Posted by admin on Mar 31, 2026 in |
The aim of this article is to provide a comprehensive review of Gelucire as an effective excipient for improving the solubility and bioavailability of poorly water-soluble drugs. Gelucire, a family of lipid-based, amphiphilic excipients, has emerged as a valuable carrier for enhancing the solubility and dissolution of poorly soluble drugs. Gelucire combines hydrophilic polyethylene glycol esters and lipophilic glycerides, enabling self-emulsification, improved wettability, and formation of stable solid dispersions. Different types of Gelucire are used in oral and topical formulations to improve drug release profiles, bioavailability, and stability. This review discusses Gelucire’s chemical nature, hydration behaviour, and applications in solid dispersions for solubility enhancement. There are other various solubility improvement methods like chemical, physical, and advanced techniques with an emphasis on solid dispersions and their preparation, advantages, and challenges. Combining Gelucire with solid dispersion techniques provides a promising approach for improving drug delivery and therapeutic efficacy of poorly soluble...
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Posted by admin on Mar 31, 2026 in |
Background: Medication reconciliation is an essential step in ensuring patient safety, particularly among the elderly, who are more prone to medication-related errors. Discrepancies often occur during transitions of care due to incomplete communication or missing medication details. Clinical pharmacists play a key role in minimizing such errors by carefully reviewing and reconciling medications. Objective: This study aimed to evaluate and improve the medication reconciliation process in geriatric inpatients using the MATCH (Medications at Transitions and Clinical Handoffs) Toolkit and to highlight the contribution of clinical pharmacists in enhancing patient safety. Methodology: A prospective interventional study was conducted at Ganga Medical Centre and Hospital, Coimbatore, from February to July 2024, involving 600 inpatients aged above 50 years. Data were collected using the MATCH Toolkit and the Best Possible Medication History (BPMH). Discrepancies were categorized (A–D) based on their clinical importance and analyzed during admission, consultant review, internal transfer and discharge. Statistical analysis was done using QI Macros software. Results: Among the initial 400 cases, 71.5% showed medication deviations, which reduced...
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Posted by admin on Mar 31, 2026 in |
Breast carcinoma continues to pose significant healthcare challenges globally, contributing substantially to oncological morbidity and mortality rates, thereby highlighting the urgent need for enhanced therapeutic strategies with improved safety profiles. Traditional Siddha medicine offers valuable resources for the development of potential anticancer compounds. Irunelli Karpam, a classical Siddha formulation composed of purified sulfur and Phyllanthus emblica Linn., was evaluated for its cytotoxic activity against the human triple-negative breast cancer cell line (MDA-MB-231) in-vitro. The formulation was tested at concentrations of 12.5–200 µg/mL using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The findings revealed a progressive decline in viability across the tested concentrations, from 94.61% (12.5 µg/mL) to 12.48% (200 µg/mL), yielding a calculated half-maximal inhibitory concentration of 47.17 µg/mL. Microscopic assessment identified the hallmark features of programmed cell death, including cellular contraction, spherical transformation, and loss of substrate adhesion. The current results demonstrate the substantial growth-inhibitory capacity of Irunelli Karpam against MDA-MB-231 cells which make it a complementary therapeutic agent, warranting further mechanistic studies, toxicity profiling, and preclinical...
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Posted by admin on Mar 31, 2026 in |
Process by which your body’s white blood cells and the things they make protect you from injury or infection from outside invaders, is known as inflammation. These days, inflammation is treated mostly with NSAIDs. Medications, raise the risk of blood clots, leading serious cardiovascular problems like heart attacks and strokes. Therefore, the research is currently being done to develop powerful anti-inflammatory medications using natural ingredients. The chemical diversity of natural products makes them an excellent source for creation of new drugs. An essential component for treatment of many inflammatory illnesses is a natural substance derived from medicinal plants. There are many drawbacks to the conventional medicine used to treat inflammation. These consequences necessitate the search for innovative drugs with minimal or nonexistent adverse effects. As per the reported studies numerous phytoconstituents have demonstrated a wide range of pharmacological effects, but these studies are of only scholarly interest. In current review, anti-inflammatory qualities of a few Indian wild herbs are...
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Posted by admin on Mar 31, 2026 in |
Parangi Kashayam is a traditional Siddha decoction used for Perumootu vatham (Osteoarthritis) that lacks established pharmacopoeial standards despite its clinical use. This study aimed to develop comprehensive quality control parameters following PLIM guidelines through physicochemical profiling, chromatographic fingerprinting, and safety validation. Authenticated herbs including Smilax china, Zingiber officinale, and Senna alexandriana were formulated according to Kumbamuni Vatha Nithanam 800. Various physicochemical parameters were determined, and HPTLC fingerprinting was performed using toluene: ethyl acetate: formic acid (5:2:0.1 v/v/v) as the mobile phase with detection at 254 nm, 366 nm, and post-derivatization. Safety profiling included analysis of heavy metals by ICP-MS, pesticides by GC-MS, aflatoxins by HPLC, and microbial contamination testing. Physicochemical analysis revealed moisture content of 9.09±0.24% w/w, total ash of 4.74±0.18% w/w, acid-insoluble ash of 0.10±0.02% w/w, and pH of 5.20±0.03. The water-extractive value (15.37±0.32% w/w) was significantly higher than the alcohol-extractive value (10.50±0.21% w/w). HPTLC analysis generated reproducible fingerprints with 20 distinct spots having Rf values ranging from 0.04 to 0.82. Heavy metals, pesticides, and aflatoxins remained below...
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