Posted by admin on Aug 1, 2011 in |
Artemisinin and its derivatives have successfully been used in treatment of falciparum malaria infections in various parts of the world. More importantly, they have proved effective against strains resistant to conventional antimalarials such as chloroquine and mefloquine in those parts of the world where malaria is endemic. Only one clinically relevant artemisinin-resistant human malaria has been reported recently in South East Asia, although there are reports published on development of the rodent malaria parasite strains resistant to the drug earlier. This article reviews the implications of combination therapy on the pharmacokinetics and hence clinical efficacy of Artemisinins using relevant and published papers. It gives detailed account on the general chemistry and mechanism of action of the parent compound Artemisinin before considering its pharmacokinetics. Artemisinin-based combination treatments (ACTs) are now generally accepted as the best treatment options for uncomplicated falciparum malaria. They are rapidly and reliably effective. The article would focus on combination therapy & its implication on the pharmacokinetics & clinical efficacy of artemisinin & its derivatives and also...
Read More
Posted by admin on Aug 1, 2011 in |
The objective of this review is to form a short compilation of phytochemical screening, pharmacological activity and some analytical methods available for Sapindus mukorossi plant. Although the plant is of importance in Ayurvedic system of medicine mainly as cleansing agent, a review article based on the phytochemical and pharmacological screening of Sapindus mukorossi is not so far reported. The main phytoconstituent isolated and identified from different parts of this plant are triterpenoidal saponins of oleanane, dammarane and tirucullane type. The structure and chemical name of the all the types of triterpenoidal saponins reported in Sapindus mukorossi is included in this review. Many research studies have been conducted to prove the plant’s potential as spermicidal, hepatoprotective, anti-inflammatory, anti-protozoal etc. This review focuses on the phytochemistry and pharmacological actions of Sapindus...
Read More
Posted by admin on Aug 1, 2011 in |
Plants and there preparations have been used as medicine since ancient time. The Ayurveda and various ancient Indian literatures have evidence the use of plants for various disorders. Acalypha indica L is an erect annual herb with numerous long branches covered with soft hairs. According to the Siddha text, ‘Pathartha Guna Chinthamani’ (Page no: 179), Acalypha cures diseases of the teeth and gums, burns, toxins of Plant and mixed origin, stomach pain, diseases due to Pitha, bleeding piles, irritations, stabbing pain, wheezing, sinusitis and neutralizes predominance of the Kabha factor. In the traditional medicine the preparations from whole plants have been used to counter various diseases and disorders. The present review is therefore, an effort to give a detailed survey of the literature on its pharamacognosy, phytochemistry, pharmacological and traditional...
Read More
Posted by admin on Aug 1, 2011 in |
Incidence of cancer in northeast is the highest in India. Nutrition intervention plays a vital role in the management of postponement of cancer. Objectives: To find out the prevalence rate of different types of cancer among the selected male tribal population of Shillong and dietary habits of these tribes the present study was carried out. Methods: Three hospitals from the city of Shillong was followed up for a period of three months, a total of 125 male inpatients and outpatients visiting during the period were interviewed with well-structured interview to collect data on background information, disease history, anthropometric measurement, clinical assessment, biochemical assessment, lifestyle or health hazards, dietary hazards and dietary assessment including weighment survey to assess for the nutrient intake of the cancer patients for three consecutive days. The PGSGA scoring was done to find the suitable level of intervention strategies. Nutrition intervention through Macrobiotic Approach was given to the patients and their family members using pamphlets, booklet and an e-content. Results: It was found out during the...
Read More
Posted by admin on Aug 1, 2011 in |
Bindens pilosa L. is a cosmopolitan weed, originally from South America and common in all tropical and subtropical areas of the world. It is a small annual weed occurring all over the country. Roots, leaves and seeds have been reported to possess antibacterial, antidysentric, anti-inflammatory, antimicrobial, and hypotensive activities. Extracts of this plant is used in southern Africa to cure malaria. In tropics also it is used on snakebite and malaria. It is used in traditional medicine as a remedy to treat glandular sclerosis, wounds, colds, flu and urinary tract infections. Leaf extracts in petroleum ether, chloroform, acetone, methanol and distilled water were tested against five bacteria. Maximum zone of inhibition was produced by acetone and petroleum ether extract against Proteus vulgaris, and least activity by methanol and aqueous extract against bacillus...
Read More
