Posted by admin on Jul 31, 2021 in |
Background: Scorpionism is an endemic and highly prevalent public health predicament causing severe cardio or neurotoxic effect. Ayurveda proposes a range of medicinal preparations (internal & external) in the management of Vrishchika Damsha (Scorpion sting). Among them, Hingwadi and Jeerakadi lepa are topical anti-inflammatory medications, and Bilwadi Gutika is a potent vishahara medicine (Alexeterics). Aims: To evaluate the comparative effect of Hingwadi Lepa against Jeerakadi Lepa with Bilwadi Gutika pana in the management of manda vrishchika damsha (mild scorpion sting). Methods: The present study adopted an open labelled two armed clinical trial of before and after the pilot study. It was conducted at a tertiary Ayurveda center with 30 subjects satisfying inclusion and diagnostic criteria. They were selected by convenience sampling method and divided randomly into two groups. Group I received Hingwadi lepa, and Group II was given Jeerakadi Lepa twice daily & Bilwadi Gutika pana (1gm) t.i.d. was administered orally in both groups for 7 days. Standard scoring of cardinal symptoms was used to measure the efficacy of...
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Posted by admin on Jul 31, 2021 in |
A series of 3,6-bis (3/-substituted propoxy) and 3,6-bis (5/-substituted pentyloxy) xanthone derivatives was synthesized by the condensation of 3,6-bis (3/– bromopropoxy) and 3,6-bis (5/–bromopentyloxy) xanthones with primary or secondary amines. These compounds were characterized by FT-IR, 1H NMR, and Mass spectral data. The anti-inflammatory study of the synthesized compounds was carried out using the carrageenan-induced rat paw edema method on Albino rats of Wistar strains. Thirty minutes after injection of 1% carrageenan solution into the sub plantar surface of the left hind paw, synthesized drugs were orally administered at a dose of 100 &200 mg/kg body weight. The compounds S3, S17, and S20 at a dose of 200 mg/kg body weight showed 63.32%,62.75%, and 60.71% paw edema reduction respectively after 6 hours as compared to standard diclofenac (10mg/kg) body weight which showed 68.27% reduction of paw edema after 6 hours. The molecular docking studies were also carried out in the active site of COX-2 enzymes (PDB ID: 1CX2) using Discovery studio version 2.5. The in-silico ligand binding interactions of...
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Posted by admin on Jul 31, 2021 in |
Cancer initiates from the transformation of normal living cells into malignant cells via a multistage event that usually advances from a pre-cancerous phase to a malignant tumour. Anti-metastatic drugs or anti-neoplastic drugs prevent and regulate the growth of onco cells. Based on the mode of drugs, the universally anticancer drugs market is categorized into cytotoxic, targeted, and hormonal drugs. The targeted drugs class is further divided into monoclonal antibodies, tyrosine kinase inhibitors, and others. The worldwide anticancer drugs market falls into five regions: North America, Europe, Asia Pacific, Latin America, and the Middle East and Africa. Cancer is considered the second largest cause of death globally and is responsible for an estimated 9.6 million deaths in 2018. Globally, about 1 out of 6 deaths is due to cancer. Approximately 72% of deaths from cancer occur in developed and developing countries. Synthetic drugs and other modes of treatment are pre-existing. Chemotherapy treatments have its own limitations due to their toxic effects on non-targeted tissues and it further leads to health...
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Posted by admin on Jul 31, 2021 in |
The current work comprises the assessment of antidiabetic activity of chloroform, ethyl acetate, and ethanol fractions and isolation of some phytoconstituents from chloroform fraction obtained from ethanolic extract of Echinochloa colona. The antidiabetic activity was performed using streptozocin induced diabetic model in male Wistar rats (150-200 g). The best restraint results were for metformin, chloroform, ethyl acetate and ethanol fraction was 5.85 ± 0.004 (90.08%), 6.65 ± 0.004 (67.36%), 6.96 ± 0.003 (60.14%) and 7.05 ± 0.004 (58.01%) respectively, comparing controlled diabetic rats which showed a significant reduction of blood glucose level. On total cholesterol level metformin, chloroform, ethyl acetate and ethanol fraction showed decrease in total cholesterol level by 12.16 ± 0.0044 (56.98%), 13.02 ± 0.004 (53.94%), 14.17 ± 0.004 (49.87%) and 16.37 ± 0.004 (42.24%) respectively. Significantly triglyceride was decreased by 10.39 ± 0.0044 (46.49%), 13.16 ± 0.004 (32.23%), 14.06 ± 0.004 (27.60%) and 14.56 ± 0.004 (42.24%) for metformin, chloroform, ethyl acetate and ethanol fraction respectively. Three important phytoconstituents were isolated from chloroform fraction, and structures...
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Posted by admin on Jul 31, 2021 in |
Previous studies investigated the host-derived salivary matrix metalloproteinases (MMPs) are responsible for dentin caries progression. The utilization of the MMP inhibitors can become a successful strategy to control dentin caries. In this study, we have tested twenty-four different medicinal plant leaf extracts against human salivary MMPs for investigation of inhibitors. Total phenolics were extracted in methanol, and their assessment was performed by Folin-ciocalteau assay. The presence of salivary MMP inhibitors in all plant leaf extracts was tested by using gelatin zymography. S. cumini leaf extract was found to be containing the highest total phenolics content. Leaf extracts of S. cumini, T. catappa and C. fistula exhibited strong inhibitor activity against salivary MMPs. Presence of inhibitor activity was found to be depending on the amount of phenolics concentration in extracts. The inhibition of salivary MMPs due to the binding action of phenolics with salivary proteins was concluded. As per the data of image J gel analysis software, T. catappa leaf exhibited prominent inhibitor activity as compared to other plants. The...
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