Posted by admin on Aug 31, 2023 in |
Epilepsy is a common neurological disorder in clinical practice requiring newer targets for its efficient treatment. Recently, brain renin-angiotensin system has gained immense importance because of its involvement in seizure regulation. Hence, the present study was planned to evaluate whether angiotensin II AT1 receptor antagonists possess anticonvulsant activity in experimental animals. Forty- eight Swiss albino mice were divided into 8 groups: Control – distilled water (5ml/kg), Standard – ethosuximide 200mg/kg, T1- telmisartan 5mg/kg, T2- telmisartan 8mg/kg, V1- valsartan 10mg/kg, V2- valsartan 20mg/kg, E+T2- ethosuximide 200mg/kg+ telmisartan 8mg/kg, E+V2- ethosuximide 200mg/kg+ valsartan 20mg/kg. After 1 hour of administration of control, test and standard drugs intraperitonally, convulsions were induced by administering pentylenetetrazol (60mg/kg- s.c). The time of onset of myoclonic spasm and clonic convulsion were the parameters recorded. The results were analysed by one-way- ANOVA followed by Dunnett’s t test. Telmisartan 8mg/kg, valsartan 10mg/kg, valsartan 20mg/kg significantly increased the latency of onset of myoclonic spasm and clonic convulsion (p< 0.05) as compared to control. The combinations of (ethosuximide + telmisartan 8mg/kg)...
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Posted by admin on Aug 31, 2023 in |
Obesity is related with a number of metabolic difficulties, growing obesity may disrupt hormonal and metabolic systems, which may lead to the body storing extra energy in a variety of forms. The amount of total energy the body has stored as fat is negatively associated with the rate at which leptin circulates in the bloodstream, which is predominantly produced by adipose tissue. It is widely accepted that central serotonin contributes to the inhibition of hunger in mammals and recent reviews have elucidated the mechanisms behind these effects. The hypothalamus regulates hunger as well as energy homeostasis. The digestive tract and adipose tissues are just two examples of peripheral afferent signals that complex brain networks combine to create efferent responses that regulate food intake and energy use. Origin of ghrelin in the circulation is the abdomen and gut. Dopaminergic circuits are used to control intake of food, according to research on human brain imaging. According to the carbohydrate-insulin paradigm, adipose tissue’s endocrine dysregulation rather than acting as a passive fat-accumulator...
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Posted by admin on Aug 31, 2023 in |
Gastric inflammation and ulceration are directly associated with accumulating reactive oxygen species, interleukins, TNF-α, and depletion of antioxidants. In addition to the frequent use of non-steroidal anti-inflammatory drugs, gastric lesions are also provoked by stress, alcohol consumption and Helicobacter pylori. Among other NSAIDs, Indomethacin has been very effective compound to generate a gastric ulcer in rats’ gastric tissues. Ulcer of stomach generated by using Indomethacin involves the production of reactive oxygen species and upregulation of the activity as well as expression of matrix-metalloproteinase (MMPs). Various laboratory studies reveal that compounds from natural origin modify various metabolic disorders by changing pathological and physiological process. It can be a preventive method for various diseases including gastric ulcers. This project aimed to discover the anti-ulcerative effect of methanolic crude leaves extract on gastric ulcers induced by Indomethacin and cold stress in rodent’s model. Crude Neem leaves extract significantly inhibited gastric cancer cells survival in the cell culture model, protection in Indomethacin and stress induced gastric...
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Posted by admin on Aug 31, 2023 in |
Iriflophenone 3-C-β-D glucoside is a Benzophenone derivative which can be obtained from various plant sources like Aquilaria crassna, A. sinensis, A. malaccensis, Cyclopia genistoides, Mangifera indica, Dryopteris ramosa etc. It can act as an important herbal active constituent as it has various pharmacological actions, such as Antidiabetic, anti-inflammatory, antioxidant, and antimicrobial agent. Some scientists demonstrated the antioxidant activity of Iriflophenone 3-C-β-D glucoside and have seen that this compound has no radical scavenging ability against DPPH [2,2-diphenylpicrylhydrazyl] but scavenged ABTS [2,2’-azino-bis(3- ethylbenzothiazoline-6-sulphonic acid)] and peroxyl radicals. So, it can be used as an anti- oxidant agent. From A. sinensis 8 compounds were isolated among which Iriflophenone 3-C- β-D glucoside was present. It is proved that all the isolated compounds have α-glucosidase inhibition activity stronger than acarbose, that is taken as positive drug control. Aqueous fraction of D. ramosa is used for so long by the inhabitants of the Galliyat region of Pakistan to treat their GIT ailments caused by bacteria. Scientists showed that Iriflophenone 3-C-β-D glucoside that is obtained from...
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Posted by admin on Aug 31, 2023 in |
Fatty acids produced by plants protect themselves from pathogens, such as multidrug-resistant bacteria. In the present work, crude extracts, and fatty acid fractions of four pteridophyte species from Assam, Northeast India, were evaluated for their antimicrobial properties, and the bioactive compounds were identified using GC-MS analysis. The crude extract of Pteris semipinnata (Ps), Lygodium microphyllum (Lm), Lycodium flexuosum (Lf), and Lycopodiella cernua (Lc) was found to possess antibacterial and antifungal activities. The lowest MIC and MBC values were 0.25 mg/ml and 0.5 mg/ml for the fatty acid fractions against most of the microbial test strains. The GCMS analysis revealed 21 compounds in Ps, 35 in Lm, 33 in Lc, and 52 in Lf fractions. The present work supports the use of fern species in traditional medicine and...
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