Posted by admin on Aug 31, 2026 in |
Background: India is one of the highest TB burden countries with an annual incidence 199 TB cases/100,000 population and the estimated death rate in the year 2023 among all forms of TB was 23/100,000 population. The variables like undernutrition or malnutrition at treatment initiation, low BMI, presence of comorbidities and severe stunting were associated with unfavourable TB treatment outcomes. Material and Methods: The study was a prospective cohort study carried out at DTC Rohtak and study period was 6 months i.e. January 2024 – June 2024. The study recruited all newly diagnosed sputum positive pulmonary tuberculosis adult age ≥18 years patients registered during the period Jan 2024-June 2024 on Nikshay portal for DTC urban TU Rohtak. Results: A total of 65 study subjects; majority of study subjects 57 (87.7%) were cured, 7 (10.8%) study subjects completed treatment while one study subject was died during course of treatment. In the multivariable analysis, the variables like: age, caste, marital status, education, occupation, BMI, DM and AFB Grading were found statistically significant...
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Posted by admin on Aug 31, 2026 in |
Valeriana wallichii DC. (Valerianaceae), known as Tagara, is a slightly hairy, tufted perennial herb growing 15-45 cm tall. It has a thick, horizontal rhizome with many fibrous roots and bears small white to pale pink flowers in compact terminal corymbs. It is valued for sedative, anxiolytic, antioxidant, and antidepressant properties. This review aims to provide a detailed and updated overview of the pharmacological properties, therapeutic potential, and mechanisms of action of Valeriana wallichii, focusing on its traditional uses and recent experimental evidence. A systematic literature review was conducted, scrutinizing classical Ayurvedic texts alongside contemporary scientific databases such as SciFinder, Google Scholar, PubMed, and Scopus. Evidence indicates that methanolic and aqueous extracts of Valeriana wallichii exhibit significant anti-inflammatory effects. Extracts derived from roots and rhizomes demonstrate sedative, anxiolytic, antioxidant, and antidepressant activities. Leaf extracts show antimicrobial and additional anti-inflammatory properties. Mechanistically, these biological effects are attributed to potentiation of GABAergic neurotransmission, modulation of monoaminergic systems (serotonin, dopamine, norepinephrine), enhancement of antioxidant defenses to mitigate oxidative stress, and stabilization of neurochemical...
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Posted by admin on Aug 31, 2026 in |
Oxidative stress and chronic inflammation play a pivotal role in the pathogenesis of several non-communicable disorders, including neurodegenerative, metabolic, and cardiovascular diseases. Plant-derived flavonoids have gained increasing scientific attention owing to their antioxidant and anti-inflammatory properties. Citrus medica L. (citron), an ethnomedicinal citrus fruit, is recognized as a valuable source of bioactive phytochemicals, particularly rutin. The present investigation aimed to evaluate the nutritional composition, antioxidant potential, and prospective anti-inflammatory activity of Citrus medica flesh juice through integrated experimental and computational approaches. Proximate composition analysis was performed using standard AOAC protocols, while antioxidant activity was determined by the Ferric Reducing Antioxidant Power (FRAP) assay. Rutin content was quantified spectrophotometrically using a rutin calibration standard. Molecular docking analysis was carried out to evaluate the interaction of rutin with Toll-like receptor 4 (TLR-4), a key regulator of inflammatory signaling pathways. In addition, pharmacokinetic and drug-likeness properties of rutin were predicted using the SwissADME web platform. The proximate analysis demonstrated that Citrus medica L flesh juice possessed high moisture content (80%), along with...
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Posted by admin on Aug 31, 2026 in |
Background: Adverse drug reactions (ADRs) are a global health concern, contributing to morbidity, prolonged hospital stays, and increased healthcare costs. In India, underreporting and inconsistent causality assessment hinder pharmacovigilance. WHO UMC scale standardizes ADR classification; semi urban hospital data remain limited. Objective: To systematically analyze ADRs reported in a semi urban tertiary hospital in Hosur, Tamil Nadu, using the WHO UMC causality assessment scale, and to evaluate their severity, preventability, and drug class distribution. Methods: A prospective observational study was conducted over one year at St. Peter’s Medical College & Hospital. All spontaneously reported ADRs from inpatients and outpatients were included. Data were collected using Pharmacovigilance Programme of India (PvPI) forms and assessed with the WHO UMC causality scale, Hartwig and Siegel severity scale, and Schumock and Thornton preventability criteria. Results: A total of 36 ADRs were documented in patients aged 9 months to 80 years, with slight female predominance. Cephalosporins (42%) were leading, followed by contrast agents (22%) and NSAIDs (11%). Dermatological reactions were most frequent, systemic events...
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Posted by admin on Aug 31, 2026 in |
A stable multicomponent crystalline phase involving an anti-cancer agent (5-Fluorouracil, 5-FU) and an immunomodulator (Levamisole, LM) was developed through a systematic descriptor-guided screening workflow. Binary 5-FU/LM combinations failed to yield new solid phases, as assessed by Fourier Transform Infrared Spectroscopy (FTIR), a finding rooted in the complete absence of hydrogen bond donor functionality (HBD = 0) in levamisole. A composite descriptor-based coformer ranking algorithm, implemented in Python using RDKit, evaluated nine pharmacopoeially acceptable coformers against hydrogen bond donor-acceptor complementarity, topological polar surface area (TPSA), and LogP compatibility. Citric acid (CA) ranked first, driven by its hydrogen bonding capacity (HBD = 4, HBA = 4) and elevated TPSA. Twelve ternary formulations (5-FU/LM/CA) were prepared by solvent evaporation and anti-solvent addition across three molar ratios in water and EtOH:Water co-solvent systems. Quantitative FTIR descriptors served as inputs to a gradient boosting classifier for objective formulation ranking. F11 (1:2:1 molar ratio, anti-solvent addition, EtOH:Water) and F12 (same composition, solvent evaporation) emerged as the highest-ranked systems. New crystalline phases were confirmed in both...
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