Posted by admin on Feb 28, 2026 in |
This prospective observational study measures the prevalence of electrolyte disturbances in diabetes mellitus patients with co-morbidities who were under diuretic therapy. Further the levels of serum electrolytes and fasting blood glucose the patients were correlated with each other. Of all the 120 patients, 33.33% (40) were having diabetes with chronic kidney disease, 56.67% (68) were having diabetes with cardiovascular disease, 10% (12) were having diabetes with both comorbidities. Among them, 2.5% (3) were having hyperkalaemia, 14.17% (17) were having hypokalaemia, 10.83% (13) were having hyponatraemia, 5% (6) were having hypercalcaemia, 10% (12) were having hypocalcaemia, 2.5% (3) were having hyperchloraemia, 13.33% (16) were having hypochloraemia and 5.84% (7) were having hypomagnesaemia. 35.83% (43) were having no electrolyte disturbances. In diabetes mellitus patients with chronic kidney disease under furosemide, a negative correlation was observed between serum potassium and fasting blood glucose. A negative correlation was observed between serum potassium and fasting blood glucose. In diabetes mellitus patients with cardiovascular disease, on furosemide, a negative correlation was observed between serum potassium...
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Posted by admin on Feb 28, 2025 in |
Schedule M is considered as an important part in the Drugs and Cosmetics Act 1940, Rules 1945. For making a product with proper quality and effective for the human beings it is necessary to maintain or follow the guidelines of schedule M. Schedule M is considered as the guidelines which talks mostly about Good Manufacturing Practices. Schedule M was first established in the year 2001 and it was divided into Part 1 and Part 2. Then in the year 2018 it was divided into 12 Parts more precisely than first one which was established in the year 2001. Then in the year of 2024 it became more precise, and it was divided into 13 Parts and including the changes introduced in, the revised Schedule M which include introduction of a Pharmaceutical Quality System (PQS), Quality Risk Management (QRM), Product Quality Review (PQR), Qualification and Validation of Equipment, and a Computerized Storage system for all drug products. These revised Schedule M will help in making the product proper and effective...
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Posted by admin on Feb 28, 2025 in |
This study focuses on developing clindamycin phosphate-loaded calcium carbonate nanoparticles to treat osteomyelitis, utilizing the chemical precipitation method. These nanoparticles were optimized for particle size, zeta potential, drug content, and encapsulation efficiency, resulting in seven different formulations (F1-F7), with formulation F5 was identified as the most effective. Particle size ranged from 275.9 nm to 846.5 nm, and a high homogenization speed of 15,000 rpm was crucial in achieving smaller particle sizes conducive to better bone cell attachment. The zeta potential of -18.8 mV suggested good stability and potential for enhanced interaction with osteoblasts. The optimized formulation F5 exhibited high drug loading (87.56 %) and entrapment efficiency (85.36 %), with FESEM analysis confirming their favorable characteristics for drug delivery. The drug release profile followed a sustained pattern, with 69.60 % of the drug released over 8 hours, adhering to the Higuchi model of quasi-Fickian diffusion. The antimicrobial efficiency tests showed that these nanoparticles could maintain similar inhibitory concentrations against S. aureus as the standard clindamycin phosphate solution, indicating effective drug...
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Posted by admin on Feb 28, 2025 in |
Acne vulgaris is a common chronic inflammatory skin disease found predominantly in adolescents in both sexes. The best acne treatment inhibits bacterial growth, encourages the shedding to the skin cells to unclog pores. Treatment for acne includes topical agents and systemic agents. Its quality monitoring becomes essential for assuring quality products for human care. So, for that purpose a detailed study of review was done including reported and validated methods, official monograph methods for estimation of Nadifloxacin and Adapalene. It was found from a literature survey that among all reported evaluation methods the most widely and predominantly followed method is HPLC. Other methods reported were UV, HPTLC. A conclusion was made that there is lack of evaluation analytical methods for simultaneous estimation of Nadifloxacin and Adapalene in combined dosage...
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Posted by admin on Feb 28, 2025 in |
Anethum graveolens (Dill) leaves and seeds of the plant are mainly used for traditional health treatments like diuretics and stomach disorders. Various observations of Anethum graveolens plant oil and other extracts showed antidepressant, analgesic, antiproliferative, antimicrobial, anti-inflammatory, analgesic, antioxidant activity, effects on gastrointestinal system, hyperlipidaemic effects, contraindications and adverse effects, and effects on reproductive system. Further, it is also used to prevent food spoilage or contamination. In the food industry, it is also used for flavoring foods. The important isolated molecules reported are carvone, dihydrocarvone, limonene, cymen, carvacrol, phellandrene, coumarins, flavonoids, phenolic acids, steroids, etc. The various traditional uses of the plant parts are stomachic and diuretic in Ayurvedic...
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