Posted by admin on Oct 1, 2012 in |
Diabetes mellitus is a lifestyle disorder that is rapidly becoming a major threat to populations all over the globe. Over the past 30 years, the status of diabetes has changed from being considered as a mild lifestyle disorder of the elderly to one of the major causes of morbidity and mortality, affecting people of all ages. India is slated to be the diabetic capital of the world, with 50.8 million diabetics. There seems to be a renewed interest in herbal medicines across the world today and plants are a powerhouse of sources for antidiabetic principles. Hence, a review on the antidiabetic plants has been done and the plants with antidiabetic principles isolated have been tabulated. Electronic searches were conducted in numerous databases and relevant journals. Sources also included various books and newspaper articles. Hand searches were also carried out in additional journals and secondary references. Researchers in the field of Ayurveda, Siddha, Unani and Homeopathy were consulted for access to ongoing research and various references. Molecular docking studies were...
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Posted by admin on Oct 1, 2012 in |
The simple, accurate and precise HPTLC method was developed for quantification of curcumin content in dietary supplement formulation. In this method, individual curcuminoids (curcumin, demethoxy curcumin and bisdemethoxy curcumin) with piperine were resolved using mobile phase n-hexane: ethyl acetate: methanol: formic acid (8: 2: 1: 2-3 drops v/v) on a plate precoated with silica gel 60 F254 and quantified densitometrically in absorbance mode at 421 nm. The Rf value of curcumin was found to be 0.29. Linearity for curcumin was established between concentration range of 100-180 ng/spot with correlation coefficient of 0.999. The method was further validated as per ICH guidelines. The LOD and LOQ values for curcumin were found to be 27.3 ng and 82.7 ng respectively. The results of percent recovery and repeatability studies with standard deviation (≤2%), concluded that the developed method was accurate and precise and can be used for routine analysis of curcumin in dietary supplement...
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Posted by admin on Oct 1, 2012 in |
In the present investigation, fast dissolving tablets of Carvedilol were formulated by using various natural superdisintegrant like Plantago ovata, Lepidium sativum, Fenugreek and Guar gum. A Direct compression method was used to prepare fast dissolving tablets containing Carvedilol as a model drug using natural superdisintegrants. Prepared formulations were evaluated for Precompression parameters such as micromeritic properties like angle of repose, %compressibility and Hausner’s ratio. Tablets were also subjected to Postcompression analysis for the parameters such as weight variation, hardness, and friability, in vitro disintegration time, wetting time, drug content and in vitro dissolution study. The results concluded that amongst all formulations, the formulation prepared with mucilage of Plantago ovata showed better disintegrating property as well as the release profile than the other used natural...
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Posted by admin on Oct 1, 2012 in |
The purpose of the study was to design and evaluate fast dissolving carvedilol tablets using β-Cyclodextrin and superdisintegrants adopting sublimation technique. Tablets were prepared by direct compression method. Tablets were evaluated for their physico chemical properties, wetting time, disintegration, in-vitro release and stability studies. SEM analysis was carried out to determine the surface characteristics of solid dispersions. Precompressional studies revealed good micromeritic properties of powder blend for direct compression. The hardness (3.9-4.3 kg/cm2), friability (0.35-0.51), drug content (96.58-99.43 %) and disintegration time (44.05-66.21 sec) of fast dissolving tablets were found uniform and reproducible. Dissolution of tablets was directly proportional to the superdisintegrants concentration. Selected tablet (F1) was found superior than any other formulations with respect to disintegration and dissolution...
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Posted by admin on Oct 1, 2012 in |
The aim of the present study is to formulate and evaluate taste masked Almotriptan orally disintegrating tablet by using different taste masking agents and different superdisintegrants in different ratios, Almotriptan is a triptan class anti-migraine drug with rapid action, highest bioavailability and low side effects compared to other triptan class of drugs used in the treatment of migraine, Thus formulating Almotriptan as an orally disintegrating tablet is extremely advantageous. However due to its bitter taste formulating Almotriptan into an orally disintegrating tablet is a challenge. Two taste masking agents namely Eudragit EPO and Precirol A To5 are used to taste mask the drug. The oral disintegrating tablets of Almotriptan were prepared using different superdisintegrants and the effect of different superdisintegrants at different concentration on in-vitro release was studied. Almotriptan release from ODT was directly proportional to the concentration of the superdisintegrant used. The optimized formulation was found to release the drug in minimum time and is found to be...
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