Posted by admin on Mar 1, 2014 in |
Purpose: To compare the efficacy and toxicity of chronomodulated concomitant chemotherapy using weekly Cisplatin at 0600 hour and 1800 hour along with radical external beam radiotherapy (EBRT) in the management of locally advanced head and neck carcinoma (LAHNC). Material and method: Previously untreated, histopathologically proven 60 patients of LAHNC (stage III-IVB) were taken for definitive treatment by concurrent chemo-radiation. These patients were randomly assigned (by draw of lots) either of two groups; group I, the 0600 hour cisplatin administration and group II, the 1800 hour cisplatin administration group, each in dose of 30 mg/m2. EBRT was given as 66Gy/ 33Fr/ 6.5 weeks on telecobalt machine. Night shift workers were excluded. Response to treatment and toxicity were investigated. Observations were made at the end of treatment and 6 months of follow up. Results: At the end of treatment, complete tumor response (CRT) in group II were better (40.0% versus 26.7%) and complete node response (CRN) were comparable (34.8% versus 34.6%). Acute skin and mucosal reactions (grade 3) were 3.3% versus...
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Posted by admin on Mar 1, 2014 in |
A toxic substance is one which can produce its adverse effects in biological systems by interfering with their structure and function, which may lead to mortality. From the biological point of view, it can be consider that no chemical is either completely safe or harmful .The safe or harmful nature of toxic substance depends on the doses, duration and the time when animal is exposed to the particular toxic substance. Susceptibility to toxicant often depends on developmental stage. There are critical period of development during pre and postnatal time and a particular structure or function will be most sensitive to disturbance during its critical period. Developmental toxicants are agents that cause adverse effects on the development of new progeny. Recently the developmental toxicology has become an increasingly significant area of toxicology and encompasses the study of hazard and risk associated with exposure to toxicants during pre and postnatal development. It has been expanded by the U.S Environmental Protection Agency to include effects on the developmental process in the course...
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Posted by admin on Mar 1, 2014 in |
Cephalexin remain as one of the most versatile class of compounds against microbes and therefore, are useful substructures for further molecular exploration. A novel series of Schiff bases of cephalexin were synthesized. Thus condensation of 5-thia-1-azabicyclo [4.2.0] oct-2-ene-2-carboxylic acid, 7-[(amino phenyl acetyl) amino]-3-methyl-8-oxo, monohydrate with appropriate aldehydes afforded the Schiff bases. The purity of the compounds was determined by TLC. With elemental analysis and spectral data the structure of the synthesized compounds were elucidated. All the synthesized compounds were subjected for the screening of antimicrobial activity against 3 bacteria and two pathogenic fungi. Most of the synthesized compounds were found to possess moderate antibacterial and antifungal...
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Posted by admin on Mar 1, 2014 in |
The chemistry of β-lactams has taken an prestigious place in organic and medicinal chemistry so the review on recent methods in the synthesis of 2-Azetidinone derivatives rendered as a lead molecule for designing potential bioactive agents and it accompanying additional various synthetic information and its orientations would encompass great deal of help to researchers, chemists and pharmacologists to make it the best, most productive, economical and medicinal important compounds which will be expected to show potent pharmacological activities. In future it would be useful to design different new drugs to bring in the market by using rapid, operationally simple, efficient and green procedure. This has led to the discovery of a wide variety of compounds that are of high interest from the point of view antibacterial, anti-inflammatory, antihyperlipidemic, CNS activity, anticancer, antimicrobial, pesticidal, cytotoxic, antidiabetic, antitumor, antifungal, antitubercular...
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Posted by admin on Mar 1, 2014 in |
A fast, sensitive and accurate reverse phase liquid chromatographic method has been developed and validated for the simultaneous determination of Brinzolamide and Timolol maleate from ophthalmic preparation. Chromatographic separation of these two drugs were achieved on Zorbax Eclipse Plus, Agilent Technology (150mm x 4.6mm, 5μm) as stationary phase with a mobile phase comprising of triethylamine phosphate buffer : Acetonitrile : Methanol (70:20:10(v/v) at a flow rate of 1.0ml / min and PDA detection was set at 274 nm. Injection volume was 10 µl. Column oven temperature was maintained at 40°C. The retention time of timolol, and brinzolamide were 4.0 (±0.5) min, and 10.5 (±0.5) min respectively. Theoretical plate for Brinzolamide and Timolol were 5832 and 4876 respectively. The tailing factor was 1.09 and 1.21 for Brinzolamide and Timolol respectively. Resolution between the two compounds was 16.12. The developed method was validated according to the ICH guidelines and the proposed method can be applied for the routine quality control analysis of Brinzolamide and Timolol maleate from combined dosage...
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