Posted by admin on Feb 28, 2019 in |
In recent times, the use of herbal products has increased tremendously in the developing as well as in developed countries. Bacopa monnieri is one of the most important medicinal plant that has been consumed for thousands of year as a memory enhancing, anti-inflammatory, analgesic, antipyretic, sedative and anti-epileptic agent. For many years, a lot of commercial and medicinal researches have been focusing their resources on this plant. The plant has been known to possess various activities such as, anti-bacterial, anti-fungal, anti-cancer, anti-oxidant, anti-inflammatory, anti-hyperglycemic, anti-depressant, anti-epileptic, memory enhancer, anti-ulcer, hepatoprotective, analgesic, anti-diarrheal, anti-hypertensive, anti-toxicity etc. Therefore step should be taken for its sustainable use and conservation. This review describes the phytoconstituents, traditional uses, and pharmacological activities of Bacopa monnieri. In brief, the biotechnological applications such as tissue culture, elicitation, genetic transformation for the advancement of this plant and its active components production have also been...
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Posted by admin on Feb 28, 2019 in |
Childhood is characterized by periods of rapid growth, maturation, and development. There is a change in the magnitude of the dose required during childhood and adolescence. Thus, Paediatric practice requires a range of dosage forms that are acceptable at different ages and abilities and a range of strengths or concentrations allowing administration of the correct age-related dose. Literature shows that a significant percentage of products suitable for children have inadequate dosing information and the products licensed for children, dosage forms are unsuitable for the intended ages. The development of multiple dosage forms for different ages will rarely be commercially viable and liquid formulations, which can be given to a broad age group, present particular pharmaceutical challenges. However, if there is the commercial incentive of a large market for common illness such as pain or vomiting a complete and varied portfolio of products can be made available. Dispersible drug delivery treatment is one of the breakthroughs that modify the conventional dosage forms (swallowing and chewing) for infants and children. In...
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Posted by admin on Feb 28, 2019 in |
Almost 85% of the world population is infected with the Herpes Simplex Virus (HSV). Herpes simplex virus infections have been described in the medical literature for centuries, yet the drugs available nowadays for therapy are largely ineffective and low oral bioavailability plays an important role on the inefficacy of the treatments. Additionally, the details of the inhibition of Herpes virus type 1 are still not fully understood. The present study was undertaken to evaluate the antiviral property of selected phytochemicals from Verbascum phlomoides L. through their interaction with the Herpes simplex virus. Depending on the non-covalent interaction and best docking score it was concluded that these phytochemicals may be useful for treatment against Herpes infection and can act as inhibitors to Herpesviral protein receptor. Also using phytochemicals as a medium of medication may reduce the cost dependent factor and can be widely used as medicinal purposes to treat several chronic and dreadful...
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Posted by admin on Feb 28, 2019 in |
The present study was designed to develop and validate a simple, sensitive, precise and accurate RP-HPLC method for simultaneous estimation of dicyclomine and ethylmorphine in bulk and tablet dosage form. The chromatographic separation was achieved on Discovery C18 column (250 × 4.6 mm, 5 µm) as stationary phase with a mobile phase of water (pH 5.4 adjusted with orthophosphoric acid): acetonitrile (40:60 v/v) at a flow rate of 1 ml/min and PDA detection at 215 nm. The proposed method was validated for system suitability, specificity, linearity, accuracy, precision, LOD, LOQ, and robustness as per ICH guidelines. The retention times of dicyclomine and ethylmorphine were found to be 3.166 ± 0.02 and 4.204 ± 0.19 min respectively. The calibration curves were linear in the concentration range of 50% to 150% of the working concentration (r2=0.999) for both the drugs in a binary mixture. The accuracy was found to be 98.61 % and 99.24 % for dicyclomine and ethylmorphine respectively. The LOD was found to be 0.05 µg/ml, and 0.20 µg/ml...
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Posted by admin on Feb 28, 2019 in |
Diabetes is a noncommunicable chronic metabolic disorder characterized by high blood glucose level in the body. One of the antidiabetic therapeutic strategies is the inhibition of carbohydrate-digesting enzymes such as α-amylase and α-glucosidase. In the present study methanolic extract and its two fractions (Ethyl acetate and n-butanol) of the whole plant of Trichuriella monsoniae were evaluated for their effect on α-amylase and α-glucosidase enzymes by using in-vitro assays. The plant extracts were used at varying concentrations to ensure which concentration of the extract/fractions of the plant causes the most inhibition. Phytochemical analysis of the extract and its fractions indicated the presence of flavonoids, steroids/terpenoids, carbohydrates, saponin, phenolic compounds. While tannins and alkaloids are absent. n-butanol fraction shown the prominent α-amylase and α-glucosidase enzyme inhibitory activities (IC50 4.09 mg/ml and 3.30 mg/ml respectively) than methanolic extract and its ethyl acetate fraction, and it was well comparable with the standard drug acarbose (for α-amylase IC50 3.62 mg/ml and for α-glucosidase IC50 2.19 mg/ml). Further, the Total phenolic and flavonoid contents were...
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