Posted by admin on Oct 1, 2012 in |
Crinums occupy an important position within plants of family Amaryllidaceae, and many of them have been broadly used in traditional and ethnomedicines throughout the world. Due to their richness in bioactive phytoconstituents, Crinums have been subjected to extensive chemical, cytological and pharmacological investigations that focused chiefly on their alkaloidal content. Continuing our appraisal about the results of phytochemical, biological and toxicological studies on Crinums and after considering lycorine- and crinine-alkaloids as the major classes in its two previous parts; the current part of our review work draws attention to members of the other less common alkaloidal classes as well as the new types that are not common in the...
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Posted by admin on Oct 1, 2012 in |
A simple, precise and accurate UV spectrophotometric method has been developed and validated for the estimation of Telmisartan in bulk and tablet dosage form. The spectra of Telmisartan in 0.1 N NaOH and distilled water (20:80) shows λmax at 234 nm and estimation was carried out by A (1% 1cm) and by comparison with standard. Calibration graph was found to be linear (r2= 0.999) over the concentration range of 2-10 μg/mL. The proposed method was validated for its accuracy, precision, specificity, ruggedness and robustness. The method can be adopted in its routine...
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Posted by admin on Oct 1, 2012 in |
Investigations into the larvicidal potential of crude extracts of ten Nigerian plants were carried out against the fourth instar larvae of Anopheles gambiae mosquito. The phytochemical screening revealed that both anthraquinones and cyanogenic glycosides were absent in all the plants. However, alkaloids, saponins, tannins, cardiac glycosides, terpenes and flavonoids were either present or absent. The larvicidal activity expressed as % LA was concentration and incubation-time dependent. At 5%w/v (12 and 24h), only Carica papaya and Dacryodes edulis demonstrated remarkable larvicidal activity of 40% and 55% and 50% and 70% respectively while the rest were largely inactive. However, at 10%w/v (12 and 24h), seven of the ten plants namely; Antholeisia djalonensis (60% and 80%), Calotropis procera (50% and 70%), Carica papaya (70% and 80%), Cyathula prostrata (37% and 67%), Dacryodes edulis (90% and 100%), Pycanthus angolensis (45% and 50%) and Viscum album (33% and 73%) gave comparably stronger activities especially after 24h incubation time. This study indicates a potential use of these plants in the control of vector mosquitoes which...
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Posted by admin on Oct 1, 2012 in |
In the past three decades, monoclonal antibodies have become increasingly important class of disease modifying drugs for numerous indications including cancer, inflammatory diseases, and viral infections. Antibody therapy can be used in a variety of ways either alone or combination with cytotoxic compounds. Molecular antibody engineering technologies coupled with advances allow the generation of better antibodies with fully human sequence and optimized function thereby increases the antibody efficacy. Recombinant antibodies and its fragments have been fused to radioisotopes, drugs, toxins, enzymes and antibody-directed pre-targeting followed by prodrug activation (ADEPT) has an alternative strategies for promising therapy of cancer. Various monoclonal antibodies (mabs) have been developed and approved as immunotherapeutic agents. This review briefly describes new development of antibodies and immunoconjugates for broader...
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Posted by admin on Oct 1, 2012 in |
Glossocardia bosvallia DC.1-3 belongs to family Composite which is commonly known as “Patthar-suva or seri” in Hindi. It is found almost throughout in India and Deccan Peninsula. It is a small annual herb, 10-20 cm tall. The tribal inhabitants of western Maharashtra use a decoction of the plant as febrifuge. It has a bitter taste and fennel like odor. Besides serving as a medicinal plant Pithari plant is also used in culinary purposes. In the present paper, we report the isolation and structural elucidation of a new allelochemical 5,6,7,4′, tetrahydroxy 3-methoxy flavone -7-O-b-D xylopyranosyl (1→4)-O-b-D- glucopyranoside (A) which showed antiviral activity , alongwith two known compounds 6, 4΄-dimethoxy-5, 7-dihydroxy-flavone (B) and Isoorientin (C) from methanolic extract of the stems of this...
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