Posted by admin on Nov 30, 2021 in |
Shyonak is botanically equated to Oroxylum indicum (L.) Kurz. of family Bignoniaceae. It is extensively used in the Indian system of medicine as an important ingredient of ‘Dashmoola and also one of the important constituents of a reputed Ayurvedic formulation ‘Chyavanprash’. The drug consists of root bark of Oroxylum indicum (L.) Kurz. Ayurvedic Pharmacopoeia of India (API) advocates that the stem bark can be used in case of the non-availability of the root bark. The root and stem bark is used for the treatments of diarrhoea, dysentery, erythema, gastralgia, hoarseness, infantile, measles, sore throat, urticaria, snake-bite and scorpion-sting. During the market survey it was found that the stembark of Ailanthus excelsa Roxb. (Family- Simarubaceae) is being sold in the name of Shyonak as an adulterant. Considering these points, an attempt has been made to identify and to establish quality standards for both root bark and stem bark of Shyonaka (Oroxylum indicum (L.) Kurz. along with stem bark of Ailanthus excelsa Roxb. HPTLC fingerprint profiles showed similar and differentiating bands....
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Posted by admin on Nov 30, 2021 in |
Upper respiratory tract infections are the major cause of childhood morbidity leading to limit the day to day activities and school absenteeism. Diseases like tonsillitis, cough, and cold account for the maximum respiratory tract morbidities. Studies document that, in developing countries, on average, every child has five episodes of acute respiratory infections per year accounting for 30%-50% of the total pediatric outpatient visits and 20%-30% of the pediatric admissions. Ayurveda states that in children, the Prana, Dosha, Dhatu, Bala, Ojas are under developed, and therefore, they are the most vulnerable group in terms of illness. Therefore they should be supported externally to potentiate their immune system. Good immunity has a substantial role in sustaining the body and preventing various infections. Although available conventional management provides symptomatic relief, there is no conclusive evidence that they shorten the duration of symptoms. The use of antibiotic is also not empirical. Therefore it is the need of hour to find some alternative to provide relief in symptoms, potentiate the immune system to resist...
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Posted by admin on Nov 30, 2021 in |
Azetidinones (Azetidin-2-ones), more commonly known as β-lactams, are well-known heterocyclic moieties among the medicinal compounds mainly because of their diverse pharmacological activities such as antimicrobial, anti-inflammatory, anticonvulsant, anti-HIV, anti-parkinsonian, antidiabetic and antitubercular activities. Various com-parative studies of current azetidinone derivatives show an alarming increase in the bacterial resistance to the β-lactam nucleus may be due to irrational usage, which unfortunately led to less therapeutic usage. Hence new hybrids of Azetidinones with other drugs containing different heterocyclic rings found to possess broad-spectrum efficacy against various types of bacteria with β-lactamase inhibition to find great scope for future needs. This concept of hybrid molecules of different heterocyclic drugs would be a cost-effective and time-saving experiment in the process of drug discovery and development. In today’s world of diseases and expensive drugs which are not affordable for countries like India, this attempt would be noon. Hence this review is an attempt to focus on the possible hybrid molecules of Azetidinones with other heterocyclic drugs for various...
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Posted by admin on Nov 30, 2021 in |
In an attempt of synthesizing some novel and potent antioxidant activity having compounds, here some novel quinoline derivatives are reported. Initially using Vilsemeir-Hack reagent method 7-methyl or 8-methyl substituted 2-cholro-3-formylquinolines (Ia, b) were prepared. Further 7-methyl or 8-methyl substituted 2-hydroxy quinoline-3-carbaldehyde (IIa, b) were synthesized by the reaction of compound (I) on microwave irradiation with 4M HCl, which on further treatment with different substituted hydrazides yielded the novel Schiff bases of quinoline III (a-f). Purity of the synthesized compounds was determined by TLC and melting point. The structure of all newly synthesized compounds was confirmed by spectral studies such as IR, 1H NMR, 13C NMR, and mass spectroscopy. All the synthesized compounds were screened for in-vitro antioxidant activity by free radical scavenging activity by DPPH assays method and ferric ion reduction method using ascorbic acid as the standard drug. Screening results showed that all compounds are exhibiting moderate to good activity. Especially compounds III b, III d, and III f showed significant antioxidant...
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Posted by admin on Nov 30, 2021 in |
Euphorbia hirta Linn. (Euphorbiaceae), commonly known as ‘Dudhy’ is an annual medicinal herb of Kumaun Himalaya Uttarakhand. It is an invasive plant used in conventional medicine to treat various diseases such as gastrointestinal disorders, respiratory system disorders, and asthma. The present review is designed to compile updated information on E. hirta, including its medicinal uses, phytochemicals, as well as biological activities. Qualitative and quantitative phytochemical studies on E. hirta revealed the presence of various chemical compounds in which flavonoids, terpenoids, and phenols are the major constituents. These monomeric compounds and crude extracts from E. hirta have also been screened for pharmacological activities in-vivo and in-vitro. Different parts of the plant have interesting antimicrobial, antioxidant, antidiabetic, and antitumor properties. Some traditional uses of this plant, such as in gastrointestinal disorders, bronchitis, and asthma, also indicated its high medicinal potentiality. E. hirta has been proved a valuable medicinal plant for the tribal people living in the rural region of Kumaun Himalaya. The crude hydroalcoholic extract of E. hirta has more pharmacological...
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