Posted by admin on Sep 1, 2012 in |
Non enzymatic glycation takes place when elevated levels of reduced sugars react with amino groups of proteins and is called as advanced glycation end products (AGEs) are responsible for Diabetes Mellitus. Hydroalcoholic extract of Whitton root (Eulophia nuda) was tested for in-vitro inhibition of non-enzymatic glycation of Immunoglobin G. Plant extracts have their own importance and now being studied extensively due to having little or no side effects in all aspects of life sciences from botany to medicine in biochemical research. In present study Whitton root was selected and used to check the glycation inhibitory activity in-vitro condition. Various combinations of glucose, protein and Whitton root extracts were made under in vitro conditions and their activity was monitored with Trichloro acetic acid treatment method at 350 nm. Glycated products/ AGEs were more with high glucose and high protein concentration and these were decreased by highest concentration of Whitton root extract i.e. 30 mg/mL or 300 μL. Lower concentrations of plant extract produced either no or least response against advanced glycation end products...
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Posted by admin on Sep 1, 2012 in |
Angiogenesis is process of new blood vessel formation that occurs under both normal and pathological conditions. In the normal state, two distinct processes can be seen. One utilizes endothelial progenitor cells (EPC) and the second utilizes existing vasculature to generate new vessels. The healthy body controls angiogenesis through a series of “on” (angiogenesis-stimulating growth factors) and “off” (angiogenesis inhibitors) switches. However, the structures formed are often functionally abnormal; possibly due to an imbalance in the angiogenic process Angiogenesis represents an excellent therapeutic target for the treatment of cardiovascular disease. The healing of damaged tissues urgently required the rapid formation of new vessels which is brought about by various growth factors: VEGF, FGF, PDGF, Angiopoitins and Ephrins. Therapeutic angiogenesis is the clinical use of methods to enhance or promote the development of collateral blood vessels in ischemic, thrombotic, atherosclerotic tissue. This new form of treatment is an alternative to high risk percutaneous coronary intervention or coronary artery bypass surgery. There are three major ways to promote angiogenesis: protein therapy (by...
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Posted by admin on Sep 1, 2012 in |
Cervical cancer, a potentially preventable disease, remains the second most common malignancy in women worldwide. Despite the tremendous progress that has been achieved in the screening and management of cervical cancer, there is still a need for clinically relevant prognostic biomarkers to monitor the response of patients to various therapies and to predict the chances of recurrence and recovery. Since cancer recurrence is the most common treatment failure in patients with advanced tumor, increasing knowledge about new biologic markers and better ability to predict risk of cancer recurrence is very important for construction of more effective treatment strategies. The biomarkers, which indicate the response of cancer patients to various therapy, predict response to particular therapies and choose the drug that, most likely to yield a favorable response in a given patient, identify patients with a high probability of adverse effects of a treatment and determine whether a therapy is having the intended effect on a disease and whether adverse effects arise. In this literature study we have done a...
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Posted by admin on Sep 1, 2012 in |
Valsartan is an orally administered ACE inhibitor for the treatment of hypertension and cardiac failure, but its solubility and oral bioavailability are poor. The objective of investigation is to formulate a microemulsion drug delivery system of valsartan using minimum surfactant concentration that could improve its solubility and oral bioavailability. Valsartan microemulsion were prepared by Phase-titration method. The composition of optimized formulation consist of Capmul MCM(Oil), Tween 20 (Surfactant),PEG 400(Co-Surfactant) and it contains 40 mg of Valsartan.Pseudo-ternary phase diagrams were plotted to check for the micro-emulsification range. Prepared microemulsion formulations were tested for micro emulsifying properties and the resultant microemulsion were evaluated for robustness to dilution, viscosity, drug content, thermodynamic stability studies and in-vitrodissolution. The optimized microemulsion formulation further evaluated for thermodynamic stability studies, particle size distribution, and zeta potential to confirm the stability of the formed Microemulsion. Resultant microemulsion optimized formulation (F2) shows drug release (99.71%), droplet size (36 nm), viscosity (0. 8872 cP), Zetapotenial (-38.8 mV) and infinite dilution capability. The formulation was found to show a significant...
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Posted by admin on Sep 1, 2012 in |
Lantana camara is more popular as toxic weed rather than medicinal plant in most of the countries responsible for infesting pastures, grazing lands, orchards and crops like, tea, coffee, oil palm, coconut and cotton, and reduces the economic viability of the crops. This plant can grow even in extreme harsh climatic conditions of tropical and sub-tropical areas and has become naturalized worldwide as an ornamental plant including India. The stem, root and leaves contain many of the bioactive compounds responsible for various therapeutic applications such as cancers, chicken pox, measles, asthma, ulcers, swellings, eczema, tumors, high blood pressure, bilious fevers, catarrhal infections, tetanus, rheumatism, malaria, antiseptic, antispasmodic, carminative and diaphoretic. Besides this, it has some toxic effect by accidental ingestion among the livestock. Best alternate uses of West Indian Lantana started by the people, as it is difficult to eradicate such as household furniture like tables, chairs etc. are made from the stalks.. Present review indicating that Lantana camara is a versatile ornamental plant species having economic importance and...
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