Posted by admin on Jul 31, 2016 in |
Cancer is a major health problem; almost thought – out the world. Herbal medicines have a vital role in the prevention and treatment of cancer. The present study, the in vitro anticancer activity of Calophyllum inophyllum ethanolic leaf extract was evaluated in MCF-7 Breast cancer cell lines. Anticancer activity was evaluated with MTT standard colorimetric assay against MCF-7 cells with IC50 value of 120µg/mL. The biologically active metabolites were identified and quantified by a GC-MS method shows presence of 11 different bioactive compounds. The cytotoxic effect was found to be concentration dependent. Increased concentration of the leaf extract showed increased...
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Posted by admin on Jul 31, 2016 in |
Although the antioxidant and thrombolytic potential of the “super fruit” pomegranate has been well established and documented in in vitro models, its efficacy in an animal model has not been recognised. Therefore in the present study, the aril and rind of Punica granatum were scrutinized for their role in clot lysing competence in a thrombus induced rat model. Visual manifestation, coagulation time parameters and the level of the thrombotic factors confirmed the thrombolysis. The extracts were compared with the standard drug streptokinase that was administered in...
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Posted by admin on Jul 31, 2016 in |
Diabetes mellitus is the common metabolic disorder seen in 2.8% of the world’s population. It is expected to cross 5.4% by 21st century. It is one of the causes of death in this 21st century. Since many years, herbal medicines are used as a source of medicine in Ayurveda and also in some traditional systems of medicine. Ayurveda and other traditional systems have textual evidence about the uses of medicinal plants to cure various types of diabetes in human beings. Thousands of plant species has shown the therapeutic efficacy to control diabetes. As the usage of natural medicinal plants can have lesser side effects when compared with the synthetic drugs. This review mainly aims to know about various plant species in India and all around the world that are used in curing Diabetes...
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Posted by admin on Jul 31, 2016 in |
Statins, 3-hydroxymethyl-3-methylglutaryl coenzyme A reductase inhibitors, are considered safe in lowering hyperlipidemia and cardiovascular disease. Statin attempt to reduce cholesterol production in liver in dose dependent manner not only cause the muscle related problem but also leads to other untoward consequence like arthritis, diabetes, neurological disorders which arise as a result of scarcity in cholesterol production. Discontinuation or reduction in the dose of the statin usually leads to resolution of these side effects but the efficacy is questionable. Though the statin had come to market several decades ago, their harmful effects have been well understood very recently only after several randomized trials. The pleiotropic effects of statin have reported many benefits, but lack of randomized clinical trials make it limit to extend its indication beyond lipid lowering effects. There is still a controversy between their benefits and adverse effects of statin. The upcoming research should focus to resolve the above said confliction that could overcome its most adverse events- myopathy. If it so the statin with pleiotropic effect without...
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Posted by admin on Jul 31, 2016 in |
Background: Malaria is a serious parasitic health problem in India. Plasmodium vivax and falciparum pose the greatest public challenge in endemic areas. P. vivax accounts for more than half of all malaria cases. Accurate and prompt diagnosis is not only important to prevent morbidity, but also helps minimizing drug resistance. Aim: To know the profile of malaria parasite in the patients attending UPRIMS&R, a tertiary care center in Western Uttar Pradesh. Methods: A total 26,939 samples were subjected to smear microscopy (thin and thick) or rapid diagnostic tests. Result: 1330 positive malaria cases were detected. Malaria cases were maximum in year 2010. The proportion of P.vivax, P.falciprum and mixed malaria parasites was found 67% (891 out of 1330), 32% (420 out of 1330) and 1% (19 out of 1330) respectively. Conclusion: There is a decline in trend of malaria cases in India. The highest load of malaria cases was found in month September. P. vivax is still a predominant malaria...
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