Posted by admin on Jun 30, 2023 in |
Background: Children with mild intellectual disabilities demonstrate wide diversity in academic and behavioural performance. They develop adequate social, personal, and communication skills. As adults, they function in a variety of contexts. Persons with moderate intellectual disabilities have limited intellectual abilities, have problems in abstracting and generalizing, and are not ready for much academic work until their early teens. They show rather clear-cut deficits in adaptive behaviour. The children with mild intellectual disabled show underachievement in all academic areas, have difficulty in working with abstract ideas, and have problems generalizingtheir learning to new situations. The study aims to explore the effect of social skills on the problem behaviour and academic performance of children with mild intellectual disability in aninclusive setting. Materials and Methods: 400 Children with intellectual disability and their teachers in the inclusive set-up both in rural and urban areas of Trichy District were chosen for the study. The data was collected through the Social Skills Rating System (SSRS)-Gresham & Elliott, 1990). Obtained data were transcribed and analyzed using Descriptive and Differential...
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Posted by admin on Jun 30, 2022 in |
A series of novel N10 -substituted 2,4-Dimethoxy acridones were synthesized as potent cytotoxic agents. DNA-binding studies of the synthesized compounds were carried out by the HPLC method using Calf thymus DNA (CT – DNA) based on their affinity or intercalation with CT-DNA, measured by binding percentage. The compound 12 bearing planar dimethoxy tricyclic ring linked with butyl pyrazole side chain showed the highest percentage of binding (90.78%) with CT-DNA and showed binding affinity of -6.08 Kcal/mol with the lipophilicity value of 3.33. Compound 8 showed the highest lipophilicity value of 5.09 with a binding affinity of -6.04 Kcal/mol and a percentage of drug binding (80.93%). Compound 5 showed high binding affinity of 7.01 Kcal/mol with percentage of drug binding (66.94%) and lipophilicity value of 3.72. The Binding affinity and percentage of drug binding showed favorable results. The docking outcome was in good agreement with DNA-binding results confirming the DNA binding activity of compounds. The lipophilicity and binding ability of the acridones with CT-DNA showed poor...
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Posted by admin on Jun 30, 2022 in |
Mycosis is an opportunistic infection that attacks patients who are immunocompromised. Our immune system is designed to defend us against fungus and bacteria. The fungus can expand, penetrate and kill tissue because it lacks immunity. It’s everywhere, in soil and air and even in healthy people’s noses and snot, says the researcher. “As we work to defend ourselves from COVID-19 and live with it, another hazard termed Mucormycosis has emerged. Mucormycosis, a fungal infection caused by Mucor with a 50% fatality rate, maybe provoked by the administration of steroids, a life-saving treatment for severe and critically ill Covid-19 patients. Stay safe from Mucormycosis, a fungus that has been discovered in Covid-19...
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Posted by admin on Jun 30, 2022 in |
Chikungunya is a mosquito-borne infection of the genus alphavirus. It is vaccines, medications, and other treatments difficult to produce. The CHIK-Virus is carried thru the mosquito, which functions as a vector for the disease. Vaccines, therefore, provide alternate preventative techniques for the spread of viral infection. Structural proteins of CHIK-Virus with T and B cells had been used for immuno-informatic approach. The identification of epitopes is a critical step in the development of vaccines against infectious illnesses. The author of this research work used scientific forte databases to choose the binding interactions of the epitopes PLVPRNAEL and RNEATDGTL have been created for a vaccine that contained non-toxic, non-allergenic, however tremendously antigenic determined in Asia, Africa, and Central South America. As a result of it’s far a high-quality feel polymer virus. The replication of CHIKV in the host results in genome mutation, making T-cells from CHIKV. Finally, epitopes acknowledged thru molecular docking research can be wont to supply huge spectrum vaccines, which might be powerful in opposition to numerous lines...
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Posted by admin on Jun 30, 2022 in |
Usually, medicine includes the use of herbal medicines, animal parts, and minerals. However, herbal medicines are the most widely used of the three. The general guidelines for policies on Research and Evaluation of Traditional Medicine cover a wide range of issues and are intended to meet the different states in various countries and regions of the world. Orthosiphon stamineus is an herb that is widely grown in tropical areas. It is also known as Orthosiphon aristaeus. The plant can be identified by its white or elaborate colored flowers that resemble cat whiskers. It was found that O. stamineus exhibits diuretic, hypouricemic and renal caring, antioxidant, and anti-inflammatory, hepatoprotective, gastroprotective, anti-hypertensive, anti-diabetic, anti-hyperlipidemia, anti-microbial, and anorexic activities. Liver failure is continually associated with cellular necrosis, increased tissue lipid peroxidation and depletion in the flesh GSH levels. In addition, serum levels of many biochemical markers like SGOT, SGPT, triglycerides, cholesterol, bilirubin, alkaline phosphatase are elevated. Hence in the present study, the best effort is made to evaluate the caring effect of...
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