Posted by admin on Aug 31, 2025 in |
Strobilanthes hamiltoniana (Paalkurinji), a perennial herb of the Acanthaceae family, has traditional use in treating ulcers, diabetes, arthritis, and wounds. S. hamiltoniana leaves were extracted using ethanol, chloroform, and water, and screened for phytochemicals using standard protocols. LC-MS analysis was used to identify flavonoids. Antioxidant activity was evaluated via DPPH, HRS, and FRAP assays, while anti-inflammatory activity was assessed using the NO scavenging assay. Additionally, DFT (B3LYP/6-311G(d,p)) calculations and molecular docking were performed to investigate interactions with antioxidant-related proteins: monoamine oxidase-B, catalase, cytochrome P450, and NFE2-related factor 2. Based on the DPPH assay, aqueous and chloroform extracts showed 25.74% and 45.94% inhibition, while ethanol and methanol extracts exhibited higher inhibition at 89.10% and 86%. HRS ranged from 25.5% to 86.4%, with ethanol extract showing the highest activity (86.4%) at 300 μg/ml and an IC₅₀ of 25.54 μg/ml. All extracts were effective in the FRAP assay, with ethanol showing the highest activity (79.41%, IC₅₀ = 28.24 μg/ml). In the NO scavenging assay, ethanol again showed the strongest activity (80.41%, IC₅₀ = 26.26 μg/ml). Molecular docking revealed catechin had...
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Posted by admin on Aug 31, 2025 in |
Introduction: Schizophrenia is a multi-factorial neuropsychiatric disorder, influenced by environmental and genetic factors. The catechol-O-methyltransferase (COMT) gene is a crucial for the metabolism of dopamine. It has been thoroughly investigated for its potential role in SCZ. At the same time; several variants in the COMT gene have been reported in diverse populations in South Karnataka but remain unexplored. Aim: To assess the novel variants related to the COMT gene and their correlation with SCZ symptoms and other health issues in patients. Materials and Methods: The study was carried out on 80 patients aged between 18 and 60 years; the results were compared with healthy controls of 80. The samples of blood were collected for the DNA extraction. PCR was used to amplify the COMT gene, followed by sequencing to identify variants. Standardized scales were used for gauging the severity of the symptoms. Results: Two novel changes in a single nucleotide (SNPs) (non-synonymous) were identified in the COMT gene in exon -4 of two female SCZ patients out of 80...
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Posted by admin on Aug 31, 2025 in |
Background: Drug Utilization Study offers useful methods for teaching and training in drug therapy. In our setting, there is no such study that describes the use of drugs post-operatively. As a result, this study was conducted to investigate the post-operative drug utilization pattern in indoor post-operative patients. Aim: To study the prescribing trends of drugs used in indoor adult post operative patients in general surgery unit. Methods: Prospective observational study was conducted in post operative patients in General Surgery wards and ICU for 12 months at a tertiary care teaching hospital. Results: Total 600 cases were studied. Majority of the patients managed were males (64.5%). Most of the patients were in 18-40 years age group (49.66%) and from rural background 69.33% (416). The most common surgical procedure performed was Appendicectomy (29%). A total of 4437 drug products were prescribed. Average number of drugs prescribed per encounter were 7.39±2.56. Only 41.08 % of the drugs were prescribed by Generic name. Antibiotics were prescribed to 99.66% of the encounters. Antibiotics per...
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Posted by admin on Aug 31, 2025 in |
Tuberculosis (TB) continues to rank among the world’s most serious health problems despite the remarkable biomedical achievements. The objective of the study is to describe and characterize the adverse drug reactions associated with Anti Tubercular Therapy (ATT) in a tertiary care hospital. This was a cross sectional study done in the Department of Thoracic medicine, Government Medical College Krishnagiri between May 2023 and July 2023(3 months). Around 240 patients taking anti-tubercular drugs were screened and 98 patients (40.8%) among them were found to have adverse reactions to the therapy. Incidence of ADR was highest (8.3%) among (21-30) and (51-60) age groups. Among the type of detected adverse drug reactions induced by anti-TB drugs, gastritis (8.3%) was the most common, followed by rash (5%), hepatitis (4.2%) with hard of hearing (0.8%) and vision abnormality (0.8%) being the least common. Causality assessment revealed around 64 ADRs (26.7%) had possible relation to the drug usage. severity assessment of ADRs induced by ATT revealed mild in 52 patients (21.7%), moderate in 44 patients...
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Posted by admin on Aug 31, 2025 in |
Invasomes, within the scope of transdermal medication delivery and cosmetic formulations, nowadays have emerged as impressive technology and are described in comprehensive detail in this review paper. Essentially, invasomes are built from a unique substance, techniques, and processes that can enable active compounds to penetrate easier into the skin than standard liposomes, with the help of phospholipids, ethanol, and terpenes while remaining within the skin boundaries and decreasing systemic absorption. This paper discusses the advantages of invasomes over the conventional delivery systems, including enhanced bioavailability and targeted delivery of therapeutic agents. Other aspects discussed include advancements in nanotechnology and process automation to reduce the production cost and enhance the scalability without any compromise on quality. Review of applications of invasomes in dermo-cosmetic products focuses on their role in treating skin dysfunctions. In summary, it is underscored in this paper that invasomes can revolutionize skincare formulations and hence help overcome multiple dermatological...
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