Posted by admin on Mar 31, 2026 in |
Diabetes mellitus (DM) is a chronic and major endocrine disorder caused by an inherited and/or acquired deficiency in the production of insulin by the pancreas, or by the ineffectiveness of the insulin produced. It is a growing health problem in most countries, and its incidence is considered to be high (4%-5%) all over the world. In the present scenario, the demand for herbal products is growing exponentially throughout the world, and major pharmaceutical companies are currently conducting extensive research on plant materials for their potential medicinal value. This study focuses on the in-vitro investigation of the antioxidant and in-vivo antidiabetic activity of the Methanol and aqueous extracts of Saraca asoca (Roxb.). De Wild seeds in healthy adult Wistar albino rats weighing 200-250 g and Swiss albino male mice (25-35 g). Swiss albino mice were made diabetic by a single dose of streptozotocin (150 mg/kg i.p.). Blood glucose levels and body weights of mice were measured using weekly intervals, i.e, day 0, 7, 14, and 21 after daily administration of...
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Posted by admin on Mar 31, 2026 in |
The nephroprotective activity of the methanolic extract of Coccinia grandis (MECG) leaves was evaluated against acetaminophen-induced nephrotoxicity in Wistar albino rats. Wistar albino rats (150–200 g) were divided into six groups, and nephrotoxicity was induced using acetaminophen (750 mg/kg) administered on alternate days for 10 days. MECG was administered at doses of 125, 250, and 500 mg/kg, while N-acetylcysteine (140 mg/kg) served as the reference standard. Biochemical parameters including serum urea, creatinine, uric acid and antioxidant activity were assessed, along with histopathological examination. All treatment groups showed significant improvement in urine volume and body weight compared to the toxic control. The MECG-500 mg/kg group demonstrated the most pronounced effect (p < 0.001), restoring urine volume to approximately 9.70 mL, close to the normal baseline of 10.85 mL, while the reference group reached 10.81 mL. Lower MECG doses produced dose-dependent improvements. Histopathological analysis further confirmed reduced kidney damage in MECG-treated groups. Overall, MECG, particularly at 500 mg/kg, exhibited strong nephroprotective activity against acetaminophen-induced kidney...
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Posted by admin on Mar 31, 2026 in |
Over-the-counter (OTC) topical analgesics are widely available in Australia and can be purchased without a prescription. These products are typically marketed as treatments for arthritic pain or muscle soreness. There is currently no literature examining the active compounds/botanical extracts usually incorporated in these products, especially relating to products which have not been independently assessed for efficacy by the Australian Therapeutic Goods Administration (TGA). This review aims to highlight the active ingredients commonly incorporated in OTC pain products available for purchase in Australia and assess the literature relating to their efficacy and mechanisms of action. Most of the active ingredients in these analgesic formulations are natural products or plant extracts/essential oils. The most cited active ingredient is Arnica montana despite the lack of conclusive evidence that this plant is efficacious in treating pain when administered topically. The mechanisms for pain relief in the products are mainly transient receptor potential channel agonism, or rubefacient/counterirritant effects, with other products exhibiting cyclooxygenase antagonism. The most common ingredients in TGA registered products are the...
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Posted by admin on Mar 31, 2026 in |
Background: Self-medication is the practice of using drugs without the guidance of a trained health care professional. With the increase in antimicrobial resistance among the masses, this study aims to find the prevalence & behavioral pattern of the practice of self-medication among undergraduate medical students. Materials & Methods: A descriptive cross-sectional study was carried out among 427 MBBS students. The questionnaire was distributed among students via a Google link that was created for this purpose. Result: Our study found that the prevalence of self- medication practice was 74.5%, of whom 71.4% practice self-medication rarely, i.e., once or twice in a year. Practice of self-medication was found to be higher among the female (77.6%) students as compared to the male (71.6%) students. Practice of self- medication was found to be higher among hostelites (76%) when compared to the day scholars (69.8%). 84.2% of the 3rd year MBBS students were found to practice self-medication, which was found to be the highest when compared with students belonging to rest of the academic...
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Posted by admin on Mar 31, 2026 in |
The growing interest in herbal medicine highlights the need to explore traditional plant-based therapeutics through modern pharmacognostic approaches. The review focuses on five well-documented polyherbal agents Ponamia pinnata, Azadirachta indica, Ocimum tenuiflorum, Rubia cordifolia and Eclipta alba valued in both ethnomedicine and pharmaceutical research. These plants are rich in phytoconstituents such as flavonoids, terpenoids, alkaloids, saponins and phenolic compounds, contributing to their broad pharmacological profile. Reported activities include antimicrobial, antiviral, anti-inflammatory, antioxidant, anticancer, hepatoprotective and immunomodulatory effects, indicating potential roles in disease management and hygiene applications. Pharmacognostic evaluation supports standardization by revealing key anatomical and phytochemical characteristics. By combining traditional knowledge with scientific validation, these botanicals exemplify models for translational research.Due to their efficacy, safety profile and cultural relevance, these plants are widely used in traditional medicine and are increasingly incorporated into pharmaceutical, nutraceutical and cosmetic preparations. Integrating traditional knowledge with scientific validation underscores the potential of these polyherbal agents in developing effective, natural therapeutic...
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