Posted by admin on Jul 31, 2019 in |
One of the major problems faced by the pharmaceutical industry is to maintain the quality and efficacy of herbal drugs due to the lack of purity of herbal raw materials. Furthermore, using traditional identification methods to identify the correct plant part needed for the preparation of herbal medicine can be difficult. Creating a novel system to assess the quality of a medicinal herb and to discriminate adulterants from authentic raw material is essential. There is a lot of confusion regarding nomenclature and originality of Valerian available in the market. The objective of the present work is to develop a molecular tool for accurate identification of dry root samples. The isolation of DNA is the first step in developing this technology. The methods employed for extracting DNA from fresh and dried root samples of medicinal plants, however, are time-consuming and yield DNA in lesser quantity and low purity due to the presence of high levels of polysaccharides, phenolics and other secondary metabolites in these samples. In this study, an easy...
Read More
Posted by admin on Jul 31, 2019 in |
Objective: Oecophylla smaradina (Formicidae) is an ant evaluated for its variety of medicinal uses. The objective of this study to evaluate the anti-ulcer activity using albino rats. Methods: The albino rats of either sex were divided into four groups. Ethanolic extract of Oecophylla smaradina (EEOS) was tested in the dose of 200 and 400 mg/kg p.o. respectively against by pylorus ligation induced ulcer models in albino rats. Results: Both the concentration (200 and 400 mg/kg p.o.) of extract have provided significant activity but EEOS 200 mg/kg, p.o, extracts were less effective when compared to EEOS 400 mg/kg, p.o. The antiulcer activity was accessed by evaluate the ulcer index in the test and standard drug treated group and also estimated the gastric volume, total acid, and free acid in the pylorus-ligated rats. Conclusion: The present study was revealed that ethanolic extract of Oecophylla smaradina have antiulcer...
Read More
Posted by admin on Jul 31, 2019 in |
Nanotechnology is emerging as a field in pharmacy and medicine that is expected to elicit significant therapeutic benefits especially in the field of drug targeting. The development of effective nanocarriers capable of carrying therapeutic agents specifically and safely to a desired site of action is one of the most challenging tasks facing drug formulation researchers. Serious research attempts had been conducted to reformulate and add new dimensions to the existing blockbuster therapeutic agents to achieve and maintain therapeutic breakthroughs. Integration of nanocarriers therapeutic agent delivery technologies in pre-formulation work accelerate the development of new therapeutic moieties and help in the reduction of attrition of new molecular entities caused by undesirable biopharmaceutical and pharmacokinetic properties. Careful modification of physicochemical properties of nanocarriers provides improved control over the pharmacokinetics and pharmacodynamics of the encapsulated therapeutic agents relative to free drugs that would typically lead to a superior therapeutic index of the encapsulated agent. Nanocarriers vary from biological substances such as albumins, proteins, peptides, and phospholipid liposomes, to chemical substances such as...
Read More
Posted by admin on Jul 31, 2019 in |
Objectives: The objective of this research was dose reduction and toxicity reduction. Dose reduction: various anti-cancer drugs are very costly, and their high dose increases cost. If bioavailability is enhanced, the dose shall be reduced thereby; the cost will also decrease. Dose reduction will also reduce toxicity, and the preparation will become more tolerable. Method: In this study, the nanoparticles were developed by using a modified method with the drug cisplatin, which was later evaluated for stability, toxicity, and therapeutic efficacy using various in-vitro and in-vivo techniques like SRB assay. Results: The resulting dosage form found to be more affected and less toxic than the marketed preparation of drug cisplatin, which is i.v. injection. As cisplatin is a platinum compound and has the biggest drawback of the toxic side effects, which is making the chemotherapy less acceptable but with the preparation of nanoparticles side effects were minimized without harming the therapeutic efficacy. Anti-cancer agents have several adverse side effects and high levels of toxicity, e.g., Hair loss due to...
Read More
Posted by admin on Jul 31, 2019 in |
Boerhavia diffusa is a species of flowering plant in the four o’clock family, Boerhavia belongs to family Nyctaginaceae the plant holds the tremendous potential of medicinal value and has been traditionally used in various ailments like syphilis, leukoderma, blood disorders to name a few. The present study focuses on the GC-MS analysis of extracts of all the plant parts of B. diffusa which revealed the presence of certain bioactive compounds like kaempferol, luteolin, quercetin and so forth. A total of about 20 bioactive compounds were identified. In Boerhavia diffusa in all plant parts roots, stems and leaves kaempferol is observed maximum. Total amount of flavonoids was maximum in leaves and minimum in stem. Antimicrobial activity of the extracts was assayed against pathogenic bacteria and fungi. In B. diffusa, flavonoids extracted from leaf were highly active against F. oxysporium, against bacterial strains flavonoids from leaves were highly active and showed maximum activity against E. coli. The study thus infers that the presence of bioactive components may be the principle behind the...
Read More
