Posted by admin on Jul 31, 2021 in |
The study was carried out to determine the chemical, functional, and structural properties of starch that was isolated by various methods from pearl millet (Pennisetum Typhoidium). Isolation methods of starch with different chemicals influenced starch properties. Pearl millet starch was isolated by Sodium azide (alkaline) (T1), Sodium metabisulfite & lactic acid (T2) (neutral), and Mercuric chloride (acidic) (T3). Chemical and functional properties were observed. T1 yielded a higher amount of starch (56.3 /100g) (db) compared to T2 and T3. Proximate analyses of starch showed that the protein content was 0.21 – 0.31%, apparent amylose was 19.42 – 21.60%; however, similar values were observed in fat (0.01%) and ash (0.05%). The swelling power and solubility of the isolated starches differed significantly. The crystalline degree of pearl millet starch of T1 T2 T3 was 37.91, 29.22, and 19.92%, respectively. The result showed that isolation methods brought changes in yield, chemical, and functional properties of pearl millet starch. Starch isolated with alkaline had a higher amount of yield, apparent amylose, and total...
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Posted by admin on Jul 31, 2021 in |
In global debates, traditional herbal medicines are getting a lot of attention, especially in the treatment of Epilepsy. This deadly disease is estimated to affect around 50 million people around the world. This neurological disorder is believed to be due to excessive electric discharge in the brain and the release of neurotransmitter substances. Antiepileptic drugs are useful but are expensive and have limited supply. Above all, one has to compromise with low efficacy and bear adverse side effects too. This review provides numerous evidences which emphasize on the importance of over thirty herbal medicinal plants and their extracts in the treatment and prevention of epilepsy-related complications. These plants are Vitex negundo, Adansoniadigitata, Abutilon indicum, Allium cepa, Annona senegalenesis, Acormuscalamus, Aegle marmelos, Biophytum sensitivum, Butea monosperm, Canna indica, Datura metal, Cocos nucifera, Citrus colocynthis, Acalypha fruitcosa, Carissa edulis, Commiphora wightti, Clerodendrum infortunatum, Desmodium triflorum, Citrus sinesis, Lobelia nicotinaefolia, Viola tricolor, Leucascephalotes, Phyllanthusamarus, Plectranthusbarbatus, Ocimum sanctum, Nepetabractaeta, Nardostachys jatamansi, Mahua longifolia, Milicia excels, Catharanthus roseus. Reduction in increased Glutathione (GSH), Mylondialdehyde...
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Posted by admin on Jul 31, 2021 in |
Hypertension or elevated blood pressure (BP) is a serious medical condition that significantly increases the risks of heart, kidney, brain, and other diseases. In persons with normal BP and uncomplicated essential hypertension, BP falls to the lowest levels during the nighttime sleep, and rises suddenly with morning awakening, and reaches the peak during the initial h of diurnal activity. The optimum therapy only results when the right amount of drug is delivered to the right targeted organ at the most suitable time. The present research aimed to develop a chronotherapeutic drug delivery system of combination drugs using mini-tablets technology, which can be administered at bedtime and releases Amlodipine within 2 h followed by the rapid release of Losartan after the lag time of 6 h. The developed mini-tablets were evaluated for compatibility studies, pre-and post-compression parameters. The compatibility studies indicate no chemical reaction, pre-compression parameters indicate good flow properties, and post-compression parameters were within limits. The obtained results of in-vitro studies have shown that Amlodipine and Losartan were not...
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Posted by admin on Jul 31, 2021 in |
In this article, an attempt was made to develop molecular docking studies on active metabolites of Prasugrel, Clopidogrel, and Ticlopidine acting as protein P2Y12 inhibitors. Molecular docking analysis was performing by using autodock version 4.3 adjoin with discovery studio to better understand the interactions between P2Y12 targets and inhibitors in this series. Hydrophobic and hydrogen bond interactions lead to the identification of active binding sites of P2Y12 protein in the docked complex, signifying the affection of active Metabolite of Prasugrel is more than other active metabolites of ticlopidine and clopidrogrel. The present study may lead to the discovery of therapeutically potent agents against clinically very important cardiovascular disorders, including arterial thrombosis, Hypertension, embolism etc. cardiac diseases. Hence the computer-aided drug design docking model proposed in this work can be employed to design the metabolites of Clopidogrel, Prasugrel, and Ticlopidine with specific P2Y12 inhibitory activity and futuristic active metabolites...
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Posted by admin on Jul 31, 2021 in |
Hybrid molecules, furnished by combining coumarin and pyrazoles, have been synthesized in the present study. In addition, the binding ability of these coumarin-based molecules has been investigated for Nickel and less studied lanthanum. Lanthanum and nickel complexes with 4-hydroxy-3-((4-hydroxy-2-oxo-2H-chromen-3-yl)(3-(4-nitrophenyl)-1-phenyl-1H-pyrazol-4-yl)methyl)-2H-chromen-2-one (4a) and 4-hydroxy-3-((4-hydroxy-2-oxo-2H-chromen-3-yl)(1-phenyl-3-p-tolyl-1H-pyrazol-4-yl)methyl)-2H-chromen-2-one (4b) were synthesized using lanthanum nitrate hexahydrate (La(NO3).6H2O) and nickel dichloride hexahydrate (NiCl2.6H2O). The synthesized complexes 5a-d were isolated and characterized by IR, Mass, and 1HNMR spectroscopy. The spectra of complexes 5a-d were interpreted on the basis of comparison with the spectrum of the free ligand. These complexes were screened for DNA photocleavage activity. Two complexes, 5a, and 5b, gave significantly good results found to degrade both forms of DNA (SC and NC). Our data give the reason to conclude that these compounds can act as lead compounds and should be submitted to further more detailed biological...
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