Posted by admin on Jul 31, 2021 in |
Andrographolide is a labdane diterpenoid isolated from the leaves and roots of Andrographis paniculata Nees (Acanthaceae). Andrographolide is isolated by various processes and the simple method is the maceration process. It is bitter in taste and used as hepatoprotective, cholinergic, antispasmodic, stomachic, anthelmentic, alterative, blood purifier, and febrifuge. It promotes the secretion of bile in the liver and is used in jaundice, torpid liver, cold and upper respiratory tract infection. It is also used in the treatment of snake bites and is found to be more effective than the anti-snake venom generally used. Hesperidin is a flavanone glycoside isolated from the peels of Citrus sinensis (Rutaceae). Hesperidin plays an important role in plant defense mechanisms. Hesperidin is commonly isolated by two laboratory processes maceration and continuous percolation method. The major pharmacological actions of the hesperidin reported are anti-hyperlipidemic, cardioprotective, antihypertensive, antidiabetic, antioxidant, anti-inflammatory, and antiartherogenic activity. However, what is noteworthy about this paper is highlighting the evidence-based overview on the chemical and physical nature of Andrographolide and Hesperidin along...
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Posted by admin on Jul 31, 2021 in |
The proposed study was to evaluate the in-vitro cytotoxic and antiproliferative activities on prostate cancer cell lines of isocordoin (1) and 2’,4’-dihydroxy-3’-(g,g-dimethylallyl) dihydrochalcone (2), chalcones isolated from roots of Lonchocarpus xuul Lundel, together with four analogues of 1. Isolation of compounds 1 and 2 from L. xuul roots and chemical modification were in accordance with previous works. All compounds were characterized by NMR spectroscopy and mass spectrometry. In-vitro cytotoxic and antiproliferative activities of compounds 1-6 against prostate cancer cell lines PC3, PC3M, DU145, and TRAMPC2, were evaluated using the MTT and sulforhodamine B method, respectively. Additionally, cytotoxic studies with HEK 293 cells were carried out, and a selective index was calculated. From them 2’,4’-dihydroxy-3’-(g,g-dimethylallyl) dihydrochalcone (2), 2´,4´-diacetoxy-3´-(3-methylbut-2-enyl) chalcone (3), 2´-methoxy-3´-(3-methylbut-2-enyl) chalcone (5) together with isocordoin (1) showed the strongest cytotoxic activity on PC3M cell lines in the ranged of 2-3 mg/mL. Isocordoin showed the strongest activity also on TRAMPC2 cell lines (CC50= 1.01 mg/mL). None of the compounds were cytotoxic (CC50 =14 to 667 mg/mL) on HEK293 cell line....
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Posted by admin on Jul 31, 2021 in |
Background: Urinary Tract Infections (UTIs) are one of the most commonly occurring infections in medical practice despite the widespread availability of antibiotics. This study aims to ascertain the prevalence of uropathogens and determine their antibiotic susceptibility or resistance patterns in the Indian population. Methods: A thorough search on the research studies concerning UTIs and their antibiotic susceptibility patterns in India was conducted through electronic databases including Google Scholar, Directory of Open Access Journals, Web of Science, Elsevier, etc. Search results were evaluated for the appropriateness of being included in the study. A total of 12 reports published from different regions of India were involved in the study. Analysis of data was performed using Comprehensive Meta-Analysis (CMA) software. Results: The most commonly isolated uropathogens were observed to be E. coli, and Klebsiella spp., with a prevalence of 49.6% and 12.8%, respectively. The highest mean resistance was found to be towards Ciprofloxacin, followed by Ampicillin. Resistance patterns in E.coli were found to be more towards Ampicillin (74.11%) and followed by Ciprofloxacin...
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Posted by admin on Jul 31, 2021 in |
The present pharmacological examination was purely focused on the assessment of the efficacy of ethanolic extract of C. pedata var. glabra for their protection against Paracetamol overdose-induced hepatotoxicity arbitrate with their phytoconstituents and also observe whether synergistic hepato-protection exists with Silymarin. For animal studies, the Albino rats (150–200 g) were divided into six groups viz., Group I served as control, Group II served as a toxic group, Group III received Silymarin and Group IV, V and VI received plant extracts at the rate of 100, 200 and 400 mg/kg. After group segregation, on 15th day, Paracetamol was administered to groups II, III, IV, V, and VI. The results indicate that compared with Group II the Group I are significant at p<0.05. However, Group III, IV, V, VI are significant at p<0.05 when compared with Group II. Pretreatment with ethanolic extract-treated groups significantly prevented the physical, biochemical, histological, and functional changes induced by Paracetamol in the liver. The extract showed significant hepatoprotective effects as evidenced by decreased serum enzyme activities...
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Posted by admin on Jul 31, 2021 in |
Enzymatic browning is a process that occurs in fruits and vegetables by the enzyme polyphenol oxidase, which results in brown pigments reduce shelf life which indirectly causes huge domestic loss to the farmers during the post-harvesting process. In this context, the present study was carried out to preserve and increase the shelf life of Brinjal vegetables from enzymatic browning using ascorbic acid. The seeds of Brinjal hybrid and wild were treated with (0.5-2%) concentrations of Ascorbic acid; after 21 days of treatment, the plant material was extracted, Partially purified, and analyzed for enzyme activity. The polyphenol oxidase was extracted and determined for enzyme activity, phenol content, protein concentration as well as functional group determination using FTIR analysis. The polyphenol oxidase activity decreased with an increase in ascorbic acid concentration. The study revealed that the protein content in the Brinjal hybrid variety had a maximum of 221 µg/ml, whereas the wild brinjal variety possesses 180 µg /ml. The phenolic content of the hybrid Brinjal variety was found to be 67...
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