Posted by admin on Oct 1, 2012 in |
The use of bronchodilators has been increasing for the past few decades. The literatures have reported a high rate of adverse events. It has also been found out that beta-agonists are associated with an increased morbidity and mortality rate. Respiratory tolerance develops due to regular use of beta-agonists, which are widely prescribed in asthma and bronchiolitis also is of major concern. Objective: To evaluate the rational use of bronchodilator drugs by analyzing the appropriateness of the prescription. Methodology: Prospective observational study. Study site: A 500-bedded Multispecialty Tertiary care Teaching Hospital. Result: In the study population of 133 patients male children were found to be more (58.6 %) than the female children (41.4%) Most of the bronchodilators were prescribed for infants (48.1%). Of the 133 pediatric patients, the major prescription was for SABA (99.2%). Of which the major prescription was for salbutamol (63.2%). Most of the Children with asthma were prescribed with combination therapy of salbutamol and ipratropium (81.3%). In WALRI, patients were prescribed with salbutamol (40.4%) and in acute...
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Posted by admin on Oct 1, 2012 in |
In the present study, natural gums (Hibiscus rosa – sinensis mucilage and Modified gum karaya) was investigated as superdisintegrants for use in fast dissolving tablet formulations containing amlodipine besylate. Fast dissolving tablets of amlodipine besylate was formulated using different concentrations (2, 4, 6, 8, 10) of natural superdisintegrant viz; Hibiscus Rosa – sinensis mucilage and modified gum karaya. Prepared tablets were evaluated for thickness, hardness, friability, uniformity of weight, disintegration time, wetting time and dissolution study. The formulated tablets had good appearance and better drug release properties. The best formulation of Hibiscus rosa – sinensis mucilage (FHR5) and modified gum karaya (FMGK5) shows shorter disintegration time and shows 100% release is selected as optimized formulation. Hence, the present study revealed that this natural superdisintegrants (Hibiscus rosa – sinensis mucilage and modified gum karaya) showed better disintegrating property than the most widely used synthetic superdisintegrants. Studies showed that naturally obtained polymers are more beneficial without any side effects. Optimized formulation was subjected to stability studies as per ICH guidelines and...
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Posted by admin on Oct 1, 2012 in |
Oligohydramnios means the fetus is in a compromised condition. Ante partum amniotic fluid index (A.F.I.) assessment is one of the reliable, good predictor and standard technique for assessment of fetal well-being in antenatal period. In the present study 25 cases of Oligohydramnios in the third trimester were given intravenous amino acid in 1000cc of 10% fructodex drip on 1st day and the amino acid infusion drip in 500 ml of 10% fructodex daily till 6 days. After that biweekly till patient deliver or till term. There were 4 cases of severe Oligohydramnios and 21 cases of moderate Oligohydramnios at the time of their first visit. After amino acid infusion therapy, on repeat ultrasonography, 9 (36%) cases patients with moderate Oligohydramnios had improved amniotic fluid index (AFI) to normal whereas two patients with severe Oligohydramnios had improved A.F.I. to moderate Oligohydramnios and remaining 12 and two patients of moderate and severe Oligohydramnios group patients did not show any changes in A.F.I. Maximum cases delivered...
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Posted by admin on Oct 1, 2012 in |
Vitamin B12 plays an important role in building of genetic material, in development of normal red blood cells and in maintenance of nervous system. Major deficiency symptoms of Vitamin B12 include anemia and neurological disorders. The daily recommended intake of vitamin B12 for an adult is 1.5μg a day. Eating a diet containing required amount of vitamin B12 is the best way to treat the conditions associated with its low level. Vitamin B12 found only in animal based foods such as meats, liver, kidney, fish, eggs, milk and milk products, oysters and shellfish. Hence, vegetarians are more likely to have low level of Vitamin...
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