Posted by admin on Sep 1, 2011 in |
Extensive research has been carried out from last decades to discover potential constituents from plant sources. Stigmasterol is an important constituent and has been isolated from plants. It is involved in the synthesis of many hormones like progesterone, androgens, estrogens and corticoids. In addition to stigmasterol many of its derivatives like, spinasterol, fucosterol, cyasterone, stigmasterol glucoside, fucosterol epoxide, stigma-4en-3one, 29-fluorostigmasterol etc. have been isolated and their pharmacological aspects has been assessed. This comprehensive account provides information about stigmasterol and its derivatives. The diversity in their pharmacological reports reveals that this constituent is worth further...
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Posted by admin on Sep 1, 2011 in |
Recently much attention has been paid to the application of microemulsion as drug delivery system. Part of this interest appears as a consequence of their transparency, ease of preparation and long-term stability. These properties as well as their ability for incorporating drugs of different lipophilicity are some of the reasons why microemulsions have been thoroughly considered for pharmaceutical purpose. The aim of the present study is to improve the solubility of Terbinafine Hydrochloride, a slightly water-soluble antifungal drug by formulating a microemulsion made up of oil, surfactant and solubilizing agent/cosolvent. Tween 80, ajowan oil and peppermint oil were selected for preparing a microemulsion. Propylene glycol (PG) was used as a solubilizing agent. The effect of formulation variables on droplet size distribution was investigated. Droplet size was measured with Malvern Zetasizer instrument based on Photon Correlation Spectroscopy principle. The mean droplet diameter of microemulsions containing 1% w/w of terbinafine hydrochloride was below 100 nm and for the optimized formulation it was 8.1 nm. The optimized microemulsion was found to be...
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Posted by admin on Sep 1, 2011 in |
A novel, safe, accurate, sensitive and economic Spectrophotometric method was developed by application of mixed hydrotropy using solution containing 45% urea and 5% sodium citrate as hydrotropic solubilizing agent for the quantitative determination of poorly water-soluble budesonide from bulk and tablet dosage form. The solubility of budesonide increases more than 20 times in mixed hydrotropic solution as compared to solubility in distilled water, thus, a mixed hydrotropic solution containing 45% urea and 5% sodium citrate was employed to carry out spectrophotometric analysis precluding use of organic solvents. Budesonide obeyed Lambert Beer’s law in the concentration range of 5 to 30μg/ml (r2= 0.999) in mixed hydrotropic agent with mean recovery was found 98.75±0.63%. The percent concentration in marketed tablet formulation was found 98.56±1.070%. Parameters such as linearity, precision, accuracy, specificity and robustness were studied as reported in the International Conference on Harmonization guidelines. The relative standard deviations for three replicate measurements in five concentrations of samples were always less than 2%. So this method can successfully employ in the routine...
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Posted by admin on Sep 1, 2011 in |
The present study was undertaken to evaluate the in vitro antioxidant activities of hexane, ethyl acetate and methanolic extracts of Holostemma ada kodien root tubers. The above extracts exhibited a dose dependent scavenging activity against DPPH radicals, Superoxide radicals, and Nitric oxide radicals. Further, the MeOH, EtOAC extracts showed relatively higher reducing power compare to that of BHT. TLC of the above extracts using the DPPH as a spraying reagent revealed yellow spots against purple background indicating the presence of potent antioxidant...
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Posted by admin on Sep 1, 2011 in |
There has been considerable interest in the development of novel compounds with anticonvulsant, antidepressant, analgesic, anti-inflammatory, anti platelet, anti malarial, antimicrobial, antimycobacterial, antitumoral, vasodilator, antiviral and antis chistosomiasis activities. Hydrazones possessing an azometine -NHN=CH- proton constitute an important class of compounds for new drug development. Therefore, many researchers have synthesized these compounds as target structures and evaluated their biological activities. These observations have been guiding for the development of new hydrazones that possess varied biological activities....
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