Posted by admin on Mar 31, 2019 in |
Stability of pharmaceuticals is defined as the ability to retain the quality, purity, Identity, and safety throughout the shelf life of products. It is of main concern because drug substance and products lose its Potency and quality after the time passes, due to change in environmental conditions such as temperature, light, and humidity. It is essential that quality of drugs should maintain throw out the life cycle of drug products for their safe and effective use. The need for constant monitoring of the drug substance and product for their quality and purity has the origin of the development of various stability testing methods. Stability testing now becomes a regulatory requirement for filing NDA and ANDA to USFDA and various regulatory agencies. Stability indicating methods had originated from advancement in various analytical instrument technologies. Stability indicating methods of drug substance and products have the ability for separation, identification, qualification, and quantification of all impurities associated with drug substance and drug product at any storage Conditions to give the exact concentration...
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Posted by admin on Mar 31, 2019 in |
Traditional medicine is finding more significance and application today, particularly when we are facing difficulty in the management of numerous medical conditions. More effective and palatable drug dosage forms are needed in the modern era. The recent trend in traditional medicine dosage forms is to enhance the solubility, bioavailability, pharmacological activity, stability, reduce the toxicity and increase the compliance, etc. Oral dosage form which can address these factors are granules (effervescent and rapid release granules), tablets (fast dissolving and rapid disintegrating tablet), capsules, suspension, syrups, etc. and topical dosage form includes toothpaste, natural hair dye, face pack, hand wash, liniment spray and roll-on, gel, creams (emulsion), shampoo, etc. Contemporary, traditional pharmacies including several Ayurvedic pharmacies have already implemented these new trends and launched several new dosage forms apart from traditional under cover of conventional knowledge; few of such Unani products have also been launched. There is an immense need to adopt these recent trends in respect of the dosage form in Unani and another Indian traditional medicine pharmacy for...
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Posted by admin on Mar 31, 2019 in |
The objective of the study is to make a pharmacokinetic evaluation of Pioglitazone floating tablets formulated employing HPMC K 15 M in comparison to Pioglitazone pure drug in rabbits. The two products were tested in a crossover RBD in healthy rabbits of either sex (n=6). The plasma concentrations of Pioglitazone were determined by a validated HPLC method. From the time versus plasma concentration data, various pharmacokinetic parameters (Cmax, Tmax, t1/2, AUC, Ka, and MRT) were calculated. Pioglitazone from the floating tablets formulated was absorbed slowly over longer periods in-vivo resulting in the maintenance of plasma concentrations within a narrow range over a longer period. The absorption rate constant (Ka) was decreased from 1.462 h-1 for Pioglitazone pure drug to 0.1598 h-1 with the floating tablets. MRT was increased from 9.82 h for Pioglitazone pure drug to 13.30 h with the floating tablets. There was no increase in the bioavailability of Pioglitazone from the floating tablets...
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Posted by admin on Mar 31, 2019 in |
To develop a standard conventional solid dosage form like tablets it include the operations involving like milling, mixing, granulation, drying and compression which able to result in different qualities of the final products concerning the loading of the drug, the release of the drug, stability of the drug and pharmaceutical dosage form stability. To overcome some challenges of conventional pharmaceutical unit operations, 3DP is gaining more attention in the pharmaceutical formulation in the future. 3DP can successfully overcome the issues relating to the drug delivery of peptides, potent drugs, water-soluble drugs, and the release of multi-drugs, etc. The ideal opportunity of this technology is the preparation of personalized doses to state individual patient needs. This technology can be seen as the future of solid dosage forms produced on demand, with lower in cost and it also helps in minimizing side effects caused by excessive doses. However, some problems that limit the applications of 3DP in the commercial market, such as selections of binders which are suitable and excipients and...
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Posted by admin on Mar 31, 2019 in |
The present study investigated the protective role of methanolic extract from Anethum graveolense L. (AGME) on bile duct ligation (BDL) produce hepatic fibrosis in the rat. BDL rats were divided into four groups, which received orally distilled water or AGME (200 and 400 mg/kg) for continuously 28 days. The BDL induced hepatic fibrosis by anti-fibrotic effect of AGME in the rats determined by serum level of alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TBL), direct bilirubin (DBL), alkaline phosphatase (ALP), creatinine (CRT), glucose (GLU), triglycerides (TGL), cholesterol (CHOL), total protein (TP), albumin (ALB), transforming growth factor beta-1 (TGF-β1) and oxidative parameter like glutathione (GSH), malondialdehyde (MDA), total superoxide dismutase (SOD) and nitric oxide (NO) level. Biochemical estimation was complemented by histopathological measurement of the liver. Phytochemical in AGME were determined by qualitative and high-performance liquid chromatography (HPLC) analysis. All the serological level was elevated on treated with BDL group alone than in the sham control group (P<0.01). Treatment with AGME these elevations was mostly diminished. Also, increase in...
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