Posted by admin on Feb 29, 2020 in |
The article focuses on the prevalence of obesity in India, increasing levels of childhood obesity, and the potential health hazards that result from obesity, thereby suggesting the necessary preventive measures and the prevailing natural and synthetic therapy that can help to cure the disease, thus spreading awareness about its severity and necessity for treatment. Obesity in India has reached epidemic proportions in the 21st century, with morbid obesity affecting 5% of the country’s population. About 3.4 million people die each year due to overweight and obesity. The numbers are only worsening with each passing year. Anti-obesity medication or weight loss drugs are pharmacological agents that reduce or control weight. These drugs alter one of the fundamental processes of the human body, weight regulation, by altering either appetite or absorption of calories. Thus proper preventive measures and medication can help in reducing the extent of the disease...
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Posted by admin on Feb 29, 2020 in |
Silica lipid-hybrid formulations have gained an increased interest in recent times as a means to enhance the solubility as well as dissolution of poorly water-soluble lipophilic drugs. The objective of the present investigation was to design and optimize silica lipid hybrid particles of Canagliflozin to improve its solubility. Canagliflozin is an antidiabetic drug used to improve glycaemic control in people with type 2 diabetes. In this study, we have fabricated a Solid-State Lipid-Based Oral Drug Delivery System as CNZ SLH with liquid lipids like Miglyol 812, Labrasol and Acrysol el 135. Sylloid 244 FP grade highly porous silica was used as adsorbent. The interaction of CNZ-SLH particles was studied using X-ray powder diffraction (PXRD), Differential Scanning Calorimetry (DSC) and FTIR spectroscopy. CNZ-SLH particles prepared with Miglyol and Labrasol enhanced the solubility of CNZ by 19.67 fold. Optimized SLH particles formulated as a tablet shows faster drug release than the marketed formulation of CNZ Invokana. Silica lipid hybrid particles can be a cost-effective method to formulate drugs with poor...
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Posted by admin on Feb 28, 2019 in |
The indigenous and traditional health care system based on the rich diversity of plants associated knowledge serves more than 70% of the Indian population. More than 7500 species of plants have been used in Indian medical traditions and over 2700 documented species of plants are used in classical medical systems of Ayurveda, Unani and Siddha. About 1800 plants are documented in various Ayurvedic tenets, about 400 in Unani and approximately 500 in the Siddha system. What is of more interest in almost every tribe or forest based community is the existence of impressive localized knowledge and practices of plant based ethno-medicine. Western Himalayas are a source of almost fifty percent of medicinal plants used in Ayurvedic, Unani and allopathic systems but there has been little concerned effort towards their indigenous cultivation. Of 2500 such plants grown in wild only 300 species are currently used by 8000 licensed drug manufacturing units. As an integral part of western Himalayas the State of Jammu and Kashmir is known for its beauty and...
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Posted by admin on Feb 28, 2019 in |
In this study, we developed a cheap and precise analytic method to measure Etodolac concentration in bulk and pharmaceutical formula. The modified, updated method depends on the reaction between ferric ion and Etodolac to yield ferrous ion. Then the former ion reacted with potassium ferric cyanide to form colored compound has a maximum absorbance at 700 nm. The method was validated by calculating the precision and accuracy. The method follows Beer-Lamber law so that we used the range between 1-22.5 µg/mL and the correlation coefficient at 0.997. Accuracy and precision of the proposed method were estimated and shown average of recoveries between (96.67-99.0%) with precision represented by RSD % equal to 1.02. We also calculated the detection limit (LOD) and quantitative limit (LOQ), which respectively were 0.6 µg/mL and 1.2 µg/mL. The modified suggested method was used to measure Etodolac in pharmaceutical preparation without drug additives interference and shows a good agreement with the standard method. Therefore, it can be used for routine works for quality control for the...
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Posted by admin on Feb 28, 2019 in |
Background: Diabetic nephropathy (DN) is a primary cause of end-stage renal disease globally. Activation of mTOR and reduced autophagy has been identified as one of the pathogenic pathways. The presently available drugs have been successful in inhibiting the mTOR signaling, but show low oral bioavailability and suboptimal solubility. Rapamycin is a selective inhibitor of mTOR, shown significant protection against DN. However, its continuous use is associated with side effects. Thus, the search for novel drugs is on great demand. In the present study, in-silico approaches have been adopted to identify potential compounds with optimal oral bioavailability and better solubility properties, with no toxic effect. Materials and method: The receptor protein mTOR with PDB ID: 3FAP was retrieved from the RCSB protein data bank. Total 20 compounds were selected from the list of 113, obtained from LC-MS of Lalchandan. Further, in-silico molecular docking calculation was done by using YASARA software. Drug-likeness and molecular property of best-docked compounds were checked by using Lipinski rule of five and Admet SAR server. Result:...
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