Posted by admin on Aug 1, 2011 in |
Since ancient times, plants have got medicinal importance. Ethno medicinal use of plants is very common in rural parts of India. Various constituents of these plants have shown profound therapeutic and prophylactic activities. The present research work is conducted to investigate invitro antimicrobial activity of various extracts of seeds of plant Cleome viscosa Linn. The petroleum ether, chloroform, ethyl acetate, ethanol & water extract of seeds of plants were screened against eight microbial species. Clinical samples of pus from earache patients were also used. The test materials have shown significant antimicrobial activity. The zones of inhibition are found to be between 10 mm to 17 mm. The minimum inhibitory concentration (MIC) values of extracts are also determined against microorganism which ranges from 0.1 to...
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Posted by admin on Aug 1, 2011 in |
In present study, a successful attempt has been made to develop a simple method for the simultaneous determination of ofloxacin and ornidazole using linear sweep Voltammetry (LSV) technique. Quantification of ofloxacin and ornidazole was done in Britton-Robinson Buffer of pH 5.5 using 0.1M KCl as a supporting electrolyte. Both ofloxacin and ornidazole exhibit reduction cathodic peak in given pH with peak potential at -1.30 V for ofloxacin and -0.42V for ornidazole vs. S.C.E. 0.1N HCl was used as Solvent for the analysis. The method was validated in the terms of its linearity, accuracy, precision, robustness, ruggedness, LOD and LOQ. Proposed method was found to be simple, precise, and accurate and can be successfully applied for routine quality control analysis and simultaneous determination of ofloxacin and ornidazole in combined drug formulations....
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Posted by admin on Aug 1, 2011 in |
Microemulsions are clear, stable, isotropic mixtures of oil, water and surfactant, frequently in combination with a cosurfactant. Microemulsions act as potential drug carrier systems for oral, topical, and parenteral administration. They offer the advantage of spontaneous formation, ease of manufacturing and scale-up, thermodynamic stability, and improved drug solubilization and bioavailability. Preparing a pharmaceutically acceptable dosage form demands a clear understanding of the micro-emulsion structure, phase behavior, factors leading to its thermodynamic stability and the potential uses and limitations of the microemulsion system. Knowledge of the various methods available to thoroughly characterize a microemulsion system is essential. While microemulsion is used in several fields, in this review the pharmaceutical applications are emphasized. Several references are cited, but the list is by no means exhaustive. The review is written so that a newcomer to the field can easily grasp the important facts pertaining to this novel delivery...
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Posted by admin on Aug 1, 2011 in |
The present work was carried out to design the floating drug delivery system to minimize the side effect, improve the prolongation of action, to reduce the frequency of administration. The objective of the present investigation was to develop a bilayer-floating tablet (BFT) and evaluate for domperidone maleate using wet granulation technology. HPMC, K-grade and effervescent sodium bicarbonate formed the floating layer. The release layer contained domperidone and various ratios of polymers such as HPMC-K100M.The floating behavior and in vitro dissolution studies were carried out in a USP paddle apparatus 2 in simulated gastric fluid. Final formulation released approximately 104% drug in 12 h in vitro, while the floating lag time was 4 min and the tablet remained floatable throughout all studies. Statistically significant differences were found among the drug release profile from different formulations Final formulation followed the Higuchi release model and showed no significant change in physical appearance, drug content, floatability or in vitro dissolution pattern after storage at 45°C/75% RH for three months. The release mechanism was...
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Posted by admin on Aug 1, 2011 in |
The quality control of herbal drugs and their extracts is essential when they are used as raw material for the development of herbal medicines. In this work, several techniques (pharmacopoeial and non-pharmacopoeial) were performed, aiming at establishing quality control parameters of the leaves of Heliotropium indicum L. (Boraginaceae), a shrub popularly known as stinker (fedegoso) in Brazilian northern and northeastern regions. The results determined the physicochemical characteristics of the drug and the tincture of the leaves. They also showed that the values obtained are in accordance with the data found in the literature for plant material. Preliminary phytochemical analysis of the leaves demonstrated the presence of phenols, tannins and alkaloids. The chromatographic profile showed the presence of a common substance in the hexanic and alkaloidal...
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