Posted by admin on Sep 1, 2011 in |
A reverse phase HPLC method is described for the determination of Ziprasidone HCl capsule by analytical method. Chromatography was carried out on an ODS C18 column using a mixture of buffer solution, acetonitrile and methanol (45: 40: 15v/v/v) as the mobile phase at a flow rate of 1.5mL/min. Detection was carried out at 230nm. The retention time of the drug was 7-9 min. The method produced linear responses in the concentration range of 50-150µg/mL of Ziprasidone .The method was found to be applicable for determination of the drug in...
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Posted by admin on Sep 1, 2011 in |
In case of cancer, Traditional Chinese medicine-based herbal medicines have gained increasing acceptance worldwide in recent years and are being pursued by pharmaceutical companies as rich resources for drug discovery. For many years, traditional Chinese medicines (TCM) have been applied for the treatment of cancers in China and beyond. Herbal remedies are clearly a complementary and alternative modality used frequently by patients with hemato-oncological neoplasias during the course of their specific treatment. Cancer is a leading cause of death worldwide. There are a lot of cancer causing agents which are divided as physical carcinogens, chemical carcinogens and biological carcinogens. But most of the carcinogens or causes of cancer are related to our lifestyle like diet, habit, occupation, radiation and some infection, etc. Chemoprevention is highly necessary to prevent cancer related preterm death. In this review, we are studied on the herbal medicines, whenever used in cancer treatment and easily available in market. Cancer is a major cause of death, and globally studies are being conducted to prevent cancer or...
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Posted by admin on Aug 1, 2011 in |
Substituted Quinoxaline have received considerable attention during last two decades as they are endowed with variety of biological activities and have wide range of therapeutic properties. A literature survey indicates that quinoxaline derivatives possess different pharmacological and biological activities, of which the most potent is anti-inflammatory activity. In view of above literature survey, we thought to synthesize a novel substituted quinoxaline...
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Posted by admin on Sep 1, 2010 in |
Objective: To evaluate the antibacterial activity of ethanolic extract of roots of Vetiveria zizanioides. Method: Ethanolic extract of roots of Vetiveria Zizanioides was prepared. Standard cultures of Escherichia coli NCIM 2118; Bacillus subtilis NCIM 2063, P. aeurogenosa NCIM 2036 and Staphylococcus aureus NCIM 2079 were used for the study. The antibacterial tests used were the agar well plate method. Ciprofloxacin was used as the positive control. Results: EEVZ does not show any activity against B.subtilis. However, the activity was less than the standard Ciprofloxacin. The extract shows increasing inhibitory activity with increase in concentration (150-750µg). Conclusions: From our investigation, for screening ethanolic extract of Vetiveria zizanioides the results obtained confirmed therapeutic potency of some plants used in traditional medicine. The plants could be potential source of new antimicrobial...
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Posted by admin on Sep 1, 2010 in |
Thymol is the main volatile compound extracted from dried fruits of Tachyspermum ammi Mill. The compound serves as a biological marker because of its interesting biological activities and is used in traditional medicine, as a bactericide, fungicide, Gastro-intestinal disorders, Bronchitis and asthma, and others. A GC method for the determination of thymol was developed. Chromatographic analysis was carried out on – stainless steel 30m×0.25m×0.25mm packed with polysiloxane column with flow rate 1.0 ml per minute of the carrier gas. Quantification was performed using a FID. The method was validated for specificity, precision, Linearity, accuracy and robustness. The method was found to be precise for different concentrations of thymol. Accuracy was checked by conducting recovery at different level of thymol and the average percentage and recovery was found to be in the range 90%-110%. The Linearity was established over a range of seven different concentrations of the analyte (70%, 80%, 90%, 100%, 110%, 120% and 130% of test concentration) with correlation coefficients of 0.9997 for thymol....
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