Posted by admin on Nov 30, 2016 in |
In present investigation of some ethyl1-((5-amino-1, 3, 4-thiadiazol-2-yl) methyl) – 5 – ethyl-2, 6-dimethyl – 4 – phenyl-1, 4-dihydro pyridine-3-carboxylate are designed and docked active site of cavity 1# of open channel voltage gated calcium channel protein (3DVE). The compounds evaluated in silico (docking) to distinguish their hypothetical binding mode using the X-ray crystal structure of Ca2+/CAM-CaV2.2 IQ domain complex 3DVE obtained from protein data bank as target protein Respectively. In this docking studies carried out the comparative docking experiments of designed compounds with known calcium blockers Ethosuximide, gabapentine with dock score calculated -4.9318,-4.6489 respectively. Obtained results were evaluated in terms of dock score into the active site of receptor. One of the conformers of compound Cl 123(C1)and AN 123 (C15),CH=CH 123 (C6),Fur 123 (C9) found to have lowest dock scores-3.2496 and -3.1749 , -2.8439, – 2.6359 respectively and said to have more affinity for active site of Ca2+/CAM-CaV2.2 IQ domain complex receptor than other molecules. More the negative value of the energy of binding the better is affinity...
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Posted by admin on Nov 30, 2016 in |
Synthesis of 6-Methyl-2, 4-dihydro-3H-pyrazol-3-one- 4- (4-substituted) Benzylpiperazine derivatives IVP a-e was carried out by bromination of Ethyl aceto acetate (I) with KBr. The reaction was carried out in the presence of Hydrochloric acid and tolune to produce Bromo-ethyl aceto acetate (II), it is further condensed with substituted Benzylpiperazines in presence of ethanol to obtain condensed compound (III). This upon cyclization with excess of hydrazine hydrate will produce title compounds. All the title compounds IVP a-e were screened for possible antibacterial activity against P. Vulgaris, S. Aureas, E. Coli, B. Subtillus and antifungal activity against Altenaria, Culvalaria, C. Albicans and A. Niger. Among the compounds synthesized IVPb and IVPc demonstrated good antibacterial activity, IVb, IVc, and IVe showed good antifungal activity. The activities of the synthesized compounds are compared with the standard and other test compounds. The structures of synthesized compounds were established by elemental analysis, IR, H NMR and Mass spectral...
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Posted by admin on Nov 30, 2016 in |
Aim: The objective of this survey was to assess the awareness pattern of analgesic administration and the various factors impacting the prescription of analgesics. Materials and methods: Pretested interviewer administered questionnaire was distributed to 100 study subjects consisting of post graduates and dental practitioners in Chennai. The questionnaire was designed to contain questions regarding the most commonly prescribed analgesic in various dental procedures and the various factors taken into account by the dentist while prescribing these analgesic drugs. The data was analysed using SPSS software. Results: In this study, the most commonly prescribed analgesic was paracetamol (78%). 63 % of the dentists preferred non-opioids, 28% preferred opioids and the remaining 9% prescribed both opioids and non-opioids.87% of the dentists have chosen combinations of analgesics. The most commonly prescribed combination was paracetamol with diclofenac(59%). 83% of the dentists preferred topical analgesics. 94% of the dentists took into account, the medical condition of the patient while prescribing analgesics. Special care for pediatric patients was given by 97% of the dentists. Among...
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Posted by admin on Nov 30, 2016 in |
Salvia L., is one of the largest genera from Lamiaceae (Labiatae) family which comprises 900 species and is widely distributed in various regions of the world like in America, Europe, Asia. In this review article, the triterpenoid constituents were investigated from all of the Salvia plants to date are reported. About 214 triterpenoids of different classes were isolated and characterized from 113 species of salvia genus. So far the Salvia plants were investigated for their diterpenoids, phenolics and monoterpenes (volatile oils), especially for diterpenoids rather than for their triterpenoid constituents. However, during the isolation procedures of Salvia plant extracts, ursolic and oleanolic acids are common triterpenoid with other constituents isolated. Salvia, in Latin named “salvare”, which means “to heal” so by name its medicinal importance was understand, since from ancient times different salvia species were used to cure more than sixty different ailments ranging from aches to epilepsy, and mainly to treat colds, bronchitis, tuberculosis, hemorrhage, and menstrual disorders. Salvia L., is one of the largest genera from Lamiaceae...
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Posted by admin on Nov 30, 2016 in |
This study was designed to determine the extent of photolytic degradation of diazepam tablets, without light-protective packaging, available in the market. The UV spectroscopy method was designed and applied for this purpose. A total of 2160 tablets (each tablet contained 5 mg diazepam) of three different brand formulations A, B and C were chosen randomly. These tablets were then exposed to different indirect and direct lighting conditions i.e. normal room light condition (for 60 days), direct sunlight exposure (6 hours per day for 3 days), 25 Watt incandescent light bulb exposure and 40 Watt incandescent light bulb exposure (6 hours per day for 3 days). Samples from these light exposures were analyzed for potency determination using UV spectrophotometer and compared against the tablets kept in dark place (Control). Tablets of all three formulations showed marked degradation. The overall average degradations were 23.64%±5.53%; 28.36%±4.87%; 19.72%±4.83% and 25.40%±4.17% respectively for normal room light, direct sunlight, 25 Watt and 40 Watt incandescent bulbs whereas tablets kept in dark place showed little or...
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