Posted by admin on Feb 28, 2025 in |
Medicinal plants have been utilized to treat a wide range of illnesses throughout human history. Plants are able to produce a wide variety of secondary metabolites, which are chemical substances that assist them defend against predators. The plants are significant for their therapeutic significance because of these organic ingredients, which also have various biological actions. Red silk cotton tree, or Bombax ceiba L., is a member of the Bombacaceae family of plants. B. ceiba is a tall tree whose components are used to treat a variety of ailments. These parts include the flower, leaf, gum, fruits, seed, stem bark, roots, heartwood, and thorns. Essential phytoconstituents including lupeol, vanillin, anthocyanins, shamimin, and mangiferin are found in B. ceiba. The herb has been used therapeutically in Ayurvedic, Siddha, and Unani medicine, among other ancient medical systems. This page provides a thorough analysis of B. ceiba’s pharmacological, phytochemical, and therapeutic...
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Posted by admin on Feb 28, 2025 in |
Uraria picta (family Fabaceae) is an important woody medicinal herb. This plant has been used in traditional systems of medicine for the treatment of various diseases. It is also used in an Ayurvedic formulation of “Dashmula”. The utilization of roots by uprooting the entire plant and the problems associated with seed germination threaten this plant in its natural habitat and cause a shortage of root material for Ayurvedic preparation. The present study aimed to assess seed viability and the influence of pre-sowing treatments on seed germination and seedling development of U. picta. The treatments were applied singly and in combination, including acid scarification (H2SO4), hot and rubbing with sandpaper, pre-soaking in gibberellic acid (GA3), and the application of cuttings to the seed coat followed by pre-soaking in distilled water. The significantly highest rate (90%) of seed germination and a higher proportion of strong seedlings were observed in the seeds treated with 95% H2SO4. The protocol developed for seed germination and seedling development can be applied for raising a large...
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Posted by admin on Feb 28, 2025 in |
Background: Plants for remedial applications are well known, realizing the pharmacological potentials of plants through analytical techniques. Asparagus racemosus is a well-known medicinal plant analyzed using biological approach. The present study was carried out to evaluate the antioxidant, ani-inflammatory, antibacterial effects and the possible bioactive compounds present in the chloroform, methanol and aqueous extract of A. racemosus plant. Methods: The whole plant was subjected to serial solvent extraction using chloroform, methanol, and aqueous. Phytochemical screening, total phenolic and total flavonoid contents were determined using standard methods and was followed by GCMS and FTIR for biological activity of compounds. The plant extracts were assessed for antioxidant activity by DPPH and FRAP assays, anti-inflammatory activity by protein denaturation method, and antibacterial activity by agar well diffusion method. Results: The phytochemical tests revealed the presence of phytochemicals like alkaloids, flavonoids, glycosides, triterpenoids, and saponins. The GCMS of whole plant chloroform, methanol and aqueous extract revealed the compounds that are rich in free radical scavenging activity and proven to be the best source...
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Posted by admin on Feb 28, 2025 in |
Today, obesity has become a global pandemic affecting billions of people worldwide. It is associated with increased risks of various diseases, including cardiovascular and musculoskeletal diseases, psychiatric disorders, cancer, and diabetes, making it a significant public health issue. Obesity has also been linked to an elevated risk of metabolic diseases and changes in brain structure and function. The body mass index (BMI) is widely used to determine excessive weight in relation to height and age. However, BMI may not be accurate for everyone, and BMI z-scores are employed when analyzing data on children and adolescents. The accumulation of excess body fat, which contributes to obesity, is attributed to an imbalance between energy intake and expenditure, controlled by the brain’s central nervous system. Disturbances in the brain circuits that regulate energy balance can impact body weight and adiposity, often involving changes in neurotransmission, which may be addressed with CNS-targeting drugs. The pathogenesis of obesity is characterized by a chronic energy imbalance between excessive calorie intake and inadequate calorie expenditure, primarily...
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Posted by admin on Feb 28, 2025 in |
Discovering Novel MAO-B inhibitors is promising therapeutic strategy for Parkinson’s disease. The pharmacological effects of MAO-B inhibitor showed significant neuro-protection and improved motor function and reduced oxidative stress marker. In-silico molecular docking simulation to investigate the interaction between target protein (MAO-B Inhibitors) and revealing promising hits with high binding affinity and favorable interactions. Molecular docking and binding affinity were analyzed between protein MAO-B inhibitor with selected bioactive compounds and Synthetic drugs in order to find the most potential inhibitor against the target. Thus, the objective of this research can provide an insight comparision based prediction towards some bioactive compounds in Genus momordica species (folic acid, momordicin, Balsaminol-A, Karavilagenin-C, Beta carotene) and few synthetic drugs (Opicapone, Apomorphine, Selegiline, Rasagiline, Ladostigil Zonisamide, Safinamide, NSAID, RG-2833 (gene therapy drug) against MOA-B Inhibitors performed using Pubchem, ProteinDataBank, Biovia discovery studio and PyRx. This research focuses on docking between the potential bioactive compounds shows strong affinity towards the targeted MOA-B inhibitor protein to treat parkinson’s diseases compared to synthetic drugs. This study shows the...
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