Posted by admin on Sep 1, 2013 in |
Pharmaceutical product and active pharmaceutical ingredients (APIs) can be contaminated by other pharmaceutical products or APIs, by cleaning agents, by microorganisms or by other materials e.g. air borne particle, dust, lubricants, raw materials, intermediates. Mainly cleaning is performed to remove product and non-product contaminating material. Ineffective cleaning can lead to adulterated product, which may be from previous product batches, cleaning agent or other extraneous material introduced into generated by the process. In many cases, the same equipment may be used for processing different products. To avoid contamination source or facility configuration there is a need to ensure that cleaning procedure must strictly follow carefully established and validated method of...
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Posted by admin on Sep 1, 2013 in |
Medicinal plants form the backbone of traditional system of medicine in India. Biotechnological and Pharmacological studies have acknowledged the value of medicinal plants as potential source of bioactive compounds. Phytochemicals from medicinal plants serve as lead compounds in drug discovery and design. Medicinal plants are rich source of novel drugs that forms the ingredients in traditional systems of medicine, modern medicines, nutraceuticals, food supplements, folk medicines, pharmaceutical intermediates, bioactive principles and lead compounds in synthetic drugs. Aloe is a genus containing about four hundred species of flowering succulent plants belonging to Liliaceae family. Aloe vera is as old as civilization and through history it has been used as a popular folk medicine. It is present in the arid regions of India. Aloe vera has valuable medicinal properties and is commercially used in pharmaceuticals, cosmetics and food industries. Since ancient time Aloe vera L. are using in many herbal preparations. The Aloe vera plant contains the important antioxidant components such as vitamins (A, C and E), B (thiamine), niacin, B2...
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Posted by admin on Sep 1, 2013 in |
, 3-Benzodioxole ring system present in various naturally occurring molecules. Various synthetic molecules having 1, 3-Benzodioxole ring system have shown various biological activities. Stiripentol and Antiepilepserine are recently developed antiepileptic drugs which contain 1, 3-Benzodioxle rings system in core moiety. In the present work I have focused on the anticonvulsant activity of 1, 3-Benzodioxole ring system based...
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Posted by admin on Sep 1, 2013 in |
Allium sativum linn (Garlic) belong to family Liliaceae has been widely known since ancient times for medicinal use and for flavouring food. It contains large amount of sulphur containing compounds like Alliin, Allicin, Ajoene, Diallyl sulphide, Diallyl disulphide Diallyl trisulfide, Vinyldithiines which has beneficial activity including Antithrombotic, Anticancer, Antiviral, Antifungal and Antimicrobial, Anti-inflammatory etc. Ajoene is known as an inhibitor of platelet aggregation induced by all known agonists which also a good inhibitor of tumour and antifungal property. The present study deals with pharmacognostical parameters for bulb of Allium sativum which mainly consist of the detailed macromorphology of cloves and bulb, microscopy and micrometry of transverse section of cloves of Allium sativum linn which has been carried out by using MOTIC Digital Microscope. The other parameters like physicochemical constant and phytochemical screening were studied. The study will provide referential information for the correct identification and standardization of crude...
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Posted by admin on Sep 1, 2013 in |
Aim: To compare the immunomodulatory effect of Ocimum sanctum and Ocimum basilicum in mice. Methods: Acute oral toxicity test was performed as per OECD -23 guidelines. Maximum dose level of 2000 mg/kg was selected for toxicological evaluation. Delayed type hypersensitivity reaction were carried out for assessment of cell mediated immune functions Result: Administration of Ocimum sanctum and Ocimum basilicum did not produced any mortality or any signs of behavioral changes or toxicity at the dose level of 2000 mg/kg body weight in mice. The result of the present study showed that acute administration of extract of Ocimum sanctum and Ocimum basilicum may be safe as the LD50 may be greater than 2000mg/kg. Treatment with Ocimum sanctum enhanced DTH reaction, which is reflected from foot pad thickness when compared with Ocimum basilicum and control groups whereas a similar effect was observed when compared to the reference drug Aswagandha choorna, which is a well-known immune booster. Conclusion: Increase in DTH reaction in mice in response in T cell dependent antigen revealed...
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