Posted by admin on Feb 29, 2024 in |
Diabetes Mellitus is a chronic ailment characterized by clinical manifestations like hyperglycaemia. The development of novel drugs is based on the understand ding of insulin resistance and oxidative damage leading to secondary complications of diabetes such as Retinopathy, Nephropathy etc. In the modern era, there are numerous allopathic drugs available for the treatment of the ailment. Herbs include a variety of chemical components that are responsible for their therapeutic effects, including polyphenols, saponins, terpenoids, alkaloids, sesquiterpenes, and flavonoids. Herbal remedies, which include traditional medicines, have the ability to treat a wide range of disorders. The use of herbs to treat a condition provides extra benefits by targeting the root cause of the disease. They are less expensive, more effective at lower dose frequencies and have less side effects when compared to allopathic medicines. This review includes a wide range of various phytoconstituents derived from different medicinal plants for the treatment of diabetes...
Read More
Posted by admin on Feb 29, 2024 in |
Phytochemicals are intensively addressed for clinical uses, and nanostructured phytochemical delivery vehicles are on the limelight. A viable potential treatment for neurological disorders is resveratrol. In the current investigation, we sought to create a nanoemulsion containing resveratrol utilising the response surface methodology. Using Neem oil, Pluronic-f 68, and Tween 80, the effects of the formulation and probe sonication processing parameters were analysed even during nanoemulsification process. As process factors, the duration of probe sonication has been preferred. The concentrations of oil and surfactant, along with their intensity, were revealed have a significant influence on globule size. The optimum nanoemulsion formulation constituted 2.6442 mg/ml of resveratrol. The responses picked were globule size, PDI, and zeta potential. The optimised RES-nanoemulsion had a globule size of 179 3.4 nm, a PDI of 0.175, a zeta potential of 29.9 2.1 mV, and an entrapment efficiency of RES-NEs of 96.47 2.3%. The in vitro drug release in pH 6.8 phosphate buffer displayed the nanoemulsion formulation’s superiority. The results indicate that resveratrol nanoemulsion can be...
Read More
Posted by admin on Feb 29, 2024 in |
The Siddha medicine system, predominantly practiced in South India, encompasses a diverse range of medicinal formulations. Among them, Pancha Moola Kudineer Chooranam (PMKC) from the Therayar Maha Karisal literature is claimed to be effective against ulcers. Helicobacter pylori, causes gastric and duodenal ulcers through various transmission routes. It colonizes the duodenal epithelial cells, leading to gastritis, gastric atrophy, and potentially gastric carcinoma. This study provided valuable insights on the potential anti-ulcer activity of root extracts of the formulation PMKC, which includes Glycyrrhiza glabra, Chukrasia tabularis, Terminalia chebula, Terminalia bellirica, and Phyllanthus emblica against Helicobacter pylori through molecular docking. Eight bioactive compounds were identified which underwent docking calculations. The results indicated that these phytochemicals interacted with the active amino acid residues of H. pylori urease, suggesting potential inhibitory effects on the enzyme. Among the compounds tested, Glycyrrhizin demonstrated the highest inhibition against H. pylori urease, followed by Gallic acid. Maslinic acid and Chuktabrin showed minimal inhibition. In conclusion, the active components of PMKC exhibited significant binding affinity to H. pylori...
Read More
Posted by admin on Feb 28, 2023 in |
Glutathione peroxidase gene expression profiling has been determined using budding yeast, S. cerevisiae, as a model organism mainly used for extensively reliable microbial studies of various cellular processes evolved in evolutionarily distant species. Roots of five medicinal plants were used: Withania somnifera, Terminalia arjuna, Ranunculus sceleratus, Bacopa monnieri and Acalypha indica. The maceration method exhibited the extraction process, followed by S. cerevisiae culturing at 600nm. Classic Trizol method for RNA extraction of yeast cells. Further, evaluation of the quantity and quality of the isolated RNA before the CDNA synthesis, respectively. Polymerase Chain Reaction was performed using specific conditions, having 60OC as GPx primers annealing temperature. Real-Time Polymerase Chain Reaction of samples was performed where Beta-actin primers as a housekeeping gene. High purity of RNA samples was yielded to be in the range of 1.8-2.0. The size of cDNA PCR products was found to be 118bp. The RT-qPCR results showed high over-expression, i.e., fold change unit of GPx gene in all sample extracts compared to the control yeast. Ethanol and...
Read More
Posted by admin on Feb 28, 2023 in |
Nanoparticles are small particles ranging from 1 to 100 nanometers. The biological production of nanoparticles is cheaper than chemical production. Besides being cheaper, it is eco-friendly as well. This biological procedure is a bottom-up procedure where the extracts of natural products replace the chemical reducing agents. These reducing and stabilizing agents are found in plants and can be used to synthesize nanoparticles. Plants also have growth terminating and capping properties as well. This paper aims to give brief information on different plant sources and synthesis of nanoparticles. The infection caused by multi-drug-resistant bacteria increases the mortality rate. So, the effect of multi-drug-resistant bacteria is gaining much more importance. The nanoparticles synthesized by green sources are non-toxic to the environment and humans. This review focuses on basic knowledge of nanoparticles, their production by green sources, the application against multi-drug-resistant bacteria, and advantages and disadvantages of...
Read More
