Posted by admin on Feb 28, 2019 in |
Monosodium glutamate (MSG) is a familiar food additive processed to enhance the taste. This work was carried out to investigate the effect of MSG on platelets profile and indices of thrombus formation together with the detection of some plasma inflammatory markers. The study used adult male mice divided into five groups: a control group and four groups treated with different doses of MSG (2, 4, 8 and 16 mg/kg, respectively for 30 days, orally). The mice treated with 8 and 16 mg/kg of MSG resulted in significant high levels of plasma inflammatory markers such as tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and C-reactive protein (CRP). Also, thrombocytosis, significant increase in fibrinogen (FIG) concentration, low values of prothrombin time (PT) and the associated international normalized ratio (INR) compared to the control group. Our study suggests that MSG initiates inflammatory reactions, which may induce thrombocytosis and coagulation complication in mice...
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Posted by admin on Feb 28, 2019 in |
QbD decrees the definition of a goal for the method and accentuates thorough evaluation and scouting of alternative methods systematically to obtain ideal method performance. QbD tools like risk assessment and design of the experiment, empowers better quality to be instilled into the analytical method and facilitate prior understanding and identification of variables affecting the method performance. Analytical quality by design (AQbD) permits the analytical method for movement within a method operable design region. Unlike current methods, analytical method development using AQbD approaches diminishes the number of out of trend results and out of specification results due to the robustness of the method. It is a current inclination among pharmaceutical industry to implement AQbD in method development processes as a part of risk management, pharmaceutical development and pharmaceutical quality systems (ICHQ10). It owes to the lack of explanatory reviews. The objective of this review article is to provide a comprehensive understanding of various aspect of...
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Posted by admin on Feb 28, 2019 in |
The aim of the present study was to explore the effect of aerial parts of Bauhinia tomentosa extract against gentamicin-induced nephrotoxicity. Thirty male Wistar albino rats were divided into five groups of six animals each. Animals served as Group I (normal control 5 ml/kg b.wt, p.o), Group II (toxic control), and Group III and IV (treatment groups 200 and 400 mg/kg b.wt, p.o) and Group V (standard cystone group 5 ml/kg b.wt, i.p). All groups except group I received gentamicin (80 mg/kg b.wt, i.p) for 10 days. On the 11th day, serum profile (creatinine, blood urea nitrogen, uric acid, aspartate aminotransferases, alanine transaminase, and alkaline phosphatase) and lipid peroxidation, glutathione peroxidase, superoxide dismutase, and catalase levels were estimated in the homogenates of the kidney. Results showed that administration of extract significantly minimized elevated serum levels of biomarkers, decreased kidney lipid peroxidation, increased levels of reduced glutathione content, superoxide dismutase and catalase levels in a dose-dependent manner. In conclusion, the study revealed that ethanolic extract of Bauhinia tomentosa has a...
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Posted by admin on Feb 28, 2019 in |
The objective of the present study was to develop mouth dissolving films (MDF) of Losartan potassium for the treatment of hypertension, with fast disintegration, optimum morphological properties, and mechanical strength. Losartan is an anti-hypertensive drug which undergoes extensive first-pass metabolism that results in low bioavailability of the drug. Through buccal route, the drug directly enters blood circulation and hence bioavailability of the drug increases. Hydroxypropylmethyl-cellulose, sodium carboxymethylcellulose, sodium alginate, and gelatin were used as the hydrophilic film-forming polymeric bases and glycerol as plasticizer. Films were prepared by solvent casting technique. Parameters like in-vitro disintegration time, tensile strength, content uniformity, folding endurance, swelling index, and in-vitro drug release were evaluated. 32 factorial design was used to optimize the amounts of the polymer and the plasticizer. In-vitro dissolution studies showed that 99% of Losartan potassium was released within 5 min with an average disintegration time of 38 sec. UV and FTIR spectrophotometry were used to identify drug-excipient interactions. Accelerated stability studies were performed as per ICH guidelines wherein the MDFs were...
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Posted by admin on Feb 28, 2019 in |
Uterine fibroids are the most common genital tract tumor in reproductive age women. The main treatment option for fibroid is surgical intervention. Options for medical therapy are currently limited to preoperative reduction of symptoms related to uterine bleeding and fibroid size. Ayurveda treatment for this condition is widely practiced in Sri Lanka. We aimed to evaluate the efficacy of two Ayurveda treatment regimes in patients with uterine fibroids. The study is designed as a randomized, single blind, three arm clinical study with 30 participants in each arm. Participants diagnosed with uterine fibroids size 2 cm or more and meet the inclusion criteria are enrolled to this study. Arm I and Arm II undergo two Ayurveda treatment regimens and Arm III is the control group. Endpoint will be calculated from baseline in volume of the largest fibroid by two dimension ultrasound scan after 12 weeks of treatment intervention and repeat in four weeks follow up. Clinical improvements and quality of life is assessed by Uterine Fibroid Symptom and Health-Related Quality...
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