Posted by admin on Sep 1, 2012 in |
Pregnancy can be the most paranormal and exciting time for expectant mother. Nature provides us with many tools for supporting both the mother and baby through this time of growth and renewal, to strengthen the spirits and body to promote a healthy pregnancy and birthing process. Pregnant and lacting mother need to be educated on the need for caution when using herbs during pregnancy and lactation particularly in view of lack of complete information. The women self administer herbal medicines both before and after pregnancy often without any recognition of their potential hazards. The use of herbal supplements in pregnancy and lactation is likely to be relatively high and its importance ascertains what supplements women are taking. Pregnancy and lactation care providers should be aware of common herbal supplements used by women and of evidence regarding potential benefits or harm. Midwives and obstetricians have an obligation to facilitate women’s wishes without condemnation, but this must be tempered with accurate information to ensure that use of herbal remedies in pregnancy...
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Posted by admin on Sep 1, 2012 in |
Cassia nodosa Bunch.is an ornamental tree belonging to family Leguminosae, popularly known as Pink Shower is a perennial tree. Laboratory evaluations were made to asses the study of primary metabolites in different plant parts of Cassia nodosa Bunch. The highest amount of soluble sugars (10.27mg/ gdw), lipids (32.36mg/gdw), phenols (20.0mg/gdw), DNA (11.78mg/gdw) and Chlorophyll- a+b (0.94mg/gdw) was observed in pods, ascorbic acid (0.867 mg/gdw), proteins (115.0mg/gdw), RNA (4.60mg/gdw) and carotenoids (0.554mg/gdw) in leaves and starch (10.02mg/gdw) in stems. Similarly lowest amount of proteins (39.48mg/gdw), phenols (4.67mg /gdw), RNA (0.49mg/ gdw) and DNA (1.76mg/gdw) was observed in leaves, starch (3.76mg/gdw) in flowers, soluble sugars (2.45mg/gdw), lipids (3.48mg /gdw), ascorbic acid (0.089mg/gdw) in...
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Posted by admin on Sep 1, 2012 in |
The colon is the terminal part of the GIT which has gained in recent years as a potential site for delivery of various novel therapeutic drugs, i.e. peptides. However, colon is rich in microflora which can be used to target the drug release in the colon. Colon is a site where both local and systemic drug delivery can take place. Local delivery allows the topical treatment of inflammatory bowel disease. If drug can be targeted directly into the colon, treatment can become more effective and side effects can be minimized. These systemic side effects can be minimized by primary approaches for CDDS (Colon specific drug delivery) namely prodrugs, pH and time dependent systems and microbially triggered system which gained limited success and have limitations as compared with recently new CDDS namely pressure controlled colon delivery capsules (PCDCS), CODESTM (Novel colon targeted delivery system) osmotic controlled drug delivery system, Pulsincap system, time clock system, chronotropic system. This review is to understand the pharmaceutical approaches to colon targeted drug delivery systems...
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Posted by admin on Sep 1, 2012 in |
The fruits of Garcinia pedunculata Roxb. ex Buch.-Ham., G. xanthochymus Hook. f. and G. morella (Gaertn.) Desr. collected from Sonitpur district of Assam, India were evaluated for the antioxidant potential and total phenolic content. The methanolic extract of these fruits were subjected to DPPH (2,2-Diphenyl-1-picrylhydrazyl) assay for determining the free radical inhibition property and Folin Ciocalteu’s method for quantification of total phenolic content (TPC). G. pedunculata Roxb. ex Buch.-Ham. showed highest antioxidant potential with IC50 value 47.03±13.48 µg/ml. All species contains low phenolic content ranging between 1.83±0.62 to 88.2±2.19 mg GAE/g dry extract. No significant correlation between total phenolic content and antioxidant potential was...
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Posted by admin on Sep 1, 2012 in |
High performance liquid chromatography is one of the most accurate methods widely used for the quantitative as well as qualitative analysis of drug product and is used for determining drug product stability. Stability indicating HPLC methods are used to separate various drug related impurities that are formed during the synthesis or manufacture of drug product. This article discusses the strategies and issues regarding the development of stability indicating HPLC system for drug substance. A number of key chromatographic factors were evaluated in order to optimize the detection of all potentially relevant degradants. The method should be carefully examined for its ability to distinguish the primary drug components from the impurities.New chemical entities and drug products must undergo forced degradation studies which would be helpful in developing and demonstrating the specificity of such stability indicating methods.At every stage of drug development practical recommendations are provided which will help to avoid...
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