Posted by admin on Sep 1, 2012 in |
In quest of better anti-amoebic agents, quantitative structure-activity relationship (QSAR) studies were performed on a series of pyrazoline & dioxazoles derivatives with the help of PM5 calculations and geometry optimizations using CAChe software. Multiple Linear Regression (MLR) analysis was performed to derive QSAR models using the descriptors, molecular weight (MW), conformation minimum energy (ɛ), HOMO energy (eHOMO), shape index, basic kappa second order (k2), absolute hardness (h), electronegativity (c), electrophilicity index (ω), molar volume (MV), molar refractivity (MR), LogP (LP), parachor (Pc) and solvent accessibility surface area (SASA). The QSAR models equations of anti-amoebic agents have been developed by using maximum of seven descriptors, in which conformation minimum energy, shape index, molar volume and parchor were present have good predictive powers of correlation coefficients. These models can successfully predict the anti-amoebic activity of any newly discovered pyrazoline and dioxazole derivatives which can later be tested in...
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Posted by admin on Aug 31, 2012 in |
Retraction Note : Shokri N, Azizi E, Akbari Javar H, Fouladdel Sh, Khalaj A, Dinarvand R. In vitro and in vivo evaluation of poly (caprolactone fumarate) nanoparticles. International Journal of Pharmaceutical Sciences and Research. 2012; 3(9):3106-3115. It has come to the attention of the IJPSR Editors that there are substantial overlaps between the text of the above article and the following papers. It has been pointed out that the above study appeared to contain a high level of similarity with two articles by the same authors published as below: Shokri N, Akbari Javar H, Fouladdel Sh, Khalaj A, Khoshayand M, Dinarvand R, Atyabi F, Nomani A, Azizi E. Preparation and evaluation of poly (caprolactone fumarate) nanoparticles containing doxorubicin HCI. Daru. 2011;19(1):12-22. PMID: 22615635. and Shokri N, Akbari Javar H, Fouladdel Sh, Khalaj A, Dinarvand R, Azizi E. Preparation and characterization of crosslinked and non-crosslinked polycaprolactone fumarate (PCLF) NPs as carriers for doxorubicin HCl. Afr J Pharm Pharmacol. 2011;5(7):797-805. Following an internal investigation, it was established that the studies were...
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Posted by admin on Sep 1, 2011 in |
This study was designed to present the observation of the pharmacological properties to the bulb of the plant. The extract of the bulb of Urginea indica Kunth. were collected by using of alcoholic extraction. The anti-inflammatory action of the alcoholic Extract of the bulb of the plant Urginea indica was evaluated in rats (female) against carrageenan induced edema i.e., using plethysmographic method. Besides this method, this extract was also assessed for Cotton pellet test and Hot plate test for anti-inflammatory and analgesic effects respectively. The effects of the extract were compared with the classical anti-inflammatory drug – Ibuprofen. The crude extract and the standard drug were orally administered. A significant anti-inflammatory effect was produced with the Alcoholic Extract of the plant part. This effect was then compared with the effect from the classical anti-inflammatory...
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Posted by admin on Sep 1, 2011 in |
Cordia dichotoma known as lasura, lisora, is a commonly known herb in Indian system of medicine to treat various disorders including diabetes mellitus without any scientific evidences. Therefore this study was designed to investigate in vivo hypoglycemic and antidiabetic potential of methanol extract of fruits of Cordia dichotoma in glucose loaded animals and alloxan induced diabetic animals. In both the models Cordia dichotoma reduce the blood glucose level when compared to diabetic control group and exert a significant hypoglycemic and antidiabetic activity. However the potency of the herb was less than that of standard drug metformin. Cordia dichotoma methanol extract also reduced the rate of body weight loss in normal and alloxan induced diabetic animals. The results of this study revealed the presence of a significant antidiabetic potential of methanol extract of Cordia dichotoma in alloxan induced diabetic rats. On the basis of this further research work is needed to investigate exact mechanism of action and also to isolate the active constituent/s responsible for the...
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Posted by admin on Sep 1, 2011 in |
The present study was designed to investigate in vivo analgesic and cytotoxicity as well as in vitro antibacterial activities of the methanol: ethylacetate (1: 9) extract of the flowers of Peltophorum pterocarpum. Analgesic activity was assayed by acetic acid induced assay method wherein the extract showed moderate activity in a dose dependent manner. In respect of in vivo cytotoxicity, the flower extract of Peltophorum pterocarpum showed moderate activity with 30% cell growth inhibition against Ehrlich Ascites Carcinoma (EAC) cells at a dose of 50mg/kg. Moreover, Antibacterial test were done against five Gram-positive and four Gram-negative bacteria. Flower extract was active against all tested microbial species except Staphylococcus aureus and the zone of inhibition range was found to be 12±0.32 to 18±0.11...
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