Posted by admin on Feb 28, 2021 in |
Macro and microelements are integrally linked to hormones, vitamins, amino acids, and enzymes in the human body. They affect the normal course of physiological processes. Some medicinal plants contain substantial contents of micro-and macro-elements, which makes it possible to use them purposefully for the prevention and treatment of various diseases. The target of the research was samples of G. macrophylla herb harvested and procured in the Republic of Tyva. The aim of this research provided a quantitative determination of the elemental composition in the herb of G. macrophylla Pall. as a possible source of macro and microelements. The determination was carried out with the atomic absorption spectrophotometry technique. As was discovered, Fe, Mn, Zn, Cu, Cr, Se, Mo, B, and Ag are present in the G. macrophylla herb. The maximum admissible contents of heavy metals in the specimen under study did not exceed the limits recommended for the quality assessment of herbal raw...
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Posted by admin on Feb 28, 2021 in |
Hypertension is the most life-threatening disease amongst all lifestyle diseases. So, there is always a need for such a dosage that can release the drug for a long period from a single dose which will reduce the dose burden for the patient. The propranolol HCL is a non-selective beta-adrenergic blocking agent extensively used in various cardiovascular diseases. In the present study hydrogel matrix tablets of anti-hypertensive drug, Propranolol HCL were prepared and evaluated. The HPMC was used as a rate retarding polymer, whereas Talc was used as filler, and magnesium stearate was used as a lubricant. The present study results point out that the rate of propranolol HCL release from HPMC matrices is mainly controlled by the drug: HPMC ratio. When the concentration of HPMC was enhanced, the release of the drug from the matrix tablet was retarded. The prepared hydrogel matrix tablets were evaluated for various parameters like Angle of Repose, Bulk Density, Tapped Density, Carr’s Index, hardness, friability, uniformity of weight, uniformity of drug content, and disintegration...
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Posted by admin on Feb 28, 2021 in |
Objects: In the present study the anti-ulcer activity of Saccharum officinarum fresh juice was investigated in the chemical-induced ulcer. The efficacy of the plant based juice was compared with standard reference anti-ulcer drug Ranitidine. Methods: The fresh juice collected from the plant of S. officinarum. Firstly, washes the sugarcanes well and peel the outer layer of the cane with a big knife. Then cut them into small pieces and squeeze them for extraction. Take out the extract along with them in a big container. And then study with chemical-induced ulcer in healthy rats. Result: The modal of absolute 40% ethanol-induced ulcer, oral administration of fresh juice (20ml/kg/bw) dose showed that reduction in ulcer index, collection of gastric juice, free acidity, total acidity, and also shows the pH of gastric juice and all parameters compared with the control group. It was showing a protection index of 55.99% at the dose of 20ml/kg/bw. Ranitidine as reference standard drug and showing a protection index of 63.32% at the dose of 50mg/kg-bw. Conclusion:...
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Posted by admin on Feb 28, 2021 in |
An in-silico attempt to predict rat oral acute toxicity, hepatotoxicity, immunotoxicity, genetic toxicity endpoints, nuclear receptor (NR) signaling, and stress response (SR) pathways of metabolites of synthetic medicine Ranitidine and flavonoids of Musa sp. The metabolites of common flavonoids and synthetic medicine were taken from literature, and the prediction was done by using ProTox-II webserver. The predictive results for the toxicity of these metabolites, N-nitrosodimethylamine obtained the lower LD50 value (26 mg/kg) as highest toxicity of class II, i.e., prescribed as fatal after swallowing ranged between >5 and ≤50, and rest compounds were class IV and V i.e., harmful or may be harmful if swallowing ranged between >300 and ≤2000 and >2000 and ≤5000. None of these were showed hepatotoxic as well as not cytotoxic and mutagenic active, but few were immunotoxic, and all metabolites of synthetic origin and two phytometabolites viz. quercetin-3-glucuronide and 5-O-methylmyricetin were obtained carcinogenic active. In the case of NR signaling pathways and SR pathways, three compounds were active on different parameters. In conclusion, this...
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Posted by admin on Feb 28, 2021 in |
Spices, nature’s gift to mankind are the reservoir of secondary metabolites – alkaloids, flavonoids, saponins, tannins, glycerides, sulfides, and other oxygen/nitrogen compounds that can effectively treat viral infections, bacterial infections, and respiratory problems. Since ancient days they have been used for its anti-inflammatory, carminative, antioxidant, anti-clotting, anti-microbial, anti-pyretic, and cardiotonic properties. In search of identifying a natural therapy for severe acute respiratory syndrome coronavirus (SARS-CoV) infections, this review investigates the pharmacological nature of some commonly used spices (ajwain, asafoetida, black pepper, cinnamon, clove, coriander, fenugreek, garlic, ginger, long pepper and turmeric) with special reference to the mechanism of vasodilatory property. Among the selected commonly used spices, turmeric and ginger especially have been reported to alter the expression of angiotensin-converting enzyme 2 (ACE2) to exert its vasodilatory property. The study could lead to a novel exploration of vaccines/drugs aided with a detailed investigation of individual bioactive compounds as well as their synergic...
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