Posted by admin on Oct 1, 2012 in |
A simple, selective, precise and reliable HPTLC method of analysis has been developed and validated for estimation of 6-gingerol in extracts of dried rhizomes of Zingiber officinale and marketed formulations containing Ginger. The method employed TLC aluminium plates precoated with silica gel 60F 254 as stationary phase. The solvent system consisting of n-hexane:ether (40:60v/v). Densitometric analysis was carried out in absorbance mode at 280nm. The method was validated in terms of linearity, precision and accuracy. The LOD and LOQ were 60 and 100ng/spot respectively for 6-gingerol. The average percentage recovery of 6-gingerol was found to be 99.93%. The developed method can be successfully used for identification and quantification of 6-gingerol in extracts and formulations. The method is also suitable for rapid and simple authentication and comparison of differences among samples with identical plant resources but different geographic...
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Posted by admin on Oct 1, 2012 in |
Vaccine development has continuously shifted away from live attenuated or inactivated whole organisms. Although this approach having good efficacy but for improvement on comparison of risk/benefit ratio which needs improvement due to their highly complex compositions which result in safety concerns. As a consequence, a number of indications remained unadressed. The next generation vaccines represented as subunit vaccines, whereby the only pathogens fragments used which are relevant in inducing protective immunity. For the successful subunit vaccination two major key requirements are safe carrier and adjuvant system, since the small, isolated pathogen fragments themselves are generally weak immunogens. Pevion’s virus-like particle (VLP) vaccine technology, called virosomes, and their design is specifically for the development of safe and effective subunit vaccines. Virosomes based vaccination has already been approved in more than 40 countries, including for elderly and infants. It is successful in solid regulatory & safety track record as well as the feasibility of production upscaling. The outstanding profile with combined efficacy and safety of virosomes-based vaccines are known for its...
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Posted by admin on Oct 1, 2012 in |
Salbutamol is a potent anti-asthmatic agent, is a short-acting β2-adrenergic receptor agonist act. In the present study, an attempt has been made to prepare fast dissolving tablets of Salbutamol in the oral cavity with enhanced dissolution rate and to achieve better patient compliance. The tablets were prepared with four superdisintegrants e.g., Sodium starch glycolate, Cross-povidone, Cross-carmellose sodium, Pregelatinized starch by direct compression method. The pre-compression parameters of mixed blend were examined for angle of repose, bulk density, tapped density, Compressibility index and Hausner’s ratio. The tablets were evaluated for hardness, friability, weight variation, disintegration time, dissolution rate, content uniformity and drug content. It was concluded that the fast dissolving tablets with proper hardness, rapidly disintegrate with enhanced dissolution can be made using selected superdisintegrants. Among all formulations, batch D4 was considered as best since it showed enhanced dissolution, which leads to improved bioavailability, improved effectiveness and hence better patient...
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Posted by admin on Oct 1, 2012 in |
Cancer is uncontrolled growth of abnormal cells in the body. The cells causing cancer are called malignant cells. There are so many means by which one can treat the cancer such as chemotherapy, radiation treatment, surgery, etc. With all these treatments there are some side effects as loss of hairs, living cells may get killed, for surgery skilled persons are required and chances of reoccurrences are high. As per those side effects there is less popularity of such drugs. To overcome these problems and side effects liposomal treatment is useful. Liposomal drugs have high encapsulation capacity, hence shows a significant anticancer activity with decreased toxicity preferentially cadiotoxicity. These liposomal treatments have great prolonged circulation as in daunorubicin and pegylated liposomal doxorubicin. This liposomal drug delivery also developed for delivery of various drugs. Further generation of drug delivery systems will include true molecular targeting, immunoliposomes and other ligand directed constructs that represent emphasize on biological components capable of tumor recognition with delivery...
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Posted by admin on Oct 1, 2012 in |
In the recent years, the use of herbal products has been increasing in developing countries. Psidium guajava Linn. (Guava) family Myrtaceae is an important dietary plant used traditionally for medicinal purpose around the world. The fruit part of the guava is used because of its food and nutritional value but other part of the guava plant are used in the traditional system due to their medicinal properties. Since each part of the guava tree possess the economic value. The pharmacological and medicinal use have demonstrated the ability of this plant to exhibit antioxidant, hepatoprotective, antiallergic, antimicrobial, anticancer, cardioprotective, antidiabetic, ant cough, antidote properties. This review delineate with intervention of Psidium guajava in the management of various...
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