Posted by admin on Jun 30, 2018 in |
In the present study 10 morpholine mannich base derivatives were synthesized by three component reaction of morpholine, N-phenylacetamide and various substituted benzaldehydes. Progress of the reaction was monitored by thin layer chromatography and the compounds synthesized were characterized by ATR and 1HNMR techniques. Antimicrobial activity of the synthesized compounds was evaluated against gram positive strains Staphylococcus aureus and Bacillus subtilis and gram negative strains Pseudomonas aeruginosa and Escherichia coli by cup plate method. Candida albicans was used for evaluation of antifungal activity. Three dilutions of the test compounds were taken and compared against ciprofloxacin and fluconazole used as standard. The test compounds were more active towards gram positive than gram negative bacteria. Considerable antifungal activity was shown by the...
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Posted by admin on Jun 30, 2018 in |
Background: Cyperus rotundus Linn. is a traditional medicinal plant appearing among Indian, Chinese and Japanese natural drugs, used for the treatment of spasms stomach disorder and also used as anti-inflammatory, antimalarial, hypotensive, antipyretic, anthelmintic, hepatoprotective agent. Rhizomes of C. rotundus have been used in ancient medicine in India for fever, dysentery, pruritis, pain, vomiting and various blood disorders. Objective: To isolate active Phytochemicals from rhizomes of title Plant. Materials and Methods: Petroleum ether extract of rhizomes was chromatograph over silica gel column and eluted with different solvent systems. Characterization of isolated compounds was done on the basis of spectral studies (IR, 1HNMR, 13CNMR, MS). Results: Ellagic acid (I), 6-hydroxy-3, 4-dimethyl coumarin (II), 6-methoxy-7, 8-methylenedioxy coumarin (III) and quercetin (IV) were isolated. Conclusion: Rhizomes of title plant are rich source of natural compounds and these compounds have very useful medicinal activities so present work gives a direction for future investigators to get some medicinally important...
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Posted by admin on Jun 30, 2018 in |
TNF-α plays pivotal role in initiation of inflammation via its interaction with TNFR1 in an O2.- induced oxidative stress dependent manner. The present study investigated whether the anti-oxidant effect of hydroalcoholic extract of Clitoria ternatea (CTE), could facilitate the anti-inflammatory effect of TNFR1 neutralization in context to carrageenan-induced acute inflammation in mice. Sub-plantar injection of λ-carrageenan (0.1% in saline) elicited profound inflammatory reactions in plantar tissue 0-12 hour (h) post carrageenan injection (p.c.i.), as evident from increased PMN infiltration (myeloperoxidase activity), local and systemic release of cytokines and chemokines, free radical generation and oxidative stress in male Swiss albino mice (20 – 22g, 3 – 4 weeks of age). The inflammatory reactions were attenuated from 6 – 12 h pci in CTE (50 mg/kg) and QG (2.5 mg/kg) pre-treated mice, and were potentiated followed by TNFR1 neutralization with anti-TNFR1 antibody (10 μg/mouse) in terms of significant decreases (p < 0.05) in PMN infiltration, pro-inflammatory cytokines and chemokines as well as ROS/RNS generation and oxidative stress in parallel to decreased...
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Posted by admin on Jun 30, 2018 in |
The use of scorpion venom has a very old history in traditional medicine for thousands years ago in China, India and Africa worldwide. The inhibition of cancer progression and induce apoptosis have shown in an increasing number in-vitro and in-vivo studies. We accomplished this systematic review to evaluate the performance of scorpion venom and its components in the growth inhibition of cancer cell lines. To provide a full data for future researches, the in-vitro and in-vivo studies were adopted in this research. The literature search for the published articles from January 1st, 1968 to January 1th, 2018 was done in PubMed, ISI Web of Science, Scopus, and Science Direct. All the articles were independently screened by applying some predefined criteria by two reviewers in three consecutive steps. We identified 53 eligible studies from among 1,209 studies. So far, scorpion venom and its components have been discovered to inhibit the growth of 38 various types of cancer cell lines. This was the first systematic review includes some tables that provided...
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Posted by admin on Jun 30, 2018 in |
Chitin is the second most important natural amino polysaccharide polymer after cellulose in the world. The main sources exploited are marine crustaceans, shrimp, and crab apart from that some other lobstera, insects, sulphur butter and fungi. Chitosan is the most important natural based common cationic polymer got from chitin has gotten developing consideration for the most part due to their bio-degradable, bio-compatible, bio-renewable and non-lethal properties. The deacetylated chitin derivative chitosan is a useful and interesting bioactive polymer; it has a large pharmaceutical application either. It has numerous reactive amino side groups, which offer possibilities of chemical modifications, formation of a large variety of beneficial derivatives. Chitosan has been found to be used as a support material for pharmaceutical application, gene delivery, cell culture, and tissue engineering. This review is based on the various pharmacological activity of chitosan such as wound healing, anti-hypertensive, anti-cancer, blood coagulant, anti-coagulant, anti-ulcer, anti-microbial, anti-viral, hypolipidemic and hypocholesterolemic...
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