Posted by admin on Nov 30, 2016 in |
Aim: To study the relationship between serum Vitamin D levels and insulin resistance in obese and non obese adolescents. Introduction: Vitamin D deficiency in obese adolescent is strongly associated with increased risk for diabetes, hyper tension and metabolic syndrome. Vitamin D insufficiency is a risk factor for developing impaired glucose in childhood obesity and is associated with insulin resistance in obese adolescents. In our study, we examined the relationship between Vitamin D and insulin resistance in obese adolescents. Materials and Methods: The study group included 50 obese adolescent aged (17-19 years) and compared with 50 age and gender matched healthy controls. Anthropometric data were collected and fasting plasma glucose was estimated by (GOD-POD) method, serum Insulin was estimated by (FEIA) method and insulin resistance was calculated by using (HOMA-IR) and serum Vitamin D was measured by using ELISA method. Results: The Vitamin D levels in obese adolescents is slightly lower than the controls. The insulin levels in obese adolescents is slightly higher than controls. Insulin resistance was significantly higher...
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Posted by admin on Nov 30, 2016 in |
Excipients are important partner in formulation that decide dosage form as well as Pharmacokinetics and pharmacodynamics of medicament. In contemporary era, excipients are used from synthetic resources, causes unwanted effect in pharmaceutics and therapeutics. So industries are looking towards natural resources as it delivers safe, biodegradable, cost effective, biocompatible and inert excipient to pharmaceutical industries. Leading organizations like WHO (World Health Organization), ICH (International conference on harmonization), IPEC (International Pharmaceutical Excipient Council) are working together to sort out the complication arises due to synthetic excipient and thus they are showing their faith inside traditional wisdom. In Indian subcontinent, Ayurveda is known medical sciences since 1000 BC and its existence till 21st century create a charm in contemporary scholar with a hope-light that Ayurvedic pharmaceutical wisdom shows a path for unique management of natural excipients. Interestingly, excipients in Ayurveda not only as inert supplements but also take part in pharmacological action. Here author investigated the concept of use, related pharmacokinetics and pharmacodynamics of natural nurture in Ayurvedic dosage form and...
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Posted by admin on Nov 30, 2016 in |
Rosuvastatin is a Dyslipidaemic agent, which acts by inhibiting HMG-CoA reductase enzyme and used in the treatment of hyperlipidemia. But Rosuvastatin calcium (RST) exhibit unsatisfactory dissolution profiles, problems of absorption and poor bioavailability. Thus objective of the study is to increase the solubility and dissolution rate of Rosuvastatin calcium (RST), a poorly water-soluble 3-hydroxy 3-methyl glutaryl CoA (HMG-CoA) Reductase inhibitor through inclusion Complexation with β-cyclodextrin (β-CD). Therefore the present investigation was to design a formulation of orally disintegrating tablets of Rosuvastatin. Orally disintegrating tablets of Rosuvastatin were formulated by superdisintegrants addition method by direct compression technique. Formulas prepared by direct compression showed good results, the prepared inclusion complex with β-CD by kneading method exhibited greatest enhancement in solubility and fastest dissolution (99.363 % RST release in 45 min, 102.22 % RST release in 50 min.) of RST. The inclusion complex contains RST: β-CD (1:1) was formulated into tablets using super disintegrants like sodium starch glycolate, crosspovidone and crosscarmellose. The prepared tablet were evaluated for various post compression parameters like...
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Posted by admin on Nov 30, 2016 in |
Aim: The aim of this review is to provide a detailed documentation and main features such as prevalance, manifestations and management regarding Kawasaki syndrome. Background: Kawasaki Syndrome was first described by Dr Tomisaku Kawasaki in Japan in 1967, since then prevalence of Kawasaki syndrome is increasing in all countries as per the reports in journals. This is more prevalent in Asian pacific regions. Kawasaki Syndrome is the most common cause of acquired heart disease in the U.S. and Japan with a high endemic rate of 150 per 100,000 in children less than 5 years. Materials and methods: This is a review based article, thus information regarding the topic was collected from different journals like European journal of paediatrics, Indian paediatrics , AHA scientific council etc. Reason: The purpose of this review is to put forward a well explained article about Kawasaki...
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Posted by admin on Nov 30, 2016 in |
Objective: The aim of the present study was to evaluate the clinical and radiographic aspects of pulpal and periradicular tissue for patient undergoes endodontic treatment. Patient and method: The present study was limited to patients who treated endodontically by postgraduate students of Conservative Department, School of Dentistry/Faculty of Medical Sciences between January 2014 to February 2015. A total number of 174 case sheets of patients age ranged from 16 years to 53 years with the mean age being 31.1 years and (92) male and (82) female. The data were categorized according to two parameters, clinical and radiographical evaluation of pulpal and periradicular tissue. Results: Out of the 174 patients who were included in the study, symptomatic irreversible pulpitis (44.25%) was the most common clinical diagnostic disease of pulpal tissue and (45.97%) of cases undergo root canal therapy had normal periradicular tissue. Regarding radiographic assessment of pulpal and periradicular tissue, all criteria (alveolar bone, lamina dura, roots, pulp chamber and pulpal canal) are within the normal limit. Conclusion: Symptomatic irreversible...
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