Posted by admin on Sep 1, 2013 in |
An HPLC method was developed and validated to determine felodipine and related substances. A C18 column (5μm, 250 ×4.6 mm) was used for the separation at room temperature, with methanol: acetonitrile: water (50:15:35%, v/v/v) as the mobile phase at the flow rate of 1.0mLmin−1. The detection wavelength was 238 nm. The validation characteristics included accuracy, precision, specificity, linearity, and robust, and stability-indicating. The method showed good linearity for felodipine and its related substances with correlation coefficients in the range of 5.05-40.4μg/mland 0.31-15.50μg/ml. Method accuracy was assessed for felodipine and its related substances at three levels, the recovery ranged from 98.86 to 101.03%. The intermediate precision were 0.42% for felodipine and was 1.01% for the related substances (n = 9). Limit of detection and quantification for felodipine and its related substances were 1 and 4ng, respectively. The solution remains stable within eight hours at room temperature. Finally, the method was demonstrated to be robust, resistant to small variations of chromatographic variables. This method is fast, simple, can be used for...
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Posted by admin on Sep 1, 2013 in |
In the present work in mathematical modeling, quantitative structure activity relationship (QSAR) studies were performed on some quinolone derivatives as a potential antibacterial agent using statistical work. The regression analysis of the data has shown that the activities of the compound can be modeled excellently in bi-parametric model.A heurisimatedtic algorithm selects the best multiple linear regression(MLR) equation showed the correlation between the observed values and the estimated values of activity is very good(R=0.9849, R2 =O.9700, PRESS=0.0185, 14Rcv2″> =0.9692, SPRESS =7.8631). The results are discussed...
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Posted by admin on Sep 1, 2013 in |
The past decade has witnessed intense interest in nutraceuticals in which phytochemical constituents have long-term health promoting or medicinal qualities. Secondary products have a variety of functions in plants; it is likely that their ecological function have some potential medicinal effects for humans. Between 1990 and 2020, deaths from non-communicable diseases and injury are expected to rise from 33 million to 58 million, with a similar proportional increase in mortality. It’s been estimated that by 2020, chronic diseases will account for almost three-fourths of all deaths. World Health Organization encourages the addition of secondary metabolites of plants in life saving drugs. Disorders like hypertension, diabetes mellitus, cardio vascular diseases, stroke, cancer, kidney disease and other diseases of unknown etiology are increasing due to poor diet pattern, stress, loss of physical activity, toxic substance in foods etc. Nutraceuticals and phytomedicines in the plant help in preventing these metabolic diseases without any side effects. Identification of these phytomedicines and Nutraceuticals and regular incorporation into the diet helps to increase the longevity...
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Posted by admin on Sep 1, 2013 in |
The Bt brinjal is a suite of transgenic Brinjals created by inserting a crystal protein gene (Cry1Ac) from the soil bacterium Bacillus thuringiensis into the genome of various brinjal cultivars. The dispute over Bt Brinjal still continues and a proper decision has not yet been reached neither by the Ministry of Environment and Forests nor by the general public and scientists. Currently farmers rely exclusively on the application of pesticides to control EFSB and to produce blemish-free eggplant fruit. Small and marginal farmers use 25-80 sprays of pesticides in Brinjal cultivation. Therefore, alternative strategies of IPM will help to control and manage the...
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Posted by admin on Sep 1, 2013 in |
HVAC maintain both comfort and safety of indoor air quality. The challenge of maintaining high product quality while simultaneously reducing production costs can often be met through investments in energy efficient technologies and energy efficiency practices. The greatest opportunities for energy efficiency exist at the design stage for HVAC systems in new industrial facilities. By sizing components of HVAC systems generally include dampers, supply and exhaust fans, filters, humidifiers, dehumidifiers, heating and cooling coils, ducts, and various sensors properly and designing energy efficiency into a new facility, an industry can minimize the energy consumption and operational costs of its plant HVAC systems from the outset. Optimizing system design and operations, such as minimizing laboratory ventilation, can also lead to significant reductions in energy use. Energy efficiency improvement is an important way to reduce these costs and to increase predictable earnings, especially in times of high energy price volatility. There are a variety of opportunities available at individual plants in the industry to reduce energy consumption in a cost-effective...
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