Posted by admin on Jul 31, 2023 in |
Background: Geriatrics refers to the population of 60 years and older. The geriatric population is considered a significant consumer of prescription medications. Polypharmacy is a global phenomenon, and on the elderly population, the impact of polypharmacy is substantial. Aging is a multidimensional process, and it is a growing concern. Multiple comorbidities are one of the reasons for polypharmacy. Comorbidity is associated with more complex clinical management and the increase of drug use, and health care costs. In older adults, Drug-drug interactions have potentially life-threatening consequences. Methods: A prospective observational study was carried out for six months in a private corporate hospital in Secunderabad, Hyderabad. The data on patients aged 65 years and above who are hospitalized with comorbid conditions is collected from case sheets. Data includes socio-demographic details, number of medications, name of medications and comorbidities. Results: A total of 300 patients were included in the study. Polypharmacy was seen in 217 (72%) prescriptions and non-polypharmacy was seen in 83(27%) prescriptions. A total of 168 comorbid conditions were found...
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Posted by admin on Jul 31, 2023 in |
In recent years, the transdermal route has emerged as the most advantageous method for medication administration. It overcame several problems associated with the oral mode of drug administration, including significant issues with previous metabolism. To get around this restriction, transdermic administration systems have been created; however, the medications that can be administered via this route still encounter challenges since some of the drugs’ particles are ineffective at efficiently penetrating the stratum corneum. Our scientists and researchers have created a novel technology called as the extremely deformable vesicle system to meet this difficulty. The medicinal molecule, whether synthetic or natural, is combined with vesicles in this method so that it may be delivered to specific areas of the skin. Transethosomes are a unique promise for improved transdermal medication administration via the skin among transferosomes and ethosomes. Nanotransethosomes’ efficient penetration is facilitated by ethanol, edge activator, and phospholipids. The UDV can be used to administer a variety of medication classes via the transdermal route, including anti-arthritic, antibacterial, anticancer, antiviral and...
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Posted by admin on Jul 31, 2023 in |
The absorption of drugs through the gastrointestinal tract is a highly variable process; prolonging gastric retention of the dosage form extends the time for drug absorption. A novel drug delivery system overcomes the physiological problems of short gastric retention by decreasing fluctuations in blood drug concentration with subsequent reduction in undesirable toxicity and poor efficiency. Various approaches have been introduced to prolong gastric residence time, including floating drug delivery systems (FDDS), swelling and expanding systems, polymeric bio-adhesive systems, high density systems, modified shape systems, etc. Bilayer floating drug delivery systems are the most promising drug delivery system, which exhibits a unique combination of floatation and bilayer, leading to prolongation in residence time in the stomach. Floatation is achieved due to bulk density being less than gastric fluids. So, the system remains buoyant in the stomach for a prolonged period, releasing the drug slowly at the desired rate and thus increasing the bioavailability of narrow absorption window drugs. This review entitles the floating drug delivery system principle and current technology...
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Posted by admin on Jul 31, 2023 in |
Transfersomes, which may penetrate mammalian skin, are notably ultra deformable (ultraflexible) lipid supramolecular aggregates. A type of formulation carrier system called a transfersome can transport medications with both low and high molecular weights transdermally. Transfersomes enter the underlying viable skin in an undamaged state through skin’s stratum corneum pores that are smaller than its size. The major goal of the transferosome in treating the condition psoriasis is drug penetration through the skin. However, the stratum corneum is the most formidable defence against drug penetration via the skin. In order to assist penetrate the stratum corneum barrier, the use of lipid vesicles like transfersomes in delivery systems has attracted increasing interest in recent years. The current study set out to statistically improve the vesicular formulations (Transfersomes) of a model medicine, boswellic acid which is obtained from Boswellia serreta known as for the treatment of...
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Posted by admin on Jul 31, 2023 in |
The Present study was planned to gauge the immune-modulatory activity of the ethanolic extract and the isolated compound Stachydrine from the leaves of Capparis sepiaria L. (Capparidaceae). The study was extended to research the chemical compounds within the EECS (Ethanolic Extract of Capparis sepiaria). The preliminary phytochemical screening revealed that EECS evidenced the presence of varied phytoconstituents like alkaloids, glycosides, reducing sugars, flavonoids, saponins, starch and terpenoids. The alkaloidal compound Stachydrine was isolated and further evaluated by using UV, IR and NMR. Both in-vitro and in-vivo studies were administered to gauge the immunomodulatory effect of ethanolic extract of C. sepairia and the isolated alkaloid Stachydrine using Phagocytosis and Jerne plaque assay. Both ethanolic extract (25.82% for 70mcg/ml) and the isolated compound (21.28% for 25 mcg/ml) showed the enhancement of phagocytic index compared to regulate (18%) also because the number of plaques proportional to the amount antibody-producing lymphocytes within the cell population after the treatment with extract of C. sepiaria (551.25± 4.26 and 620 ± 7.25 for the 100mg/kg and...
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