Posted by admin on Sep 1, 2012 in |
NLC are innovative vehicles introduced to overcome some limitations of SLN. Particularly, NLC, composed of a solid lipid and a certain content of liquid lipid (oil), show improved drug entrapment efficiency and an increased stability during storage with respect to SLN. Furthermore, NLC, maintaining their solid state, can control the API release from the matrix. To formulate Nanostructure lipid carriers of an anti-inflammatory drug Betamethasone Dipropionate. To conduct in vitro Diffusion studies using dialysis membrane. To Ex vivo permeation study using rat skin. To conduct stability studies at 4°C and room temperature and to evaluate entrapment efficiency at various time...
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Posted by admin on Sep 1, 2012 in |
This study was designed to investigate the ameliorative effect effect of Hygrophila auriculata (H. auriculata) on lipid peroxidation (LPO) in N-nitrosodiethylamine induced Hepatocellular Carcinoma (HCC) in rats. Experimental rats were divided into different groups: normal, N-Nitrosodiethylamine induced hepatocellular Carcinoma bearing rats, H. auriculata treated hepatocellular carcinoma bearing rats, (200 mg/kg body weight, doses for 28 days), Animals treated with plant extract alone for 28 days. After the treatment period of 28th day , effect of H.auriculata on LPO in serum , liver and kidney of control and experimental animals were assayed and compared. Under basal and in the presence of inducers (H2O2), the levels of LPO were increased significantly (p<0.001) in group II cancer bearing animals where as the levels of LPO in the presence of ascorbic acid and FeSO4, were not statistically different. In group III plant extract treated animals, significant decrease on LPO was observed. However, the changes in the above parameters were comparable with control.Thus, methanolic extract of H. auriculata ameliorated the LPO which is associated...
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Posted by admin on Sep 1, 2012 in |
Cefuroxime is a 2nd-generation cephalosporin and Sulbactam is a β-Lactamase inhibitor. The combination formulation is used for the treatment of lower respiratory tract infection. Two new, simple, accurate and precise UV spectrophotometric methods have been developed and validated for the simultaneous determination of Cefuroxime Sodium (CEF) and Sulbactam Sodium (SUL) in their combined dosage forms. First method is based on simultaneous estimation of Cefuroxime at 279nm and Sulbactam at 259 nm, while other Q‐absorption Ratio method using two wavelengths, 259nm (λmax of SUL) and 272nm (Isoabsorptive point). 0.01 N NaOH was the solvent used in all methods. Cefuroxime Sodium showed linearity in the range of 8-32μg/mL and Sulbactam sodium showed linearity in the range of 4-16μg/mL in all the methods. All methods were validated statistically and recovery studies were carried out. All methods were found to be accurate, precise and reproducible. These methods were applied to the assay of the drugs in marketed formulation, which were found in the range of 98.0% to 100.0% of the labelled value for...
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Posted by admin on Sep 1, 2012 in |
Micro bubbles are small spherical type of bubble which consists of a gas, they are separated from each other, so they cannot agglomerates. Actually, they have size range in micrometers usually 1-100 micrometer. They are capable of penetrating even into the smallest blood capillaries & releasing drugs or genes, incorporated on their surface, under the action of ultrasound. Microbubbles in general have a wide variety of applications. They are used as a contrast agent in diagnosis. They are widely applicable in gene delivery due to its very important silent feature. Majorly main huge research is going on drug delivery by microbubble with ultra sound. Most of the physicians today prefer imaging with ultrasound in combination with microbubbles compared to other diagnostic techniques for low cost and...
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Posted by admin on Sep 1, 2012 in |
Metoprolol is a beta1-selective (cardio selective) adrenergic receptor blocking agent used in the treatment of Hypertension. The purpose of this investigation is to improve bioavailability by preparing a gastroretentive drug delivery system. Floating tablets of Metoprolol Succinate were prepared by employing two different grades of HPMC K4M and HPMC E15M in different concentrations by effervescent granulation technique. These grades of HPMC K4M and HPMC E15M were evaluated for their gel forming properties. Sodium bicarbonate was incorporated as a gas-generating agent. The tablets were evaluated for uniformity of weight, hardness, friability, drug content, in vitro buoyancy and dissolution studies. The prepared tablets exhibited satisfactory physicochemical characteristics. All the prepared batches showed good in vitro buoyancy. The tablet swelled radially and axially during in vitro buoyancy studies. It was observed that the tablet remained buoyant for 6-8 hours. A combination of 5:1 sodium bicarbonate and magnesium stearate was found to achieve optimum in vitro buoyancy. The tablets with HPMC K4M and HPMC E15M with drug in the ratio of 1:1:2 were...
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