Posted by admin on Mar 31, 2025 in |
The aim of the present work was to develop clindamycin phosphate-loaded nanosuspension lyophilized powder for axillary osmidrosis caused by bacterial activity in apocrine glands. The formulation prepared using the solvent/antisolvent method included Eudragit L100, PVP K30, and Tween 80. Optimization via central-composite design (CCD) yielded formulation with a particle size of 179 nm and viscosity of 1.35 cps. Characterization confirmed favorable sedimentation volume, drug content and zeta potential with SEM revealing a spherical and porous structure. Lyophilization improved stability and permeability, and in-vitro studies demonstrated 24-hour drug release. Antibacterial testing showed good efficacy against Staphylococcus aureus indicating potential of clindamycin nanosuspension as a promising topical delivery system with enhanced...
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Posted by admin on Mar 31, 2025 in |
Recently care regarding functional finishing of medical apparels such as liquid/blood repellent and antimicrobial has increased due to the risk of harmful microbes generation on these fabrics while coming in contact with fluids such as blood, sebum etc. Of the various medical textiles, surgical apparels are important textile products as they protect health care workers from microbial contamination. As consumers have become more aware of hygiene and potentially harmful effects of microbes, the demand for antimicrobial finished clothing is increasing. Different chemicals and heavy metal finished fabrics even though provide good liquid/blood repellent and antimicrobial activity, but these compounds cannot be used for the development of surgical gown due to factors like toxicity and non-biodegradability. Over the last few years, several attempts have been made to replace petroleum products with renewable and biodegradable components. Hence, fabric finished with chitosan (natural polymer)-herbal bionanocomposite are considered significant for fulfilling these objectives. This review discusses different protective textiles prepared with different antimicrobial and liquid/blood repellent finish used in medical textiles. It also...
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Posted by admin on Mar 31, 2025 in |
Onychomycosis is a fungal infection of fingernails and toenails which accounts for majority of all nail disorders caused by Dermatophytes, Candida and Nondermatophytic Molds. Numerous Antifungal formulations are available in the market in the form of cream, ointment, lotion, powder, and solutions which require high concentration of active agents to be incorporated and have short residence time on the nail bed leading to inadequate penetration and lower efficacy. In the current study an effort is given to develop a superior alternative dosage form using essential oil as an antifungal agent. A medicated antifungal nail lacquer containing Tea Tree oil was developed using different penetration enhancers followed by evaluation of critical quality attributes. The formulation containing both Thioglycolic acid and salicylic acid at the concentration of 15% w/v exhibited favorable characteristics including non-volatile content, drug release, drug content, antimicrobial efficacy and permeability. The formulation containing both thioglycolic acid and salicylic acid exhibited prolonged release for around 12 hours with good permeability. Moreover, the nail lacquer forms a stable film immediately...
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Posted by admin on Mar 31, 2025 in |
The investigation of herbal components in topical formulations is a response to the growing desire for natural and effective remedies. The development, modification, and characterization of a topical herbal hydrogel intended for use in dermatological applications are the main objectives of this work. During the formulation procedure, plant extracts of Turmeric, Aloe vera and Marigold were chosen for well-known medicinal properties. Viscosity and spreadability of herbal hydrogel were optimized. Spreadability and viscosity were the response variables that were employed in the design of formulation. The viscosity and spreadability of the optimized formulation were 176000 m Pa. S and 8.25 g.cm/sec respectively. Phytochemical screening confirmed that the active phytoconstituents present in the herbal hydrogel. According to the antioxidant study, the herbal formulation exhibited good radical scavenging activity, reaching up to 78.02%. Attenuated total reflectance infrared (ATR-IR) spectroscopy revealed that there were no major interactions between the excipients and the herbal drugs. The microstructure of formulated herbal hydrogel was observed using field emission scanning electron microscopy (FE-SEM) imaging, which also showed...
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Posted by admin on Mar 31, 2025 in |
Cardiovascular diseases (CVD) are the leading cause of mortality and morbidity globally, with 17.9 million deaths in 2019. In India, the CVD epidemic is characterized by rapid accumulation, early age of disease onset, and high case fatality rates. India experienced a 59% increase in premature mortality from 23.02 million in 1990 to 37. Million in 2010. Despite improvements in diagnosis and treatment, heart disease remains prevalent, with a 50% chance of developing it by age 45. The main causes of CVD are ischemic heart disease and stroke. India’s age-standardized CVD death rate is higher than the global average. Artificial intelligence can enhance the identification and treatment of cardiovascular disease by improving quality control and enhancing medical professionals’ expertise. This technology can be used in standard clinical procedures, including nanotechnology-based interventions, risk factors determination, treatment regimens, and patient tracking for chronic cardiovascular diseases. This article highlights the global and Indian burden of cardiovascular diseases (CVD), with rising mortality and early disease onset. It emphasizes the need for improved diagnosis and...
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